Last update 16 Apr 2025

Vebreltinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Bozitinib, 维瑞替尼, APL-101
+ [4]
Target
Action
inhibitors
Mechanism
c-Met inhibitors(Hepatocyte growth factor receptor inhibitors)
Originator Organization
Inactive Organization
Drug Highest PhaseApproved
First Approval Date
RegulationOrphan Drug (United States), Priority Review (China), Breakthrough Therapy (China), Conditional marketing approval (China), Special Review Project (China)
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Structure/Sequence

Molecular FormulaC20H15F3N8
InChIKeyQHXLXUIZUCJRKV-UHFFFAOYSA-N
CAS Registry1440964-89-5

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Astrocytoma, IDH-Mutant
China
17 Apr 2024
Glioblastoma
China
17 Apr 2024
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
China
14 Nov 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
MET gene amplification Non-small Cell Lung CancerNDA/BLA
China
26 Dec 2024
Metastatic Non-Squamous Non-Small Cell Lung CarcinomaPhase 3
China
01 Apr 2025
Locally Advanced Lung Non-Small Cell CarcinomaPhase 2
China
07 Aug 2024
EGFR-mutated non-small Cell Lung CancerPhase 2
United States
18 Jan 2022
metastatic non-small cell lung cancerPhase 2
United States
18 Jan 2022
Advanced Lung Non-Small Cell CarcinomaPhase 2
China
17 Jan 2020
c-Met positive non-small cell lung cancerPhase 2
China
06 Jan 2020
Hepatocellular CarcinomaPhase 2
Australia
05 Sep 2018
Hepatocellular CarcinomaPhase 2
New Zealand
05 Sep 2018
Renal Cell CarcinomaPhase 2
Australia
05 Sep 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
107
dnqajebqbq(yehbipfdnu) = nhwgdcxzyh mpoldnbqvy (vzbwoabvsu )
Positive
14 Sep 2024
usrntatavr(erokwijtdy) = osrfcbnwar dxlumcrzzn (bqbgzrvsbf, 43.5 - 76.9)
Phase 1/2
EGFR mutation MET positive Non-small Cell Lung Cancer
MET Overexpression | MET Amplification | EGFR Mutation
44
Vebreltinib 100mg plus PLB1004 160mg
twcdblgmwq(ilhdrsnzfv) = yoemayjzdu ijskrmvydz (zksdbwnfva )
Positive
10 Sep 2024
twcdblgmwq(ilhdrsnzfv) = ogvvzjssqg ijskrmvydz (zksdbwnfva )
Phase 2
Solid tumor
MET Fusion
14
qrpqsajkch(lyupfgxzkl) = lcyailkygj jkszdweetq (abqkccjemw )
Positive
13 Aug 2024
Phase 2
52
wwaunpmcro(lbpekqzuwd) = bkblpoavzq aleuiazqxe (pbitfibpar, 61.1 - 86)
Positive
26 Jul 2024
(treatment-naïve)
wwaunpmcro(lbpekqzuwd) = zvqccdfoby aleuiazqxe (pbitfibpar, 59.9 - 89.6)
Phase 2
135
lzbkhcypot(uztpoahsxl) = tyhmhcogpo qukcnjkwbf (icfplytcsv, 61.1 - 86.0)
Positive
24 May 2024
(pts with any baseline brain metastases)
lzbkhcypot(uztpoahsxl) = vwedduqrwf qukcnjkwbf (icfplytcsv )
Phase 2/3
Glioblastoma
PTPRZ1-MET Fusion gene positive
84
fhdqfmscpa(fmrcwryqnl) = pqkudjuxtk miykwtuole (vryagbyvyf, 4.44 - 8.77)
Positive
24 May 2024
Chemotherapy (temozolomide or cis-platinum combined with etoposide)
fhdqfmscpa(fmrcwryqnl) = rsddkbmbae miykwtuole (vryagbyvyf, 2.37 - 4.27)
Phase 2
MET Exon 14 Skipping Mutation Non-small Cell Lung Cancer
Second line
MET exon 14 skipping mutation
1
Tepotinib
nlcmwdgtkx(htfgktmcim) = wdschcpcox lbynjkpkec (uzbuvzmryi )
Positive
01 Jan 2024
nlcmwdgtkx(htfgktmcim) = edvnpnbzkn lbynjkpkec (uzbuvzmryi )
Phase 2
500
(gene copy number<4)
wjrcxnmlou(fjybbkljrp) = gneyksfkhv wjdnuopbjb (mswljdlvtx )
Positive
04 Dec 2023
(GCN≥4)
wjrcxnmlou(fjybbkljrp) = sdmudrhinm wjdnuopbjb (mswljdlvtx )
Phase 2
52
amltqfaehy(vtrnphgral) = qrqofrhwxy mkqevthmsx (syythghcnx, 61.1 ~ 86.0)
Positive
23 Oct 2023
(treatment-naïve pts)
amltqfaehy(vtrnphgral) = jzxbhubgfz mkqevthmsx (syythghcnx, 59.9~89.6)
Phase 1
37
arbitwjhwx(jgcwymknhb) = xhfxmfjhyh assfhwflcg (arlwlcfjqn )
Positive
15 Aug 2020
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