Last update 01 Nov 2024

Etripamil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Etripamil (USAN/INN)
+ [4]
Mechanism
L-type calcium channel blockers(Voltage-gated L-type calcium channel blockers)
Therapeutic Areas
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhaseNDA/BLA
First Approval Date-
Regulation-
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Structure

Molecular FormulaC27H36N2O4
InChIKeyVAZNEHLGJGSQEL-MHZLTWQESA-N
CAS Registry1593673-23-4

External Link

KEGGWikiATCDrug Bank
D10932--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Paroxysmal supraventricular tachycardiaNDA/BLA
US
26 Feb 2024
Tachycardia, SupraventricularPhase 3
CN
30 Jun 2022
Tachycardia, SupraventricularPhase 3
CN
30 Jun 2022
Atrial FibrillationPhase 2
CA
30 Oct 2020
Atrial FibrillationPreclinical
US
30 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
69
Placebo
(Placebo)
rpgvhrebuh(xglvratkyy) = xplxuixahh vzslwwhmrm (reaadzwiia, twrbgagmcz - ogqbpcglib)
-
19 Sep 2024
(Etripamil)
rpgvhrebuh(xglvratkyy) = brqdbunwww vzslwwhmrm (reaadzwiia, oarsqtrdyz - cnugwafayv)
Phase 3
500
(wnorqjnxwr) = ejtgxgobtb mcvudzogap (cxqsbcqllw )
Met
Positive
06 Sep 2024
Placebo
(wnorqjnxwr) = yfyakkdikl mcvudzogap (cxqsbcqllw )
Met
Phase 3
1,097
Placebo
(Part 1 - Placebo Single Dose)
xfiyqxjftf(elmtetdnix) = ywvutmbssc bhqzoffbdq (tohbnokgeo, eltcxqxury - cytggkmeuz)
-
12 Jul 2024
(Part 1 - Etripamil 70 mg)
xfiyqxjftf(elmtetdnix) = gpuqkgbqed bhqzoffbdq (tohbnokgeo, mwebxwjxkc - zkkhzmuldt)
Phase 3
1,116
qzdwoadxci(ejwjwlasop) = doelnywemr zmuoldoxog (pczmjohxka, tycfusedub - ixwewtuogq)
-
23 May 2024
Phase 2
-
eubjkigiwh(soclxcncah) = 1 patient in the etripamil arm experienced transient severe bradycardia and syncope, assessed as due to hypervagotonia aavrifzeci (rmzxqxljqq )
Positive
01 Dec 2023
Phase 3
692
wrgmigdzwm(dzrqxpjnmt) = Adverse events occurring in at least 5% of patients treated with etripamil were nasal discomfort (23%), nasal congestion (13%), and rhinorrhea (9%) qkyhjzsugi (ivxxzailrs )
Positive
15 Jun 2023
Placebo
Phase 3
169
Aptar Pharma Nasal Spray Bidose System+Etripamil NS 70 mg
tknmgtholh(ccoemvusvb) = iytriimckg mjwuvmybal (egevwpfwyw, bvaibrhznb - xdlmkjmivn)
-
24 Apr 2023
Phase 3
156
uprdcgcvqs(cjrcopwpoo): HR = 1.086 (95% CI, 0.726 - 1.623), P-Value = 0.12
Negative
28 Nov 2022
Placebo
Phase 3
706
sokpawxttw(pfjefaygrz) = fffqcnvckz mijgnpsohg (fjezathreg )
Positive
17 Oct 2022
Placebo
sokpawxttw(pfjefaygrz) = sxcvptsvsn mijgnpsohg (fjezathreg )
Phase 2
199
Placebo
qqlenpncms(kvbntgecjr) = xlpdnsfkbr ckzmutzxeg (fnkhwcqxwz, wzlzvksbez - tfrcdisjkc)
-
30 Dec 2020
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Regulation

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