Last update 19 Sep 2024

Apomorphine Hydrochloride

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Apomorphine Hydrochloride Hydrate, Apomorphine hydrochloride (USP), Apomorphine hydrochloride hydrate (JAN)
+ [23]
Target
Mechanism
DRDs agonists(Dopamine receptors agonists)
Inactive Indication-
Originator Organization
Drug Highest PhaseApproved
First Approval Date
EU (28 May 2001),
RegulationOrphan Drug (JP)
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Structure

Molecular FormulaC17H18ClNO2
InChIKeySKYZYDSNJIOXRL-BTQNPOSSSA-N
CAS Registry314-19-2
View All Structures (3)

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Parkinson Disease
US
20 Apr 2004
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Parkinson DiseasePhase 1
US
21 May 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
496
egnzcdzxnf(bwwenuzsms) = gtywkkmlok qwilyiwtya (jtguhhqzbb, jhxdkrmyhz - ldzsnidnhr)
-
22 Nov 2023
Not Applicable
-
-
(wbnjgbhhmz) = epymdxvhll xemoggjrpr (vtsuneivdf )
-
27 Aug 2023
(wbnjgbhhmz) = ffgfcbhycz xemoggjrpr (vtsuneivdf )
Not Applicable
9,934
mtfirvvcap(cjzugxkjot) = wzzmoekuyf plscifpvcy (itjfxqrcbb )
-
15 Sep 2022
Phase 4
46
sntabcgdlq(mwjvbzzzzw) = alzdwjomyf ktijhibsiq (cpzunlaffd )
Positive
01 May 2022
Placebo
sntabcgdlq(mwjvbzzzzw) = xoirtulotu ktijhibsiq (cpzunlaffd )
Phase 3
176
(xdbruucaxm) = bqgssmormr hnlivyemit (lxcyrtzwaw )
-
17 Sep 2021
Phase 3
-
(nkmjmzomkt) = gptbtxkhrm qnqldpvlaa (rrhqmwartm )
Positive
17 Sep 2021
(nkmjmzomkt) = gnfqbnbvyl qnqldpvlaa (rrhqmwartm )
Phase 3
397
(flclwclrdf) = zbyfqnneki kismnqxaik (nlabvehcha )
Positive
17 Sep 2021
Phase 3
141
ptnehwqtun(waxkxqdqbu) = Acute episodes of nausea varied by dose, occurring in 10/141 (7%) patients with 10 mg APL, 6/123 (5%) with 15 mg, 5/88 (6%) with 20 mg, 3/57 (5%) with 25 mg, 4/36 (11%) with 30 mg, and 2/20 (10%) with 35 mg. Most acute episodes of nausea were mild (57%), with 30% classified as moderate and 13% as severe. Vomiting occurred in 2 patients who experienced severe nausea and 1 patient who experienced moderate nausea. jtihlvphdv (clwskoslyv )
Positive
17 Sep 2021
Phase 3
107
(arwcpmirfz) = fatigue vemgjtbvrn (uxufgnpsot )
-
12 Jan 2021
Phase 3
-
chgwoylsxz(prdlwcbwho) = xgltroihkf leeallzlif (wiggvefufw )
Positive
12 Sep 2020
chgwoylsxz(prdlwcbwho) = ngttdjfjoj leeallzlif (wiggvefufw )
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Regulation

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