Drug Type Small molecule drug |
Synonyms 14-O-phosphonooxymethyltriptolide-disodium-salt, MINNELIDE-001 |
Action inhibitors |
Mechanism CIC inhibitors(capicua transcriptional repressor inhibitors), DUX4 inhibitors(Double homeobox protein 4 inhibitors), HSP70 heat-shock proteins inhibitors(HSP70 heat-shock proteins inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Inactive Organization- |
License Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
RegulationOrphan Drug (United States) |
Molecular FormulaC21H27Na2O10P |
InChIKeyYBUXUYKSSJFLBE-KIKMAQITSA-N |
CAS Registry1254702-87-8 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Pancreatic adenocarcinoma metastatic | Phase 2 | United States | 10 Apr 2017 | |
Pancreatic Cancer | Phase 2 | United States | 10 Apr 2017 | |
Stomach Cancer | Phase 2 | - | - | |
Advanced gastric carcinoma | Phase 1 | South Korea | 02 Nov 2020 | |
Refractory acute myeloid leukemia | Phase 1 | - | 01 Apr 2018 | |
Relapsing acute myeloid leukemia | Phase 1 | - | 01 Apr 2018 | |
Advanced cancer | Phase 1 | United States | 10 Oct 2017 | |
Advanced Malignant Solid Neoplasm | Phase 1 | United States | 10 Oct 2017 | |
Breast Cancer | Phase 1 | United States | 10 Oct 2017 | |
Colorectal Cancer | Phase 1 | United States | 10 Oct 2017 |
Phase 2 | Pancreatic Cancer Myc oncogene | 12 | znjermcgsk(nifharyfqw) = tckxgoutms czilpnoolg (azdxanytsv, 2 - 74+) View more | Negative | 28 Apr 2025 | ||
NCT05566834 (ASCO2024) Manual | Phase 1 | Advanced gastric carcinoma Second line | - | bogjvsovaj(hraihipzax) = The most common were neutropenia (19.4%) and abdominal pain (11.1%) gudtgsokka (upfrgbbcym ) View more | Positive | 24 May 2024 | |
Minnelide + Paclitaxel | |||||||
NCT03117920 (AACR2024) Manual | Phase 2 | 17 | vmapsothxi(ueegiakimd) = evidence of activity was observed in 4 patients ttmgpwthez (uiogfjoqpy ) View more | Positive | 09 Apr 2024 | ||
Phase 1 | 45 | frhxdjdprq(wvhuptfmit) = mlysezppya knhgoyxfyj (duutzlfirc ) View more | Positive | 03 Jan 2024 | |||
Phase 1 | 22 | earjujwtfy(hcqmhguoju) = nzglqtvwye xaxxqhgutg (pcbtgsjuuq ) View more | Positive | 24 Jan 2023 | |||
Minnelide+paclitaxel | earjujwtfy(hcqmhguoju) = qrvfquszma xaxxqhgutg (pcbtgsjuuq ) View more |