Delving into the Latest Updates on Hydroquinidine Hydrochloride with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Idrochinidine, Serecor

Target

Sodium channels

Action

blockers

Mechanism

Sodium channels blockers

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Arrhythmias, Cardiac

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

RegulationOrphan Drug (European Union)

Login to view timeline

Structure/Sequence

Molecular FormulaC20H27ClN2O2

InChIKeyMULXTQKDWYBJMO-VJAUXQICSA-N

CAS Registry1476-98-8

View All Structures (2)

Sargassum polycystum (S. polycystum) is a brown macroalga with a high phytochemical content, making it a nutritious and bioactive food source. However, information on factors contributing to health benefits, like antioxidants and cytotoxicity, is less explored for Malaysian S. polycystum. In this study, three extracts of S. polycystum were characterized using a combination of analytical techniques. Despite similar carbohydrate content across all extracts, water extract exhibited the highest protein [21.90 ± 1.01 albumin equivalent (μg/mg)] and phenolic [7.73 ± 1.95 gallic acid equivalent (μg/mg)] contents. However, it displayed the lowest antioxidant and anticancer activities [half-maximal inhibitory concentration (IC₅₀) of > 2000 μg/mL]. Interestingly, ethanolic extract demonstrated the strongest scavenging activity (IC₅₀ of 397.90 ± 20.43 μg/mL) and selective anticancer activity against MCF7 breast cancer cells (IC₅₀ of 338.63 ± 48.98 μg/mL). Untargeted metabolomic profiling confirmed the differences in the chemical composition of the extracts. Subsequently, correlation and docking analyses were used to identify the potential bioactive compounds within the extracts. The ethanolic extract is a rich source of these bioactive compounds with superior antioxidant and anticancer properties, highlighting the need for further research on its potential utility in the food industry.

01 Mar 2025·Journal of Food Composition and Analysis

The effects of chilling (4 °C) and non-chilling (12 °C) temperatures on storage quality and flavor development of yellow peach fruit

Author: Zheng, Xiaolin ; Ye, Zhengwen ; Zhang, Shiying ; Wang, Lufan ; Shen, Shuling ; Zhou, Huijuan ; Huan, Chen

This study investigated the effects of storage temperatures (4 °C and 12 °C) on fruit quality and flavor development in ′Jinxiu′ yellow peach through anal. of physiol. parameters, textural properties, sugar and acid content, as well as flavor characteristic.The results indicated that storing peaches at 12 °C, a non-chilling temperature, maintained normal fruit ripening and flavor development while preventing chilling injury (CI) symptoms.In contrast, although storing at 4 °C effectively delayed fruit softening, it potentially induced CI and abnormal flavor changes, notably an increase in bitterness during the late storage period and the following shelf life.Electronic tongue anal. revealed that fruit stored at 12 °C exhibited a higher sourness and umami taste, while those stored at 4 °C maintained higher sweetness but increased bitterness.Further metabolite anal. revealed that the accumulation of certain bitterness-related compounds (such as 3,5,6,7,8,3′,4′-heptamethoxyflavone, coumaroyl quinic acid, gardenoside, sweroside, and octopine) under 4 °C storage conditions might be the primary cause of increased fruit bitterness.This research provides insights into the potential interaction between storage temperature and key fruit quality parameters.The findings offer guidance for postharvest management strategies aimed at maintaining optimal fruit quality and consumer acceptance.

01 Feb 2025·Trends in Cardiovascular Medicine

Letter to the Editor: Is oral hydroquinidine a real alternative to intravenous quinidine for intubated patients in intensive care unit?

Letter

Author: Cumin, Marianne ; Feka, Alma ; Sadeghipour, Farshid

100 Deals associated with Hydroquinidine Hydrochloride

Login to view more data

External Link

KEGG	Wiki	ATC	Drug Bank
D08049	Hydroquinidine Hydrochloride	C01BA	DB15300

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Arrhythmias, Cardiac	-	-	-

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ESC2020	Not Applicable	Brugada Syndrome	98	Hydroquinidine	xqialfkoje(axtupfphsp) = mzsywhgahe psserpasli (vvfkpvensy ) View more	-	29 Aug 2020
QUIDAM study (ESC2016)	Not Applicable	Arrhythmias, Cardiac \| Brugada Syndrome	-	Hydroquinidine	(kletasohkb) = epjinayyof smegxxmxww (zpedzyadub ) View more	-	27 Aug 2016
QUIDAM study (ESC2016)	Not Applicable	Arrhythmias, Cardiac \| Brugada Syndrome	-	Placebo	(kletasohkb) = jjtgyssiiv smegxxmxww (zpedzyadub ) View more	-	27 Aug 2016