Last update 01 Nov 2024
GST-HG131
Last update 01 Nov 2024
Overview
Basic Info
Drug Type Small molecule drug |
Synonyms |
Target |
Mechanism HBsAg inhibitors(HBsAg inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication- |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhasePhase 2 |
First Approval Date- |
Regulation- |
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Structure
Molecular FormulaC23H29NO7 |
InChIKeyPQMAMDUBYCMNAT-NRFANRHFSA-N |
CAS Registry2270215-69-3 |
Related
4
Clinical Trials associated with GST-HG131A Randomized, Double-blind, Placebo-controlled Phase IIa Clinical Study to Evaluate the Safety and Efficacy of GST-HG131 Tablets in Patients With Chronic Hepatitis B
评价GST-HG131片在慢性乙型肝炎患者中的安全性、有效性的随机、双盲、安慰剂对照的IIa期临床研究。
[Translation] A randomized, double-blind, placebo-controlled Phase IIa clinical study to evaluate the safety and efficacy of GST-HG131 tablets in patients with chronic hepatitis B.
评价GST-HG131片在健康受试者中单中心、随机、双盲、安慰剂对照的多剂量、单次给药、多次给药的安全性、耐受性及药代动力学Ⅰa期临床试验
[Translation] A single-center, randomized, double-blind, placebo-controlled, multiple-dose, single-dose, and multiple-dose Phase Ia clinical trial to evaluate the safety, tolerability, and pharmacokinetics of GST-HG131 tablets in healthy subjects
100 Clinical Results associated with GST-HG131
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100 Translational Medicine associated with GST-HG131
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100 Patents (Medical) associated with GST-HG131
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2
Literatures (Medical) associated with GST-HG13101 Nov 2022Bioorganic & Medicinal Chemistry Letters
Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection
Article
Author: Li, Jian ; Chen, Shuhui ; Mao, John ; Wang, Qian ; Du, Jinhua ; Zhou, Qiong ; Qin, Shaohua ; Fan, Lirong ; Sun, Ya ; Zhang, George ; Wang, Lina ; Zhou, Qiaoyun ; Du, Xiaoting ; He, Shibo ; Ding, Charles Z ; Zhou, Yixin ; Hu, Lihong ; Hu, Yanbin ; Gu, Zhengxian ; Yuan, Qiang ; Wu, Wenqiang ; Sun, Fei
17 May 2022Antimicrobial Agents and ChemotherapyQ2 · MEDICINE
Safety, Tolerability, and Pharmacokinetics of the Novel Hepatitis B Virus Expression Inhibitor GST-HG131 in Healthy Chinese Subjects: a First-in-Human Single- and Multiple-Dose Escalation Trial
Q2 · MEDICINE
Article
Author: Wang, Meng ; Yan, Wenhao ; Gao, Lei ; Yao, Hanxin ; Hu, Yanbin ; Liu, Yusi ; Lou, Jinfeng ; Ding, Charles ; Tang, Yanan ; Li, Xiaojiao ; Mao, John ; Zhou, Yixin ; Ding, Yanhua ; Chen, Shuhui ; Wu, Wenqiang ; Niu, Junqi
100 Deals associated with GST-HG131
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R&D Status
10 top R&D records. to view more data
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| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Hepatitis B, Chronic | Phase 2 | CN | 26 Dec 2023 |
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Clinical Result
Clinical Result
Indication
Phase
Evaluation
View All Results
Phase 1 | - | - | (single-ascending-dose) | (ninhfahdov) = tomzlvetmc cnxegvqnch (gauzkiemyw ) View more | Positive | 17 May 2022 | |
(multiple-ascending-dose) | - |
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