[Translation] A randomized, double-blind, single-center, placebo-controlled, dose-escalation Phase I clinical study to evaluate the safety, tolerability, and pharmacokinetics of a single dose of XH-6003 injection in healthy Chinese adult subjects
(1)评估XH-6003注射液在中国健康受试者中单次给药的安全性和耐受性,确定最大耐受剂量。
(2)考察XH-6003注射液在中国健康受试者中单次给药后的XH-6003和XH-6003主要代谢产物(XH-6003-M)的药代动力学(PK)及药效学(PD)特征。
[Translation] (1) Evaluate the safety and tolerability of a single dose of XH-6003 injection in healthy Chinese subjects and determine the maximum tolerated dose.
(2) Investigate the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of XH-6003 and the main metabolite of XH-6003 (XH-6003-M) after a single dose of XH-6003 injection in healthy Chinese subjects.