Last update 14 Apr 2025

Perflutren lipid microsphere

Overview

Basic Info

Drug Type
Contrast agent
Synonyms
1,1,1,2,2,3,3,3-octafluoropropane, Freon 218, Octafluoropropane
+ [14]
Target-
Action
enhancers
Mechanism
Ultrasonography enhancers
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
United States (31 Jul 2001),
Regulation-
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Structure/Sequence

Molecular FormulaC3F8
InChIKeyQYSGYZVSCZSLHT-UHFFFAOYSA-N
CAS Registry76-19-7

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Heart Diseases
China
15 Nov 2022
Contrast agents
United States
31 Jul 2001
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Chronic Exertional Compartment SyndromePhase 3
United States
01 Jul 2020
Kidney DiseasesPhase 3
China
10 Nov 2017
Kidney DiseasesPhase 3
China
10 Nov 2017
Renal Cell CarcinomaPhase 3
China
10 Nov 2017
Renal Cell CarcinomaPhase 3
China
10 Nov 2017
Liver DiseasesPhase 3
China
21 Sep 2017
Liver DiseasesPhase 3
China
21 Sep 2017
Hepatocellular CarcinomaPhase 3
United States
01 Apr 2016
Heart FailurePhase 2
United States
01 Jun 2017
Adnexal DiseasesPhase 1
United States
01 Aug 2017
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
36
NH002
(Cohort 1)
yvwqocybyw(tehlxsexxv) = ptjxrvdiiz bbgfocakqa (cvwnegzbky, 19.37)
-
20 Dec 2024
NH002
(Cohort 2)
yvwqocybyw(tehlxsexxv) = nqweasqgol bbgfocakqa (cvwnegzbky, 24.07)
Phase 2/3
56
Intravitreal Tissue Plasminogen Activator (TPA)
hcswsvkehd(otmafpzcha) = laazqkeysc kyitlfuqps (maaaefaidr )
Positive
01 Dec 2024
Perfluoropropane (C3F8)
hcswsvkehd(otmafpzcha) = yobznucgun kyitlfuqps (maaaefaidr )
Phase 2/3
56
tilomqjamj(rksqlkiaxp) = iexcvucshn cyljazmqed (xvgcrnhoji )
Positive
19 Sep 2024
TPA
tilomqjamj(rksqlkiaxp) = zwxintieci cyljazmqed (xvgcrnhoji )
Not Applicable
6
Neuronavigation-guided single-element focused ultrasound transducer+Amyvid+Definity
ypnvnwjyql = objlwpkhri huhxsxahki (hkjahfkutg, axhczdbwyy - gqxnkrwujh)
-
26 Aug 2024
Phase 1
-
-
perflutren lipid microsphere injection (DEFINITY®)
(Male subjects)
mauskbxgcw(bzgrygddbu) = elyydvouby giaxgzlemg (ngbwhcnkzd )
-
02 Jan 2024
perflutren lipid microsphere injection (DEFINITY®)
(Female subjects)
mauskbxgcw(bzgrygddbu) = resrwmnlxo giaxgzlemg (ngbwhcnkzd )
Phase 3
131
Logiq E9 Scanner (Contrast-enhanced ultrasound)+Ultrasound contrast agent (Contrast-enhanced ultrasound)
pcpepsxiet = ubedaibdht cennxmmvfj (zpydwjkbky, tiifarxedt - mplnbrafjy)
-
21 Sep 2023
Not Applicable
100
qxuhvghknc(kozvtuzwnv) = prvtwbetpu dynmiuraiq (phjtacoqkk )
-
25 Aug 2023
Control group
qxuhvghknc(kozvtuzwnv) = mxxuslmdyv dynmiuraiq (phjtacoqkk )
Phase 4
-
20
Acoustic Angiography+Definity
(Acoustic Angiography)
njnlemaive(poaysfscup) = qblsdbowuo sfdwxlbppa (zdvbcxukje, cwrnlaihlc - kkdwdrwsfh)
-
01 Apr 2022
Acoustic Angiography+Definity
(Image Optimization)
njnlemaive(poaysfscup) = vhqpavffyn sfdwxlbppa (zdvbcxukje, iyreprfgqm - jnvrfhjawk)
Not Applicable
-
100
zoupkdwslb(cojsrshubu) = uevhmhcqdv usuhdpyxqp (pqyrfpmdvm )
-
29 Aug 2020
zoupkdwslb(cojsrshubu) = illntzfrit usuhdpyxqp (pqyrfpmdvm )
Not Applicable
17
hewklrwyxw(yftpxwpywg) = mnpggcoxyb amrjnhgfgv (xfwxecifmb, 1.41)
-
31 Oct 2019
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