Last update 12 Nov 2024

Exarafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BRAF kinase inhibitor - Kinnate Biopharma, KIN 2787, KIN-002787
+ [1]
Target
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationOrphan Drug (US), Fast Track (US)
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Structure

Molecular FormulaC26H34F3N5O3
InChIKeyGZMYLSJUNSCMTD-MOPGFXCFSA-N
CAS Registry2639957-39-2

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BRAF V600K Mutation-Positive Solid TumorsPhase 1
US
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
CN
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
AU
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
FR
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
NL
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
KR
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
ES
04 Aug 2021
BRAF V600K Mutation-Positive Solid TumorsPhase 1
TW
04 Aug 2021
MelanomaPhase 1
US
04 Aug 2021
MelanomaPhase 1
CN
04 Aug 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
52
zrhgrssmym(yhbxrqkulq) = blurred vision (n=1), CPK increased (n=1), GI bleed, nausea, neuralgia, & renal injury (n=1) jyiqxcntep (ablnrncfoc )
Positive
14 Sep 2024
Phase 1
NRAS Mutant Melanoma | BRAF mutation Solid Tumors
BRAF Altered | NRAS Mutation
52
unbkwmpyku(uwoorvyfnt) = Dose limiting toxicities observed at the highest dose level were Grade 3 (Gr3) acneiform rash & Gr3 macular rash auvolzafqc (ribycnjkbd )
Positive
14 Apr 2023
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Approval

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Regulation

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