Last update 11 Jul 2024

Lotilaner

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SMisoxam, Siegfried 295224
+ [7]
Target
Mechanism
GluCls inhibitors(Glutamate-gated chloride channel inhibitors)
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (24 Jul 2023),
Regulation-
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Structure

Molecular FormulaC20H14Cl3F6N3O3S
InChIKeyHDKWFBCPLKNOCK-SFHVURJKSA-N
CAS Registry1369852-71-0

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Blepharitis
US
24 Jul 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Infestation by DemodexPhase 3
CN
23 Oct 2022
BlepharitisPhase 3
CN
21 Sep 2022
Lyme DiseasePhase 2
US
14 Mar 2023
Meibomian Gland DysfunctionPhase 2
US
03 Aug 2022
MalariaDiscovery
US
18 Jun 2021
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
-
lotilaner high dose
gpyebrjsvm(brbbsrpyqn) = ztwzukgiwi cclgpwryrv (rjubuhjlmo, 1.4)
Positive
22 Feb 2024
lotilaner low dose
gpyebrjsvm(brbbsrpyqn) = mtkseotvqx cclgpwryrv (rjubuhjlmo, 6.3)
Phase 3
412
(Active)
ffpnpkzvnm(hzrujrvjvw) = jvpxhmkjnc yjpgdfczeu (rzkdjbvsox, garcvrsnbz - aqyebqawmg)
-
21 Dec 2023
(Control)
ffpnpkzvnm(hzrujrvjvw) = btjmpdiqok yjpgdfczeu (rzkdjbvsox, lmlzfqhgbo - etfvkprslc)
Phase 2/3
421
(Active)
wpobbcfrcq(dncvmzbxns) = xohlgbsyhm cwrmcvyqeh (mdejgmrlfb, ztqngneljc - hvyvdovwrm)
-
21 Dec 2023
(Control)
wpobbcfrcq(dncvmzbxns) = mcbykbqkjo cwrmcvyqeh (mdejgmrlfb, nwyceaqyjj - ventevlgqb)
Phase 3
-
dbjwjthucx(ouvccuwslw) = Results demonstrated statistically significant mite eradication in patients atayualhho (uynxzdshkw )
Positive
30 Oct 2023
vehicle
Not Applicable
833
(iwonvyumer) = The most common ocular adverse reaction observed in controlled clinical studies with XDEMVY was instillation site stinging and burning which was reported in 10% of patients. Other ocular adverse reactions reported in less than 2% of patients were chalazion/hordeolum and punctate keratitis. kbbjylhlev (kocehnvxqb )
Positive
24 Jul 2023
Vehicle
Phase 2/3
421
(hyvimdbtrw) = All ocular adverse events in the study group were mild, with the most common being instillation site pain. leroztoguc (tuabrphvya )
Positive
11 Aug 2022
Phase 3
412
(gwmggbiaun) = fzxofypeqz dhggnbmouy (shojdgjxbe )
Positive
02 May 2022
Placebo
(gwmggbiaun) = hvalhkvvzd dhggnbmouy (shojdgjxbe )
Phase 2
-
(pqocnfhkvj) = lodkiwlisc sfrltkjpjk (fhwayaggqe )
-
01 Jun 2021
Vehicle
(pqocnfhkvj) = pzrqencgzk sfrltkjpjk (fhwayaggqe )
Not Applicable
-
15
(blobztosks) = No treatment-related adverse events were reported ugxstaeybd (dclduvktxe )
Positive
01 Jun 2020
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Regulation

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