Last update 10 Dec 2024

JRF-104

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
JRF 104, JRF104, XH-30002
Target
AXL x CDK4 x FLT3
Mechanism
AXL inhibitors(AXL receptor tyrosine kinase inhibitors), CDK4 inhibitors(Cyclin-dependent kinase 4 inhibitors), FLT3 inhibitors(Tyrosine-protein kinase receptor FLT3 inhibitors)
Therapeutic Areas
NeoplasmsDigestive System DisordersHemic and Lymphatic Diseases
Active Indication
Advanced Malignant Solid NeoplasmEsophageal CarcinomaAcute Myeloid Leukemia
Inactive Indication-
Originator Organization
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
Active Organization
WuXi AppTec (Shanghai) Co. Ltd.WuXi AppTec (Shanghai) Co. Ltd.Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., LtdWuXi AppTec (Wuhan) Co., Ltd.WuXi AppTec (Wuhan) Co., Ltd.
+ [1]
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
Login to view timeline

Related

3
Clinical Trials associated with JRF-104
NCT05927844 / Not yet recruitingPhase 1IIT
An Open, Single-arm, Multicenter Phase Ib Clinical Study of XH-30002 Capsule Combined With Afatinib Tablets for the Treatment of Locally Advanced or Metastatic Esophageal Squamous Cell Carcinoma
CTR20202519 / RecruitingPhase 1
一项评价XH-30002胶囊口服给药在晚期实体瘤患者中的安全性、耐受性、药代动力学特征和初步疗效的Ⅰ期临床研究
[Translation] A Phase I clinical study to evaluate the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of oral XH-30002 capsules in patients with advanced solid tumors
ChiCTR2100043865 / RecruitingPhase 1IIT
A phase I clinical study evaluating the safety, tolerability, pharmacokinetic characteristics and preliminary efficacy of XH-30002 capsules administered orally in patients with advanced solid tumors
100 Clinical Results associated with JRF-104
Login to view more data
100 Translational Medicine associated with JRF-104
Login to view more data
100 Patents (Medical) associated with JRF-104
Login to view more data
100 Deals associated with JRF-104
Login to view more data

R&D Status

10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
CN
Shanghai Xunhe Pharmaceutical Technology Co., LtdShanghai Xunhe Pharmaceutical Technology Co., Ltd
16 Aug 2021
Esophageal CarcinomaPreclinical
CN
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
15 Aug 2024
Acute Myeloid LeukemiaPreclinical
CN
Chengdu Jinruijiye Biotechnology Co., LtdChengdu Jinruijiye Biotechnology Co., Ltd
15 Aug 2020
Acute Myeloid LeukemiaPreclinical
CN
WuXi AppTec (Shanghai) Co. Ltd.WuXi AppTec (Shanghai) Co. Ltd.
15 Aug 2020
Acute Myeloid LeukemiaPreclinical
CN
WuXi AppTec (Wuhan) Co., Ltd.WuXi AppTec (Wuhan) Co., Ltd.
15 Aug 2020
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
login
or
view full example data
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
login
or
view full example data
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
login
or
view full example data
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
login
or
view full example data
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
login
or
view full example data
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
login
or
view full example data
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free