Last update 21 Nov 2024

TLC-388 HCl

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lipotecan
+ [1]
Mechanism
HIF-1α inhibitors(Hypoxia-inducible factor 1 alpha inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC39H30N8O15
InChIKeyJCCCLGDYMMTBPM-HXDHBHDHSA-N
CAS Registry1432468-79-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Renal Cell CarcinomaPhase 2
TW
30 Nov 2012
Neuroendocrine TumorsPhase 2--
Rectal CancerPreclinical
TW
26 Dec 2015
Liver CancerPreclinical
CN
12 Nov 2014
Liver CancerPreclinical
CN
12 Nov 2014
Liver CancerPreclinical
CN
12 Nov 2014
Advanced Hepatocellular CarcinomaPreclinical
CN
10 Apr 2014
Advanced Hepatocellular CarcinomaPreclinical
TW
10 Apr 2014
Metastatic Renal Cell CarcinomaPreclinical
TW
30 Nov 2012
Locally Advanced Hepatocellular CarcinomaPreclinical
TW
27 Oct 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
23
(hngurwiifi) = utrdbmjrpj qkbjqlzsgy (ztiwcyxrjp, 0.4 - 15)
Negative
01 May 2020
Phase 2
23
(orshsxjoft) = The most common treatment-related hematologic adverse events at grade 3 or higher were leukopenia (22.7%), anemia (31.8%), and thrombocytopenia (18.2%), respectively. sjlnqwbclk (ekriyflday )
Negative
26 May 2019
Not Applicable
-
(yrulefdgxd) = slloydavlc idnqyzyqak (ppvrkuuqia, 1/5 MTD)
-
15 May 2015
Phase 1
-
(grqsxdpsvt) = thrombocytopenia and febrile neutropenia kandhnjbyg (bwafkqttuz )
-
20 May 2011
Phase 1
-
(dlqphfxhkm) = iglzsrdopx wgldmjdvxn (jnmazzevgf )
-
20 May 2010
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Approval

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Regulation

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