Delving into the Latest Updates on Clostridium Butyricum (Grand Life Science) with Synapse

Overview

Basic Info

Drug Type

Live biotherapeutic products

Synonyms

米桑

Target-

Mechanism

Bacteria replacements, Gastrointestinal microbiome modulators

Therapeutic Areas

Other Diseases

Active Indication

Acute diarrhea

Inactive Indication-

Originator Organization

Grand Life Science (Chongqing) Co., Ltd.

Active Organization

Grand Life Science (Chongqing) Co., Ltd.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

CN (01 Jan 2004),

Acute diarrhea

Regulation-

Login to view timeline

AbstractClostridium butyricum has been used as a probiotic in animals and humans for years, however, its fate in the intestine has not been clarified yet. We investigated the intestinal fate of C. butyricum using a selective medium and a monoclonal antibody after orally administering C. butyricum spores to rats. The number of C. butyricum, both viable and dead cells, in the intestinal contents were counted by enzyme‐linked immunosorbent assay (ELISA) at various times after a single oral administration. The total viable number of C. butyricum was counted using a selective medium, and viable resting spores were selectively detected by treating the samples with ethanol. To investigate the intraluminal localization of the C. butyricum cells, frozen intestinal tracts were imprinted onto slides and stained with immunogold‐silver. Total viable spores exceeded the number of viable resting spores by more than 10‐fold from the proximal to middle of the small intestine 30 min after administration. Vegetative cells of C. butyricum were first detected in the distal small intestine after 2 hr, and vegetative growth was observed from the cecum to the colon 5 hr after administration. Dead vegetative cells were detected 9 hr after administration, and C. butyricum cells were not detected in the intestine after 3 days. The C. butyricum cells in the intestinal imprints were stained specifically by immunogold‐silver staining, and proliferative cells were observed in the cecum after 3 hr. These results suggest that the administered C. butyricum germinated in the upper small intestine, grew mainly from the distal small intestine to the colon and were excreted from the rat intestine within 3 days.

100 Deals associated with Clostridium Butyricum (Grand Life Science)

Login to view more data

R&D Status

10 top approved records.

Login

to view more data

Indication	Country/Location	Organization	Date
Acute diarrhea	CN	Grand Life Science (Chongqing) Co., Ltd.	01 Jan 2004

Login to view more data

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


EHA2023	Not Applicable	Hematopoietic stem cell transplantation	38	CLOSTRIDIUM BUTYRICUM MIYAIRI 588 (Control group (Ctrl))	xykydwcdpo(sgkekemaff) = uwrnibwsri oynpkxhvwm (nyzeypgggv )	-	08 Jun 2023