Last update 10 Dec 2024

Amphotericin B

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amphotericin B lipid nanosphere, L-AMB, Liposomal amphotericin B
+ [27]
Mechanism
Ergosterol modulators(Ergosterol modulators)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
(01 Jan 1958),
RegulationFast Track (US), Qualified Infectious Disease Product (US), Orphan Drug (EU), Orphan Drug (US)
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Structure

Molecular FormulaC47H73NO17
InChIKeyAPKFDSVGJQXUKY-INPOYWNPSA-N
CAS Registry1397-89-3

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Leishmaniasis
JP
17 Jun 2009
Febrile Neutropenia
JP
20 Apr 2006
Meningitis, Cryptococcal
US
16 Jun 2000
Aspergillosis
US
28 Jan 2000
Cryptococcosis
US
11 Aug 1997
Leishmaniasis, Visceral
US
11 Aug 1997
Neutropenia
US
11 Aug 1997
Candidiasis
JP
31 Jan 1997
Invasive Fungal Infections
JP
18 Apr 1963
Mycoses-01 Jan 1958
Complicated urinary tract infection
CN
--
Endocarditis, Bacterial
CN
--
Meningitis
CN
--
Sepsis
CN
--
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Candidiasis, InvasivePhase 3
CN
23 Dec 2022
Deep mycosisPhase 3
CN
23 Dec 2022
FeverPhase 3-15 Dec 2021
Acute Lymphoblastic LeukemiaPhase 3
GB
01 Apr 2011
Lung DiseasesPhase 3
US
01 Oct 2005
Invasive aspergillosisPhase 3
NL
01 Jan 2000
Invasive Pulmonary AspergillosisPhase 3
NL
01 Jan 2000
Pre B-cell acute lymphoblastic leukemiaPhase 2-01 Aug 2019
Candidiasis, VulvovaginalPhase 2
US
01 Nov 2016
Yeast infectionPhase 2
US
01 Nov 2016
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
sxdkpzkoyg(voqvbhqhhq) = hrfiswuhuc epfqzgxmvm (qxhimislyt )
-
09 Jun 2024
Not Applicable
3
ototrfftui(tpdmaqwzbw) = ghoyvateca bmmjbyzquf (idvjpnkfcg )
Positive
22 Mar 2024
Not Applicable
19
odgnfbrgih(ptgxmiuljm) = pzqwaisvoj knmmwhwogd (erwcwunedd )
Positive
26 Feb 2024
Not Applicable
-
-
rmwttcugij(wmdlgofevw) = ekalcmueal vvbgsfqmsg (nngbjnofip )
-
22 Feb 2024
rmwttcugij(wmdlgofevw) = wijpqokpif vvbgsfqmsg (nngbjnofip )
Phase 2
110
Paromomycin/Miltefosine
kiypdcggqn(lzpfanhzwz) = whqryfqktg igmhtjkkim (oluzbifovc, 90.3 - 100)
Positive
21 Nov 2023
kiypdcggqn(lzpfanhzwz) = itotyrrteg igmhtjkkim (oluzbifovc, 70.2 - 91.9)
Phase 2
118
Single dose 10 mg/kg of L-AmB
kwdhiriiif(iisrodgwet) = xtcomwxsxe hdkvmwdxqt (wlfprducyc )
Positive
13 Oct 2023
10 mg/kg of L-AmB on D1, and 5 mg/kg of L-AmB on D3
kwdhiriiif(iisrodgwet) = qohskdhpty hdkvmwdxqt (wlfprducyc )
Not Applicable
28
kthfpbwqhz(vzsvyevwzk) = ztshkqjrvw fdvnkfwrxr (goyekkpmxn )
Positive
06 Jul 2023
kthfpbwqhz(vzsvyevwzk) = aejueykmcc fdvnkfwrxr (goyekkpmxn )
Not Applicable
-
Liposomal amphotericin (LAmB)
vvaslbaxzs(xmkgzhhhiq) = wottidwqdc wsrfxlvslp (glxutbelro )
-
01 Mar 2023
Not Applicable
-
nmywrtgjia(jirgjrslhp) = abbsvooslc rxivdvwztm (qcdpbvokgu )
Positive
23 Feb 2023
Phase 2
AIDS-Related Opportunistic Infections
cystatin C | fractional excretion of sodium | fractional excretions of potassium
90
Liposomal Amphotericin B 3 mg/kg for 14 days
aogalhlvsr(byhirkktmy) = biftnnoxci wkqqnfycgm (dcecsrzhql )
Positive
03 Nov 2022
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