Delving into the Latest Updates on Ferric ammonium citrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug, Diagnostic radiopharmaceuticals

Synonyms

Ferric ammonium citrate (JAN/USP), Ferric ammonium citrate, green

+ [3]

Target-

Action

modulators

Mechanism

Fe modulators

Therapeutic Areas

Digestive System DisordersEndocrinology and Metabolic DiseaseHemic and Lymphatic Diseases

Active Indication

Gastrointestinal DiseasesAnemia, Iron-Deficiency

Inactive Indication

Chronic Kidney DiseasesHyperphosphatemiaKidney Failure, Chronic

Originator Organization

Otsuka Pharmaceutical Co., Ltd.

Active Organization

Otsuka Pharmaceutical Co., Ltd.

Hunan Hansen Pharmaceutical Co. Ltd.

Inactive Organization

Sinomune Pharmaceutical Co., Ltd.

Nanjing Shenzhou Jiamei Pharmaceutical Co., Ltd.

Panion & BF Biotech, Inc.

+ [2]

Drug Highest PhaseApproved

First Approval Date

China (01 Jan 1982),

Anemia, Iron-Deficiency

Regulation-

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Structure/Sequence

Molecular FormulaC6H11FeNO7

InChIKeyPLKYGPRDCKGEJH-UHFFFAOYSA-N

CAS Registry1185-57-5

Antibiotics are widely used in health care to treat various infections.Excessive use and poor waste management make antibiotics a serious threat to aquatic ecosystems.Most of the ecotoxicol. assessments on freshwater microalgae are evaluated in the defined culture medium, which lacks environmental relevance.Hence, this study aimed to evaluate the toxicity of amoxicillin, ciprofloxacin, and levofloxacin on the freshwater microalga Scenedesmus obliquus in both lake water medium (LWM) and Blue green-11 medium (BG-11 M).Results indicated that levofloxacin exhibited the highest toxicity, followed by amoxicillin and ciprofloxacin in both LWM and BG-11 M.Pearson correlation and cluster heat map analyses revealed that oxidative stress generation was directly linked to reduced photosynthetic activity and cell viability.These findings suggest toxicity assessments conducted in defined culture media may modulate the toxicity levels compared to environmentally relevant media, like lake water.

01 Feb 2025·Environmental Pollution

Aquatic high iron induces hepatic ferroptosis in zebrafish (Danio rerio) via interleukin-22 signaling pathway

Article

Author: Ai, Qinghui ; Wan, Min ; Shi, Wenkai ; Chu, Ruixia ; Mai, Kangsen ; Feng, Wei ; Liao, Xinmeng ; Weng, Yizhuo ; Liang, Shufei

Iron is one of the indispensable trace elements in living organisms. However, excessive iron deposition in organisms is prone to induce dysfunction of the liver and other vital organs. The present study aimed to investigate the mechanism how aquatic high iron affects iron transport and induces hepatic injury in zebrafish. Our results showed that the iron levels in zebrafish liver and serum were significantly increased after the fish treated with aquatic high iron (200 mg/L ferric ammonium citrate, FAC) for 21 days. Meanwhile, hepatic fibrosis was observed in zebrafish with high iron treatment. Furthermore, the expression of hepcidin, a key factor in the regulation of iron homeostasis, as well as other factors related to iron transport, was significantly influenced by high iron treatment. Nonetheless, different tissues, such as liver, gill and gut, diversely responded to high iron in water. Interestingly, our results identified that the expression of IL-22, instead of IL-6, was significantly elevated after high iron treatment. Moreover, high iron triggered STAT3 phosphorylation via IL-22, leading to the augmented expression of hepcidin and hepatic iron accumulation. As a result, the iron overload in fish liver induced hepatic ferroptosis, marked as the repressed activity of glutathione peroxidase (GPx) and elevated lipid peroxidation. Further studies confirmed that, unlike wild-type (WT) zebrafish, the expression of hepcidin and iron content in the liver of il22-deficient zebrafish was unaffected upon to high iron treatment. At the meantime, hepatic ferroptosis and fibrosis induced by high iron was significantly alleviated in il22-deficient zebrafish. In summary, aquatic high iron induced hepcidin expression in zebrafish by activating the IL-22/STAT3 signaling pathway, which in turn regulated hepatic iron transport and ferroptosis in zebrafish. The present study identified for the first time that IL-22 may be a potential regulatory target for iron overload-induced liver injury.

01 Feb 2025·Journal of Environmental Management

Preparation of magnetic hydrophobic Cu+-containing mesoporous materials and their performance in adsorption and removal of organic sulfides from simulated gasoline

Article

Author: Cao, Lidan ; Chai, Yupei ; Zhang, Jielan ; Zhang, Yingxing ; Wang, Junhong ; Wu, Rui

Sulfur-containing gases produced during the utilization of petroleum fuels are the main cause of air pollution. To remove organic sulfur-containing compounds from simulated gasoline, magnetic hydrophobic Cu⁺-containing SBA-15 mesoporous molecular sieves (PMS-Cu⁺) were prepared by magnetization of the sample, loading and reduction of copper ion and hydrophobic treatment of the sample. The composition and structure of the synthesized composites were characterized by XRD, FTIR, SEM, TEM, and XPS, which proved the successful preparation of the adsorbent PMS-Cu⁺. In addition, it was also investigated on the adsorption capacity of the prepared adsorbent for organic sulfur compounds in simulated gasoline and the factors affecting the desulfurization performance. Through the kinetic study of the adsorption process, it was found that the process conformed to the quasi-secondary kinetic properties, the adsorption process was dominated by chemical adsorption, and internal and external diffusion co-determined the adsorption rate. Moreover, the apparent activation energy of the adsorption process was 50.83 kJ/mol.

100 Deals associated with Ferric ammonium citrate

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External Link

KEGG	Wiki	ATC	Drug Bank
D01644	Ferric ammonium citrate	V08CA07	DB09501

R&D Status

Approved

10 top approved records.

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Indication	Country/Location	Organization	Date
Gastrointestinal Diseases	Japan	Otsuka Pharmaceutical Co., Ltd.	02 Jul 1993
Anemia, Iron-Deficiency	China	Hunan Hansen Pharmaceutical Co. Ltd.	01 Jan 1982

Developing

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Hyperphosphatemia	Phase 2	China	Nanjing Shenzhou Jiamei Pharmaceutical Co., Ltd.	09 Jun 2018
Hyperphosphatemia	Phase 2	China	Jiangsu Carephar Pharmaceutical Co., Ltd.	09 Jun 2018
Anemia	Phase 1	China	Panion & BF Biotech, Inc.	14 Oct 2020
Chronic Kidney Diseases	Phase 1	China	Panion & BF Biotech, Inc.	05 Aug 2019
Chronic Kidney Diseases	Phase 1	China	Choice Pharm Med Info Consultancy (Shanghai Co. Ltd.	05 Aug 2019
Kidney Failure, Chronic	Phase 1	China	Sinomune Pharmaceutical Co., Ltd.	24 May 2019
Hyperphosphatemia	Phase 1	China	Nanjing Shenzhou Jiamei Pharmaceutical Co., Ltd.	09 Jun 2018
Hyperphosphatemia	Phase 1	China	Jiangsu Carephar Pharmaceutical Co., Ltd.	09 Jun 2018