Last update 05 Nov 2024

TLC-388 HCl

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Lipotecan, TLC 388, TLC-388
+ [1]
Mechanism
HIF-1α inhibitors(Hypoxia-inducible factor 1 alpha inhibitors), TOP1 inhibitors(DNA topoisomerase I inhibitors)
Therapeutic Areas
Active Indication
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
RegulationSpecial Review Project (CN)
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Structure

Molecular FormulaC39H30N8O15
InChIKeyJCCCLGDYMMTBPM-HXDHBHDHSA-N
CAS Registry1432468-79-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Portal Vein ThrombosisPhase 2
TW
14 Apr 2017
Venous ThrombosisPhase 2
CN
-14 Apr 2017
Rectal CancerPhase 2
TW
26 Dec 2015
Neuroendocrine TumorsPhase 2
TW
10 Jun 2015
Liver CancerPhase 2
CN
12 Nov 2014
Liver CancerPhase 2
CN
12 Nov 2014
Liver CancerPhase 2
CN
12 Nov 2014
Advanced Hepatocellular CarcinomaPhase 2
CN
10 Apr 2014
Advanced Hepatocellular CarcinomaPhase 2
TW
10 Apr 2014
Advanced Renal Cell CarcinomaPhase 2
TW
30 Nov 2012
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
23
dzxfmwcwlg(bgzuitxhkh) = ioykvssrpe itmxjoiucg (vptzaeivbn, 0.4 - 15)
Negative
01 May 2020
Phase 2
23
(xctaahwkuz) = The most common treatment-related hematologic adverse events at grade 3 or higher were leukopenia (22.7%), anemia (31.8%), and thrombocytopenia (18.2%), respectively. osptyborrr (puvdwuyqcw )
Negative
26 May 2019
Phase 1
-
bvmchkisxp(twxjxuredb) = thrombocytopenia and febrile neutropenia dfbpvwtrnd (jdzshexlrh )
-
20 May 2011
Phase 1
-
txwqygartp(fnotbpdxdn) = kgcqtoutbl erlsvznguw (wxkdbulguh )
-
20 May 2010
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Approval

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Regulation

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