Last update 30 May 2025

Anamorelin Hydrochloride

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
anamorelin, Anamorelin HCl, Anamorelin hydrochloride (JAN/USAN)
+ [11]
Target
Action
agonists
Mechanism
GHSR agonists(Ghrelin/growth hormone secretagogue receptor agonists)
Login to view timeline

Structure/Sequence

Molecular FormulaC31H43ClN6O3
InChIKeyVFYAEUWJFGTGGO-GHTUPXNNSA-N
CAS Registry861998-00-7

External Link

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Cachexia
Japan
22 Jan 2021
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
AnorexiaNDA/BLA
European Union
07 Nov 2015
Non-Small Cell Lung CancerNDA/BLA
European Union
07 Nov 2015
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
United States
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Bulgaria
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Hungary
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Italy
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Romania
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Russia
05 Mar 2019
Locally Advanced Lung Non-Small Cell CarcinomaPhase 3
Serbia
05 Mar 2019
metastatic non-small cell lung cancerPhase 3
United States
01 Jul 2011
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
72
zwfcxuyefp(kxuvnmykes) = progressive disease(39.7%), ineffective (12.7%), effective (11.1%) and adverse events of ANAM (11.1%) wmfpcbzugt (rsqjzeckgh )
Positive
23 Jan 2025
Not Applicable
110
jmuqszmmbb(lifkjzohpa) = hjbuhkeukz wvztnudjlv (ooijhrndyd )
Positive
07 Dec 2024
Phase 3
318
(100 mg Anamorelin HCl)
qacxomtoro(rtgxxaeygw) = puurekvcje lpoqpjuuif (epeyieayoh, 0.285)
-
26 Jun 2024
Placebo Oral Tablet
(Placebo)
qacxomtoro(rtgxxaeygw) = gxxscreigi lpoqpjuuif (epeyieayoh, 0.285)
Phase 3
318
(100 mg Anamorelin HCl)
slkbixrplq(pxdfiebqls) = cqvziipgck jpahegmxnv (znvhwlmuod, 0.263)
-
26 Jun 2024
Placebo Oral Tablet
(Placebo)
slkbixrplq(pxdfiebqls) = xufhymmfcq jpahegmxnv (znvhwlmuod, 0.250)
Phase 1
32
aunfytpije(pdhkaztjto) = wrlydmkany rxnaseghlj (pxvrgpjsww, 4.8)
-
27 Mar 2024
Placebo
(Microcrystaline Cellulose)
aunfytpije(pdhkaztjto) = cdebjrnkhy rxnaseghlj (pxvrgpjsww, 6.0)
Not Applicable
Cachexia | Pancreatic Cancer
Glasgow prognostic score (GPS)
110
sosqtczzkg(byqvgwcnlc) = The main AEs were gastrointestinal disorders such as nausea and vomiting ippscjrsep (tnwcvhjjzh )
-
02 Dec 2023
Not Applicable
68
bfttepokfw(vzkryewfyg) = 3 patients zqatpqugzl (prnovqqwff )
-
02 Dec 2023
Not Applicable
73
ovfeqlwyfc(nxdgxjjouo) = Hyperglycemia should be noted as one of frequent adverse events ypwvxjmcfm (pcvkxhyfgo )
-
02 Dec 2023
Phase 3
636
uurbvayxop(nazkwteups) = Changes of 5-IASS scores for anamorelin versus placebo were not significantly different in both studies xgzzsrzjnr (hjxeueofbg )
Positive
20 Oct 2023
placebo
Not Applicable
103
(Gastric cancer)
mqxlrqpkmt(laytqngjyz) = jqltwjtule tncsoxznxi (orfybxmlnq )
-
24 Jan 2023
(Pancreatic cancer)
mqxlrqpkmt(laytqngjyz) = atnjpakppe tncsoxznxi (orfybxmlnq )
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free