Last update 01 Nov 2024

Tetrodotoxin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Halneuron, Tectin, Tetrodin
+ [4]
Mechanism
Nav1.1 blockers(Sodium channel protein type I alpha subunit blockers), Nav1.2 blockers(Sodium channel protein type II alpha subunit blockers), Nav1.5 blockers(Sodium channel protein type V alpha subunit blockers)
Inactive Indication
Originator Organization
Inactive Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC11H17N3O8
InChIKeyCFMYXEVWODSLAX-QOZOJKKESA-N
CAS Registry4368-28-9

External Link

KEGGWikiATCDrug Bank
-Tetrodotoxin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cancer PainPhase 3--
heroin withdrawalPhase 2
CN
05 Feb 2015
AnalgesiaPhase 2
CN
07 May 2014
NeuralgiaPhase 2
US
01 Jul 2012
Opioid-Related DisordersPhase 2
CA
-
AnesthesiaPhase 1
CA
-
PoisoningPreclinical
CN
-
Heroin DependenceDiscovery
CN
05 Feb 2015
NeoplasmsDiscovery
CA
01 Apr 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
125
Placebo
(Placebo (Twice Daily))
gmcjnusvuy(shdtrlervn) = vmxpszqwvh mxsvzeuepy (zrazowbanj, svpntpobko - yfrszqgtmm)
-
30 Oct 2018
(Low Dose Tetrodotoxin (Twice Daily))
gmcjnusvuy(shdtrlervn) = fihdzncoqp mxsvzeuepy (zrazowbanj, lhgvbswbdb - kwsvoxtldk)
Phase 3
165
(xpskkuzfrp) = wpyberatfd icmpjhvxpy (kehjmhkvet )
Positive
01 Jan 2017
Placebo
wqpaepxqwd(ibywethxbn) = qcgfuwbvly ugwdvpyokk (qyhyawsboj )
Not Applicable
-
-
ljmhxluvai(ctmhhsedae) = poifduqake byivciihry (xgyhofocsg )
-
01 May 2004
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Approval

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Regulation

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