Last update 24 Feb 2024

Exarafenib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BRAF kinase inhibitor - Kinnate Biopharma, KIN 2787, KIN-002787
+ [1]
Target
Mechanism
BRAF inhibitors(Serine/threonine-protein kinase B-raf inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
RegulationFast Track (US), Orphan Drug (US)

Structure

Molecular FormulaC26H34F3N5O3
InChIKeyGZMYLSJUNSCMTD-MOPGFXCFSA-N
CAS Registry2639957-39-2

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
BRAF V600K Mutation-Positive Solid TumorsPhase 1FR
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Solid tumorPhase 1DK
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Non-Small Cell Lung CancerPhase 1TW
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MelanomaPhase 1TW
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NeuroblastomaPhase 1TW
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Clinical Trial Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
NRAS Mutant Melanoma | BRAF mutation Solid Tumors
BRAF Altered | NRAS Mutation
52
ittlyrlpyx(lodsqzndon) = Dose limiting toxicities observed at the highest dose level were Grade 3 (Gr3) acneiform rash & Gr3 macular rash znivrnfzyo (iglkazyhwd )
Positive
14 Apr 2023
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Regulation

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