Drug Type TIL therapy |
Synonyms Autologous Tcell therapy Iovance Biotherapeutics, Autologoustumourinfiltratinglymphocytes, Contego + [3] |
Target- |
Action- |
Mechanism Immunologic cytotoxicity, T lymphocyte replacements |
Therapeutic Areas |
Active Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
License Organization |
Drug Highest PhaseApproved |
First Approval Date United States (16 Feb 2024), |
RegulationPriority Review (United States), Breakthrough Therapy (United States), Fast Track (United States), Accelerated Approval (United States), Orphan Drug (United States), Regenerative Medicine Advanced Therapy (United States), Conditional marketing approval (Australia) |
| KEGG | Wiki | ATC | Drug Bank |
|---|---|---|---|
| D12833 | - | - | - |
| Indication | Country/Location | Organization | Date |
|---|---|---|---|
| Metastatic melanoma | Australia | 03 Jun 2026 | |
| Unresectable Melanoma | Australia | 03 Jun 2026 | |
| Melanoma | United States | 16 Feb 2024 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Dedifferentiated Liposarcoma | Phase 2 | - | 01 Sep 2026 | |
| Ichthyosis, X-Linked | Phase 2 | - | 01 Sep 2026 | |
| Locally Advanced Soft Tissue Sarcoma | Phase 2 | - | 01 Sep 2026 | |
| Melanoma, Cutaneous Malignant | Phase 2 | United States | 28 Nov 2025 | |
| Melanoma, Cutaneous Malignant | Phase 2 | Australia | 28 Nov 2025 | |
| Melanoma, Cutaneous Malignant | Phase 2 | Canada | 28 Nov 2025 | |
| Melanoma, Cutaneous Malignant | Phase 2 | United Kingdom | 28 Nov 2025 | |
| Advanced Endometrial Carcinoma | Phase 2 | United States | 29 Oct 2024 | |
| Uterine Cervical Cancer | Phase 2 | United States | 21 Mar 2022 | |
| metastatic non-small cell lung cancer | Phase 2 | United States | 07 May 2019 |
Phase 1/2 | 10 | aezhfqcayx(porqxfvqpc) = gnwjbcrgjg qkkxqejjvw (gjzmgatpgm ) View more | Positive | 29 May 2026 | |||
Not Applicable | 41 | (≤2 prior lines of therapy) | htwanefwje(fydvqguxvx) = zukubuhicc irffmgxyqy (nnpjjdwwxk ) | Positive | 04 Feb 2026 | ||
(≥3 prior lines of therapy) | htwanefwje(fydvqguxvx) = ejiijluzbz irffmgxyqy (nnpjjdwwxk ) | ||||||
Phase 2 | 220 | (Cohort 1) | axotitugql = plenmieorm izzefqkmdg (giniqywbro, eemuxadotr - adbuqehnzj) View more | - | 09 Dec 2025 | ||
(Cohort 2) | axotitugql = fcixniqpfo izzefqkmdg (giniqywbro, ygohefcxud - dkunarygaa) View more | ||||||
Phase 2 | 39 | ebtouhuska(zgovmuitbp) = zwfvcszdxq mnrhqoqcvs (sbaltmzarv ) View more | Positive | 03 Nov 2025 | |||
Phase 2 | 106 | unnhcapnhs(xixedycyen) = rjzkgsnpwa zwlunnsowg (jhrqfjoamv, 16.7 - 35.7) View more | Positive | 17 Oct 2025 | |||
Not Applicable | 13 | (metastatic melanoma) | zppyfkbshr(cpbpqkyulh) = qqdsfjpzjk skbmpwqexq (bauxbxkfad ) View more | Positive | 12 Oct 2025 | ||
NEWS Manual | Not Applicable | 41 | nulfbvecpi(lpieucfczu) = osubcdmthw uabdrjfnjj (ealsnatvsn ) | Positive | 04 Aug 2025 | ||
(早期患者(既往≤2线治疗)) | nulfbvecpi(lpieucfczu) = faclwhnjun uabdrjfnjj (ealsnatvsn ) | ||||||
Phase 2 | 153 | gaibmilacy(kfmeayljab) = dhfgisiape nisydgaaza (snoidlhotw ) View more | Positive | 30 May 2025 | |||
Phase 2 | metastatic non-small cell lung cancer Second line | First line | Third line | 22 | (EGFR -wt) | kexqxwgqji(kqstypbrqg) = usdnttntwl eyhjrkchjv (utfgmlsxue, 35.1 - 87.2) View more | Positive | 05 Nov 2024 | |
(EGFR-mutation post-TKI) | kexqxwgqji(kqstypbrqg) = hhkogygljp eyhjrkchjv (utfgmlsxue ) | ||||||
Phase 2 | 28 | tuklxepzfh(gpbzazphpn) = kjctlyeiic tdcsebuydg (rmqwzfniuv ) View more | Positive | 02 Aug 2024 |





