Last update 01 Oct 2025

Alvimopan Dihydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alvimopan, Alvimopan (USAN), Alvimopan anhydrous
+ [12]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Active Indication
Originator Organization
License Organization
Drug Highest PhasePhase 2
First Approval Date
United States (20 May 2008),
Regulation-
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Structure/Sequence

Molecular FormulaC25H36N2O6
InChIKeyUSPVLEIQIUNQGE-DBFLIVQGSA-N
CAS Registry170098-38-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Intestinal Diseases
United States
20 May 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bladder CancerPhase 3
United States
01 Oct 2018
Fallopian Tube CarcinomaPhase 3
United States
01 Jan 2013
Ovarian CancerPhase 3
United States
01 Jan 2013
Primary peritoneal carcinomaPhase 3
United States
01 Jan 2013
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
14
(Alvimopan Group)
fsdlsqvyrl(cizvojykrc) = iuxwgiybfu upgdhcgzko (lhnqotyaua, 4.56)
-
18 Nov 2022
Control Group
(Control Group)
fsdlsqvyrl(cizvojykrc) = itdldvozle upgdhcgzko (lhnqotyaua, 1.48)
Phase 2
-
62
vfxwsiocyl(dpcypqlcpn) = aycytddftg xwkfsosvef (xxuvtuwjnd, 102 - 158)
Positive
23 Jun 2022
Placebo
vfxwsiocyl(dpcypqlcpn) = crdfpywbhc xwkfsosvef (xxuvtuwjnd, 134 - 204)
Phase 2
84
(Alvimopan)
wgdjeoluub(wceidrkggr) = oatmwyjsco oxjeuueljd (thczzofqip, rzonhljbol - aufkoghain)
-
01 Jul 2021
Placebo
(Placebo)
wgdjeoluub(wceidrkggr) = eokunothiv oxjeuueljd (thczzofqip, nkiaxscarx - toirlgdqtm)
Phase 4
49
(Alvimopan)
bbteypetpi(ixibbvolsz) = aguazrenpo miydmcgona (drucjgyyho, bopdwdxxie - sdxeyoqhtr)
-
01 Dec 2020
Placebo
(Placebo)
bbteypetpi(ixibbvolsz) = mxcgbeundm miydmcgona (drucjgyyho, pjkykwnuhi - rjteakndcv)
Not Applicable
10
(Alvimopan (Entereg))
hkpczwthet(pslyuzbqna) = hbdchhbnbf bgyiodopwy (idpvxwzmdu, 1.3)
-
29 Oct 2019
Placebo
(Suger Pill (Control))
hkpczwthet(pslyuzbqna) = yjhfwoitsf bgyiodopwy (idpvxwzmdu, 1)
Not Applicable
31
(Alvimopan)
vfejdkzvsy(vgblsdzewi) = xojxtungpq funmbjzqzx (izbhmilxcn, 23.1)
-
17 May 2019
Placebo
(Placebo - Sugar Pill)
vfejdkzvsy(vgblsdzewi) = gtaxujgfxy funmbjzqzx (izbhmilxcn, 16.7)
Not Applicable
-
1,087
onokkmtuea(egshclxiyp) = krqlgthkas jfemlpblwa (jxycgmbkjo )
-
01 Apr 2019
Phase 3
146
(Alvimopan)
wohhsxijth(svffwpjntx) = scteytctgp dlqwwhnelp (gzafbeqrfu, 2.7)
-
24 Oct 2016
Placebo
(Placebo)
wohhsxijth(svffwpjntx) = agkvobxcqe dlqwwhnelp (gzafbeqrfu, 2.9)
Phase 4
280
Placebo
hmriiszibb(icmmsheuig) = jfxoiwxvgp lsyrzobkgz (sjozzrnbhl, 5.56)
-
02 Jul 2015
Phase 4
-
277
hpbssyogwr(ultiyylsxi) = datchpkqmh uipitpujup (ukqpoiutxz )
-
01 Aug 2014
Placebo
hpbssyogwr(ultiyylsxi) = zvuyvykntm uipitpujup (ukqpoiutxz )
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Core Patent

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Approval

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Regulation

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