BACKGROUNDAlthough the use of brain health dietary supplements (brain DS) has increased, there is limited research on safety and risk of these products. Brain DS may be beneficial for improving memory, concentration, and focus but may also carry risks.OBJECTIVESTo assess brain DS users' utilization experiences and identify factors associated with likelihood of brain DS use among nonusers.DESIGNAn internet-based cross-sectional survey study was conducted using a sample of middle-aged US adults. Respondents' sociodemographic characteristics and health beliefs regarding brain DS were collected. Brain DS users' utilization experiences such as negative side effects and spending were also collected.PARTICIPANTS AND SETTINGPurposive sampling was utilized for users and nonusers sample recruitment.MAIN OUTCOME MEASURESBrain DS users' utilization experience and future likelihood of brain DS use among nonusers.STATISTICAL ANALYSES PERFORMEDDescriptive statistics on brain DS users' utilization experiences were reported. Ordinal logistic regression with sociodemographic and belief characteristics as predictors was employed to identify factors associated with the likelihood of brain DS among nonusers.RESULTSFive hundred twenty-five respondents (mean age = 43.8 ± 9.2 years) completed the survey. Among 260 users, primary reasons for use were enhancing memory (n = 136) and helping concentration and focus (n = 108). During the past year, 40% spent $50 to $200 (range = $0 to >$1,000) and 37% reported experiencing negative side effects. Among 265 nonusers, being female (odds ratio 2.04, 95% CI 1.21 to 3.45), perceived susceptibility to brain problems (odds ratio 1.90, 95% CI 1.28 to 2.83), recommendation from others (odds ratio 1.55, 95% CI 1.03 to 2.35) and perceived benefits of brain DS (odds ratio 2.82, 95% CI 1.60 to 4.96) were significantly associated with increased likelihood of future brain DS use.CONCLUSIONSIndividual spending on brain DS varies and about 40% of users reported experiencing negative side effects. As individuals primarily rely on healthcare providers for recommendations, health care providers should be prepared to engage in discussions about brain DS with patients.

15 Jul 2024·Environmental Technology

Highly efficient removal of diclofenac sodium with polystyrene supported ionic liquid

Article

Author: Zhang, Hao ; Li, Ruihua ; Du, Xin ; Cheng, Meng ; Zhang, Zihao

ABSTRACTDiclofenac sodium (DS) is now recognized as an emerging pollutant, and is one of the most commonly discovered pharmaceuticals in water due to its extensive application in the clinic. This study examined the adsorption performance of a polystyrene-supported ionic liquid material (PS-[Nim][Cl]) for the removal of diclofenac sodium (DS) from water. The data from this study showed that maximum removal of DS can be achieved even in conditions with significant pH and temperature fluctuations. The adsorption process was rapid, more than 90% of DS could be removed within the first 10 min and adsorption equilibrium could be reached in just 30 min with a high removal efficiency (>99.9%). Adsorption reached saturation with a maximum adsorption capacity of approximately 785.2 mg/g. Moreover, the presence of K⁺, Na⁺, Ca²⁺, Mg²⁺, Cl^-, and H₂PO₄^- ions had little influence on DS adsorption, even when concentrations of these ions were 10,000 times higher than that of DS in water samples. The adsorbent also showed promising performance for the treatment of environmental water samples and groundwater containing DS.

01 Jul 2024·Food Chemistry

Dextran sulfate acting as a chaperone-like component on inhibition of amorphous aggregation and enhancing thermal stability of ovotransferrin

Article

Author: Lu, Jinming ; Liu, Jingbo ; Yuan, Yixin ; Pan, Fengguang ; Shang, Xiaomin ; Wu, Xinling ; Zhang, Ting ; Gong, Lingling ; Xu, Haojie

The tendency of ovotransferrin (OVT) to unfold and aggregate under 60 °C severely restricted sterilization temperature during egg processing. Searching for efficient strategies to improve OVT thermal stability is essential for improving egg product quality and processing suitability. Here, we investigated the effect of sulfate polysaccharide (dextran sulfate, DS) on heat-induced aggregation of OVT. We found that DS can effectively suppress amorphous aggregation of OVT at pH 7.0 after heating. Strikingly, the addition of 5 µM DS fully suppressed insoluble aggregates formation of 0.5 mg/mL OVT. Structure analysis confirmed that DS preserves nearly the entire secondary and tertiary structure of OVT during heating. The steric hindrance effect arising from strong electrostatic interactions between OVT and DS, coupled with reduced OVT hydrophobicity, is the underlying mechanism in suppressing protein-protein interactions, thus enhancing thermal stability. These findings suggest DS could act as protein stabilizers and chaperones, enhancing the thermostability of heat-sensitive proteins.

100 Deals associated with Esterified estrogens/Methyltestosterone

External Link

KEGG	Wiki	ATC	Drug Bank
-	-	G03EA01	-

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Hot Flashes	US	Solvay SA	-
Menopausal symptoms	-	-	-

Clinical Result

Indication

Phase

Evaluation

View All Results

Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


AAO2003	Not Applicable	Dry Eye Syndromes postmenopausal women	15	Estratest	(cmndqxoxvt) = bowaihnujc evqdugtpbu (nydukyrife )	Positive	17 Nov 2003

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Esterified estrogens/Methyltestosterone

Overview

Basic Info

Structure

Related

External Link

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation