Delving into the Latest Updates on Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

COLYTE-FLAVORED, Colyte, Colyte With Flavor Packs

+ [1]

Target-

Action-

Mechanism-

Therapeutic Areas

Other Diseases

Active Indication

Intestinal preparation

Inactive Indication-

Originator Organization

Braintree Laboratories, Inc.

Active Organization

Braintree Laboratories, Inc.

Inactive Organization

Hospira, Inc.NORVIUM BIOSCIENCE

Drug Highest PhaseApproved

First Approval Date

United States (13 Jul 1984),

Intestinal preparation

Regulation-

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Structure/Sequence

Molecular FormulaClNa

InChIKeyFAPWRFPIFSIZLT-UHFFFAOYSA-M

CAS Registry7647-14-5

View All Structures (5)

The aim of this randomized trial is to compare the proportion of patients achieving an adequate bowel preparation after a 1-day split-dose 4-liter PEG-based bowel preparation regimen (Golytely, Braintree Laboratory Inc, MA, USA) vs. the same regimen given on 2 consecutive days in a population identified as high risk for an inadequate bowel preparation.
2. Research Design: This study is a single-center prospective randomized study at the West Haven VAMC.
3. Methodology:
Primary endpoint: Adequate bowel preparation as defined by a Boston Bowel Preparation Scale (BBPS) score of 2 or 3 (on scale of 0-3) in all 3 colon segments (left, transverse, and right).
Secondary endpoints: Adenoma detection rate, polyp detection rate, sessile serrated polyp/adenoma detection rate, patient tolerability of preparation using the validated Mayo clinic bowel prep tolerability questionnaire, adverse events potentially related to bowel preparation
Patients scheduled for routine outpatient colonoscopy will be eligible if they are at high risk for poor bowel preparation,

Start Date01 Jan 2017

Sponsor / Collaborator-

100 Clinical Results associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate

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100 Translational Medicine associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate

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100 Patents (Medical) associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate

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196

Literatures (Medical) associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate

01 Oct 2024·Journal of Gastrointestinal Surgery

Effect of preoperative oral carbohydrate loading on postoperative insulin resistance, patient-perceived well-being, and surgical outcomes in elective colorectal surgery: a randomized controlled trial

Article

Author: Keerthi, Andi Rajendharan ; Bobby, Zachariah ; Raja, Kalayarasan ; Kumar, Shanmugam Mannoj ; Jha, Ajay Kumar ; Kate, Vikram ; Sureshkumar, Sathasivam ; Anandhi, Amaranathan

BACKGROUNDInsulin resistance (IR) is one of the independent determinants influencing the length of hospital stay (LOH) and postoperative complications in colorectal procedures. Preoperative oral carbohydrate loading (POCL) has emerged as a prospective countermeasure for IR. This study aimed to investigate the effects of preoperative carbohydrate loading on postoperative IR, inflammatory parameters, and clinical outcomes in patients undergoing elective colorectal surgery.METHODSThis was an open-label, parallel arm, superiority randomized controlled trial conducted over 2 years. Participants were assigned to conventional fasting (CF) and oral carbohydrate loading (OCL) groups. Insulin resistance, insulin sensitivity, Glasgow Prognostic Score (GPS), and IL-6 levels were analyzed on the day of surgery, and the first and third postoperative days. Clinical parameters like thirst, hunger, dry mouth, anxiety, weakness, pain, nausea, and vomiting were compared in the perioperative period. Surgical clinical outcomes such as intestinal recovery, time to independent ambulation, postoperative morbidity, and LOH were also studied.RESULTSA total of 72 participants were included, with 36 in each group. In the OCL group, there was a statistically significant decrease in postoperative insulin resistance during preop, POD-1 and POD-3 (p=0.0336). Similarly, inflammatory parameters and the Glassgow prognostic scale were found to be significantly lower in the OCL group (p<0.001). Clinical parameters such as thirst, hunger, and dry mouth were significantly lower in the intervention group (p=0.00) with a shortened LOH.CONCLUSIONThis study demonstrated that preoperative carbohydrate loading is associated with reduced insulin resistance and inflammatory markers, shortened hospital stays, and improved overall clinical outcomes in elective colorectal surgery.

01 Jul 2024·British Journal of Haematology

Cognitive impairment among patients with chronic immune thrombocytopenia

Article

Author: Khan, Umer ; Maruff, Paul ; Daak, Ahmed ; Kuter, David J.

SummaryImmune thrombocytopenia (ITP) is an autoimmune disease typically associated with severely depleted platelet counts. However, additional symptoms (e.g. increased fatigue and memory/concentration difficulties) can profoundly impact patients' quality of life. The nature and severity of cognitive impairment in ITP, and potential association with patient/disease characteristics were evaluated in 49 adults with relapsed/refractory ITP. The Cogstate Brief Battery quantitatively assessed psychomotor function (DET), attention (IDN), visual learning (OCL) and working memory (ONB) individually, as well as DET/IDN and OCL/ONB composites. Clinically important cognitive impairment (defined as z‐score ≤ −1) for ≥2 individual tests was observed in 29 patients (59%). Impairment was highest for IDN (67% of patients), followed by DET (53%), ONB (39%) and OCL (16%). A higher magnitude of impairment was observed for the DET/IDN composite (mean z‐score −1.54; 95% CI, −1.94 to −1.13) than OCL/ONB (mean z‐score −0.21; 95% CI, −0.49 to 0.07). The severity of cognitive impairment was comparable to mild traumatic brain injury and associated with increasing age and fatigue but unrelated to platelet count or corticosteroid use. Overall, these results warrant a clinical need to further consider the potential of cognitive dysfunction in assessing ITP patients.

01 Jun 2024·Cureus

Cardiac Arrest Following GoLytely Consumption: A Potential Trigger for Hypovolemic Shock

Article

Author: Zaher, Eli A ; Patel, Parth ; Adhikari, Bibek ; Ebrahim, Mohamed A

This case report presents a rare but severe complication of polyethylene glycol (PEG) used for colonoscopic bowel preparation. A 71-year-old male developed cardiac arrest secondary to hypovolemic shock following consumption of GoLytely. Despite being hemodynamically stable prior to ingestion, the patient experienced extreme weakness, dizziness, and orthostatic hypotension post-consumption. Evaluation ruled out other causes of arrest. While serious complications from PEG are rare, this case underscores the importance of vigilance. Further investigation is warranted to elucidate the relationship between PEG use and cardiac events and to identify potential risk factors for adverse outcomes associated with bowel preparation regimens.

100 Deals associated with Polyethylene glycol 3350/Potassium chloride/Sodium bicarbonate/Sodium chloride/Sodium sulfate

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R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Intestinal preparation	United States	Braintree Laboratories, Inc.	13 Jul 1984

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Clinical Result

Indication

Phase

Evaluation

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


NCT01283152 (HELP \| PSE, CTgov)	Not Applicable	Hepatic Encephalopathy \| Fibrosis	50	Polyethylene glycol 3350-electrolyte solution (GoLYTELY®) (Polyethylene Glycol 3350-electrolyte Solution (GoLYTELY®))	bdoiwrovbf(syogjezrfm) = wdqjcwjtkm mducllwqex (clbhydqvzn, cazaqrmcqp - fsnbdptrkf) View more	-	11 Dec 2014
				Lactulose (Lactulose)	bdoiwrovbf(syogjezrfm) = rfaffpaijx mducllwqex (clbhydqvzn, pwlmzvdxye - iamldemaif) View more
NCT00953017 (CTgov)	Phase 4	-	425	Amitiza (Lubiprostone) (Miralax Plus Amitiza)	jellxdeotf(utsjfezwpw) = wmmjndmofh wouzbgayzj (qwepsnzyox, twzbpvrgzu - rgozqjpuav) View more	-	30 Nov 2012
				Dulcolax (Bisacodyl) (Miralax Plus Dulcolax)	jellxdeotf(utsjfezwpw) = tvvogupmhe wouzbgayzj (qwepsnzyox, qovpeawnwr - uiehxnzwmr) View more