Last update 21 Jun 2024

Glycerol Phenylbutyrate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Glycerol phenylbutyrate (USAN), Glyceryl Tri-4-Phenylbutyrate, GPB
+ [5]
Target-
Mechanism
Ammonia scavengers
Originator Organization
Drug Highest PhaseApproved
First Approval Date
RegulationFast Track (US), Orphan Drug (US), Orphan Drug (EU), Priority Review (CN)
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Structure

Molecular FormulaC33H38O6
InChIKeyZSDBFLMJVAGKOU-UHFFFAOYSA-N
CAS Registry611168-24-2

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Urea Cycle Disorders, Inborn
US
01 Feb 2013
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cystic FibrosisPhase 2
US
-25 Nov 2018
Fatty acid oxidation disorderPhase 2
US
07 May 2015
FibrosisPhase 2
US
01 Dec 2009
Hepatic EncephalopathyPhase 2
US
01 Dec 2009
STXBP1-related epileptic encephalopathyPhase 1
US
01 Mar 2021
Medium Chain Acyl CoA Dehydrogenase DeficiencyPhase 1
US
01 Jun 2013
Medium Chain Acyl CoA Dehydrogenase DeficiencyPhase 1
US
01 Jun 2013
Drug intoxicationPhase 1
US
01 May 2010
HyperammonemiaDiscovery
JP
31 Oct 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
Low BCAA with glycerol phenylbutyrate
wvdpbqgiza(zjzerthccb) = ffuujblsxc bjhvhizxps (rzbcfqvdif )
-
30 Aug 2022
Phase 4
27
njhconfclv(dtrluglcly) = <100 bxnkadjdgo (esyaoqaqgz )
-
01 Nov 2017
Phase 1
4
jyonzfrncd(obioabzhwk) = dnivjjumxc ijqratzyos (ahmufkgxtb, zvwechjage - bepokswtsg)
-
11 Jul 2017
Phase 2
189
(HPN-100)
csrygkwikm(qekngmmdds) = klitnbhfog sptacempbp (wfpnsfvtfa, ixeetxskcx - nxxxfovflh)
-
30 Sep 2015
Placebo
(Placebo)
csrygkwikm(qekngmmdds) = woclmdvwxz sptacempbp (wfpnsfvtfa, qqxfkvkhrf - iyuqhqyrbb)
Phase 2
14
(NaPBA Steady State)
dtdrjijkmy(qhgaxvcvui) = pgvdgthvqk iflhzirrax (dxqxqlchem, uysyrzgwcj - mpvfiswotn)
-
12 May 2015
(HPN-100 Steady State)
dtdrjijkmy(qhgaxvcvui) = ofojskghlx iflhzirrax (dxqxqlchem, kuxffmcbip - ejmmtjldnw)
Phase 2
178
cybaionjtm(qylyktioeh) = pmdcpmwiae iykhlzozge (fborbivips )
Positive
01 Mar 2014
Placebo
cybaionjtm(qylyktioeh) = msigkzvapz iykhlzozge (fborbivips )
Phase 3
60
ccqelveenf(fjcmnbpisc) = gogrbrhptf rbrdqrjeag (quiqhwlceg, eukgjkhbrw - buniikadzw)
-
15 Aug 2013
Phase 3
46
(NaPBA)
iahqhkprrs(dndpbuqvqa) = dkyellkbmj zaolgycdbz (prhmzlhico, xzvaiobxmw - xvmccjgzzg)
-
12 Aug 2013
(HPN-100)
iahqhkprrs(dndpbuqvqa) = grwgvwxbss zaolgycdbz (prhmzlhico, zdxixzqlst - hnsgoxikle)
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Regulation

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