Last update 19 Jul 2025

Alvimopan Dihydrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Alvimopan, Alvimopan (USAN), Alvimopan anhydrous
+ [12]
Action
antagonists
Mechanism
μ opioid receptor antagonists(Mu opioid receptor antagonists)
Originator Organization
License Organization
Drug Highest PhasePhase 3
First Approval Date
United States (20 May 2008),
Regulation-
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Structure/Sequence

Molecular FormulaC25H36N2O6
InChIKeyUSPVLEIQIUNQGE-DBFLIVQGSA-N
CAS Registry170098-38-1

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Intestinal Diseases
United States
20 May 2008
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Bladder CancerPhase 3
United States
01 Oct 2018
Fallopian Tube CarcinomaPhase 3
United States
01 Jan 2013
Ovarian CancerPhase 3
United States
01 Jan 2013
Primary peritoneal carcinomaPhase 3
United States
01 Jan 2013
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
United States
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Australia
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
ConstipationPhase 3
Austria
01 Aug 2005
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
14
(Alvimopan Group)
ffguqmbkki(btqfpibskw) = sdwtndghgj bioswklshh (fcnfctvygz, 4.56)
-
18 Nov 2022
Control Group
(Control Group)
ffguqmbkki(btqfpibskw) = pwystimtxh bioswklshh (fcnfctvygz, 1.48)
Phase 2
-
62
oborugdvsa(umrjklxboy) = dfhffnjtdq tgexuvofpb (bjxilirueh, 102 - 158)
Positive
23 Jun 2022
Placebo
oborugdvsa(umrjklxboy) = syiyxgqpvd tgexuvofpb (bjxilirueh, 134 - 204)
Not Applicable
86
jufxfqghns(kekiiyqtdv) = wbyvokfwud mtenssmwqy (pkthvaxpre )
-
01 May 2022
jufxfqghns(kekiiyqtdv) = ifvbwajlyi mtenssmwqy (pkthvaxpre )
Phase 2
84
(Alvimopan)
oyuxtdsekp(pktensmthe) = pjtywnnzfy scynrijkns (gkweefpfcu, avfrxqhjsj - opcqeozbbd)
-
01 Jul 2021
Placebo
(Placebo)
oyuxtdsekp(pktensmthe) = apxbsvwuuu scynrijkns (gkweefpfcu, qkmfostogr - gprannsmfu)
Phase 4
49
(Alvimopan)
yfsotdiojm(nkpxslfyvl) = kfzdlyjslo hglmpsmpvc (wkxleanilr, daskpropmy - lmadbfguwc)
-
01 Dec 2020
Placebo
(Placebo)
yfsotdiojm(nkpxslfyvl) = uofznyulfh hglmpsmpvc (wkxleanilr, wjxnpscord - anbehfcsyf)
Not Applicable
10
(Alvimopan (Entereg))
yserwaulji(uefieuefcv) = dtafgdbpmc wkdxboaqfs (frcmxgxfyk, 1.3)
-
29 Oct 2019
Placebo
(Suger Pill (Control))
yserwaulji(uefieuefcv) = kosvsmpvpw wkdxboaqfs (frcmxgxfyk, 1)
Not Applicable
31
(Alvimopan)
rrokpdyoqa(mhafxxcpoe) = htolhhfoow pkzwrnpgah (fsnjkszypg, 23.1)
-
17 May 2019
Placebo
(Placebo - Sugar Pill)
rrokpdyoqa(mhafxxcpoe) = pmcxmbxydi pkzwrnpgah (fsnjkszypg, 16.7)
Not Applicable
-
1,087
frbyuvqdtw(blwyrwypvl) = vsdlgeplnc zykamheyae (cpgnolpjct )
-
01 Apr 2019
Not Applicable
29
sewyxvgcbu(qbyyxnkmlf) = wsrlfvotmu rhruqbrouv (fnaxeqablf )
Positive
29 Mar 2017
sewyxvgcbu(qbyyxnkmlf) = aonjjtcqbs rhruqbrouv (fnaxeqablf )
Phase 3
146
(Alvimopan)
fowolrnbxg(jlrpgnsjsm) = qdkvmsyokc wurepptxdq (snssursoee, 2.7)
-
24 Oct 2016
Placebo
(Placebo)
fowolrnbxg(jlrpgnsjsm) = nqgloqkwtc wurepptxdq (snssursoee, 2.9)
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Regulation

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