Delving into the Latest Updates on Hunan Hansen Pharmaceutical Co. Ltd. with Synapse

Overview

Tags

Endocrinology and Metabolic Disease

Nervous System Diseases

Immune System Diseases

Herbal medicine

Small molecule drug

Diagnostic radiopharmaceuticals

Disease domain score

A glimpse into the focused therapeutic areas

Technology Platform

Most used technologies in drug development

Targets

Most frequently developed targets

Disease Domain	Count

Endocrinology and Metabolic Disease	2
Hemic and Lymphatic Diseases	1
Immune System Diseases	1
Nervous System Diseases	1

Top 5 Drug Type	Count

Small molecule drug	2
Herbal medicine	2
Diagnostic radiopharmaceuticals	1

Top 5 Target	Count

TPO(Thyroid peroxidase)	1

采用随机开放、四周期全重复、单剂量给药设计评价湖南汉森制药股份有限公司生产的卡马西平片（200mg/片）与Novartis Pharmaceuticals Corporation生产的卡马西平片（200mg/片，商品名：Tegretol®，中文名：得理多®）在中国健康人群空腹、餐后口服的生物等效性，为湖南汉森制药股份有限公司生产的卡马西平片与Novartis Pharmaceuticals Corporation生产的卡马西平片临床疗效的一致性提供证据。

[Translation]

A randomized open-label, four-period fully repeated, single-dose administration design was used to evaluate the bioequivalence of carbamazepine tablets (200 mg/tablet) produced by Hunan Hansen Pharmaceutical Co., Ltd. and carbamazepine tablets (200 mg/tablet, trade name: Tegretol®, Chinese name: Deliduo®) produced by Novartis Pharmaceuticals Corporation in healthy Chinese people when taken orally on an empty stomach or after a meal, providing evidence for the consistency of clinical efficacy of carbamazepine tablets produced by Hunan Hansen Pharmaceutical Co., Ltd. and carbamazepine tablets produced by Novartis Pharmaceuticals Corporation.

Start Date-

Sponsor / Collaborator

Hunan Hansen Pharmaceutical Co. Ltd.

CTR20230673 / Active, not recruitingNot Applicable

恩格列净片在中国健康受试者空腹和餐后状态下的单中心、随机、开放、两制剂、两周期、两序列、单次给药、双交叉生物等效性研究

[Translation] A single-center, randomized, open-label, two-dose, two-period, two-sequence, single-dose, double-crossover bioequivalence study of empagliflozin tablets in Chinese healthy subjects under fasting and fed conditions

以恩格列净的主要药代动力学参数（AUC和Cmax）为生物等效性的评价指标，在中国健康受试者空腹和餐后状态下评估受试制剂（湖南汉森制药股份有限公司生产的恩格列净片，规格25mg）和参比制剂（Boehringer Ingelheim Pharma GmbH & Co. KG生产的恩格列净片，规格25mg，商品名：Jardiance®）的生物等效性。观察空腹和餐后状态下口服受试制剂和参比制剂的安全性。

[Translation]

The main pharmacokinetic parameters (AUC and Cmax) of empagliflozin were used as bioequivalence evaluation indicators to evaluate the bioequivalence of the test formulation (empagliflozin tablets produced by Hunan Hansen Pharmaceutical Co., Ltd., specification 25 mg) and the reference formulation (empagliflozin tablets produced by Boehringer Ingelheim Pharma GmbH & Co. KG, specification 25 mg, trade name: Jardiance®) in Chinese healthy subjects in the fasting and fed state. The safety of oral administration of the test formulation and the reference formulation in the fasting and fed state was observed.

Start Date20 Dec 2022

Sponsor / Collaborator

Hunan Hansen Pharmaceutical Co. Ltd.

CTR20180521 / Completed

一项在中国健康志愿者中评估卡托普利片12.5mg的空腹生物等效性研究

[Translation] A fasting bioequivalence study evaluating captopril tablets 12.5 mg in healthy Chinese volunteers

采用随机开放、双周期交叉、单剂量给药设计评价湖南汉森制药股份有限公司生产的卡托普利片（12.5mg/片）与第一三共株式会社（Daiichi Sankyo Espha Co., Ltd.）生产的卡托普利片（12.5mg/片，商品名：CAPTORIL®）在中国健康人群的空腹生物等效性，为湖南汉森制药股份有限公司生产的卡托普利片与第一三共株式会社生产的卡托普利片临床疗效的一致性提供证据。

[Translation]

A randomized, open-label, two-period crossover, single-dose administration design was used to evaluate the fasting bioequivalence of captopril tablets (12.5 mg/tablet) produced by Hunan Hansen Pharmaceutical Co., Ltd. and captopril tablets (12.5 mg/tablet, trade name: CAPTORIL®) produced by Daiichi Sankyo Espha Co., Ltd. in healthy Chinese people, to provide evidence for the consistency of clinical efficacy of captopril tablets produced by Hunan Hansen Pharmaceutical Co., Ltd. and captopril tablets produced by Daiichi Sankyo Co., Ltd.

