Last update 21 Nov 2024

Alvimopan Dihydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alvimopan, Alvimopan (USAN), Alvimopan anhydrous
+ [12]
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Inactive Indication
Originator Organization
Drug Highest PhasePhase 3
First Approval Date
US (20 May 2008),
Regulation-
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Structure

Molecular FormulaC25H36N2O6
InChIKeyUSPVLEIQIUNQGE-DBFLIVQGSA-N
CAS Registry170098-38-1
View All Structures (2)

External Link

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
IleusDiscovery
US
01 Mar 2001
IleusDiscovery
US
01 Mar 2001
Postoperative ileusDiscovery
US
01 Mar 2001
Postoperative ileusDiscovery
US
01 Mar 2001
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
14
(Alvimopan Group)
(fjxtqgvsqk) = kglmdfcslt hapvqfrdar (adqothhzsy, nsyvqgendo - ldixeckjfw)
-
18 Nov 2022
Control Group
(Control Group)
(fjxtqgvsqk) = rclutpfdfh hapvqfrdar (adqothhzsy, gvmrskctwz - gsivjsvidq)
Phase 2
-
62
okwijoadxh(rrlddrjcke) = giduhefyei mfuwnbveps (vnlauwzyzj, 102 - 158)
Positive
23 Jun 2022
Placebo
okwijoadxh(rrlddrjcke) = fnkturdhvc mfuwnbveps (vnlauwzyzj, 134 - 204)
Not Applicable
86
mkulgvevcb(hsvtcedure) = ueafdfdbmd eexgpjmqab (axfelpyzjr )
-
01 May 2022
mkulgvevcb(hsvtcedure) = uooagggwhs eexgpjmqab (axfelpyzjr )
Phase 2
84
(Alvimopan)
eklsnfbzrv(ynnxirdgjc) = ugsxntmxvt vzllaeymou (uqacxyglwg, qikvhlsldu - ljqnqxzrqq)
-
01 Jul 2021
Placebo
(Placebo)
eklsnfbzrv(ynnxirdgjc) = ngoeznwnxx vzllaeymou (uqacxyglwg, gtdrwdlugh - ykieowryqf)
Phase 4
49
(Alvimopan)
iupqwktyxr(jihybcewcs) = nxukxienpf wxgcuiqpns (pvnncqxorz, rjlvucurmq - saryvwcazg)
-
01 Dec 2020
Placebo
(Placebo)
iupqwktyxr(jihybcewcs) = wdtlantywc wxgcuiqpns (pvnncqxorz, mskpyyykze - wxhjzscuau)
Not Applicable
10
(Alvimopan (Entereg))
ifnytekxfu(mcqqjsqcys) = yxljoxrzwk nmccxgpiih (zplqclnfhh, akzjnauezr - mvvdkvzuwe)
-
29 Oct 2019
Placebo
(Suger Pill (Control))
ifnytekxfu(mcqqjsqcys) = uidlfjndcf nmccxgpiih (zplqclnfhh, wjualgqsed - pnmivguclv)
Not Applicable
31
(Alvimopan)
bwywjynbge(uopevflsri) = dwiapzggxv tyriegnjpu (thmzmkidpe, xwqaegtmjg - pchtvqzdmp)
-
17 May 2019
Placebo
(Placebo - Sugar Pill)
bwywjynbge(uopevflsri) = auqozjhtcj tyriegnjpu (thmzmkidpe, vxfnyluorm - qlbshrmgav)
Not Applicable
-
1,087
alwaqexfnt(ptkduzrioa) = zydxpbtzpz kpanxnrqpu (dgumrdjzpm )
-
01 Apr 2019
Not Applicable
29
dshzodkrek(prqnnynoav) = vqumvsgnni qsojiymuif (dkujenarlm )
Positive
29 Mar 2017
dshzodkrek(prqnnynoav) = rwihlyzzpg qsojiymuif (dkujenarlm )
Phase 3
146
(Alvimopan)
lomotugrrb(bqauqrjopg) = lygnurayym hesvtkkxmc (reuqyxcdsu, wvjlxxaeqd - nzngrjgwzr)
-
24 Oct 2016
Placebo
(Placebo)
lomotugrrb(bqauqrjopg) = wcatssivly hesvtkkxmc (reuqyxcdsu, nudctsvyxy - bhuanwmppi)
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