Start Date26 Apr 2018

Sponsor / Collaborator

Hunan Hansen Pharmaceutical Co. Ltd.

100 Clinical Results associated with Hunan Hansen Pharmaceutical Co. Ltd.

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0 Patents (Medical) associated with Hunan Hansen Pharmaceutical Co. Ltd.

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3

Literatures (Medical) associated with Hunan Hansen Pharmaceutical Co. Ltd.

Yaowu Pingjia Yanjiu

Carcinogenesis of Simotang Oral Liquid in SD rats

Author: Du Mu ; Ma Jinling ; Zhang Sucai ; Tan Zeyun ; Wang Xifeng ; Yang Hua ; He Yanan ; Li Jingli ; Liu Zhengqing

Objective To study the carcinogenesis of Simotang Oral Liquid in SD rats.Methods Totally 600 SD rats were randomly divided into five groups, half male and half female in each group.They were neg. control group, adjuvant control group, low, middle and high dose group, Sterilized water for injection, adjuvant solution, 1, 5, 25 g/kg Simotang oral liquid were ig given resp., Once a day for 104 wk.The clin. observation, body weight, food intake, gross anatomy and histopathol. of animals were examined during the experimentCalculation of mortality and tumor incidence in rats.Results There was no significant difference in survival rate among the exptl. groups.No regular change of toxicol. significance was found in the tumors of each exptl. group.Histopathol. examination showed that there was no significant dose-dependent relationship between tumor occurrence in each dose group, the occurrence of tumor is also a common predictable or sporadic tumor in the 2-yr carcinogenesis test of SD rats, the occurrence of these tumors is not related to the given test article.There was no increase in the incidence of test article related non-tumor lesions in all drug groups.Conclusion Simotang oral liquid was not found carcinogenicity in SD rats.

Zhongguo Shiyan Fangjixue Zazhi

Determination of costunolide and dehydrocostuslactone in Aucklandiae radix produced in different areas and time by HPLC

Author: Liu, Zheng-qing

Costunolide and dehydrocostuslactone in Aucklandiae Radix produced in different areas and time by HPLC were detected.HPLC method was set up, column was Venusil XBP C₁₈, the mobile phase was methmol-water (65:35), with the flow rate of 1.0 mL·min^-1, the detection wavelength was at 225 nm, column temperature was at 30°C.Costunolide was linear within the range of 0.2-3.0 μg, the correlation coefficient r=0.9997; the average recovery was 99.27%.Dehydrocostuslactone was linear within the range of 0.2-3.0 μg, the correlation coefficient r=0.9998; the average recovery was 99.46%.Aucklandiae Radix harvested in Sept. to Dec. complies with pharmacopoeial standards, the quality of medicinal materials produced in Yunnan province in Oct. was the best.

Zhongguo Shiyan Fangjixue Zazhi

HPLC fingerprint investigation on water extract from Lindera aggregata

Author: Yang, Hua ; Yi, Yue-neng ; Liu, Zheng-qing

High-performance liquid chromatog. (HPLC) fingerprints of water extract from Lindera aggregata were established.The sample solution was prepared by boiling water, and HPLC was employed to sep. ingredients by gradient elution with mixture of acetonitrile and 0.1% formic acid and detected at 280 nm.The fingerprint data were analyzed by similarity evaluation, principal component anal., and cluster anal.Fifteen common peaks were defined in different fingerprints.The relative standard deviation (RSD) values of the relative retention time of 15 common peaks were small than 2%.The fingerprints established could be used for the quality control of L. aggregata with high stability and good reproducibility.

100 Deals associated with Hunan Hansen Pharmaceutical Co. Ltd.

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100 Translational Medicine associated with Hunan Hansen Pharmaceutical Co. Ltd.

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Pipeline

Pipeline Snapshot as of 23 Nov 2024

The statistics for drugs in the Pipeline is the current organization and its subsidiaries are counted as organizations,Early Phase 1 is incorporated into Phase 1, Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3

Approved

4

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Current Projects

Drug(Targets)	Indications	Global Highest Phase

Propylthiouracil ( TPO )	Hyperthyroidism More	Approved
Ferric ammonium citrate	Anemia, Iron-Deficiency More	Approved
TianMaXingNao	Sleep Initiation and Maintenance Disorders More	Approved
SiMoTang	Dyspepsia More	Approved