Last update 27 Feb 2026

VMD-928

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VMD 928
Target
TrkA
Action
antagonists
Mechanism
TrkA antagonists(Nerve growth factor receptor Trk-A antagonists)
Therapeutic Areas
NeoplasmsImmune System DiseasesDigestive System Disorders+ [5]
Active Indication
Adenoid Cystic CarcinomaAdvanced Head and Neck CarcinomaEsophageal Carcinoma+ [11]
Inactive Indication-
Originator Organization
VM Oncology LLC
Active Organization
VM Oncology LLC
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with VMD-928
NCT03556228
/ RecruitingPhase 1/2
A Phase 1/2 Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 as Monotherapy and in Combination With Pembrolizumab in Subjects With Solid Tumors or Lymphoma
100 Clinical Results associated with VMD-928
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100 Translational Medicine associated with VMD-928
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100 Patents (Medical) associated with VMD-928
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100 Deals associated with VMD-928
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenoid Cystic CarcinomaPhase 2
United States
VM Oncology LLC
08 Jun 2018
Advanced Head and Neck CarcinomaPhase 2
United States
VM Oncology LLC
08 Jun 2018
Esophageal CarcinomaPhase 2
United States
VM Oncology LLC
08 Jun 2018
Lip NeoplasmsPhase 2
United States
VM Oncology LLC
08 Jun 2018
LymphomaPhase 2
United States
VM Oncology LLC
08 Jun 2018
MesotheliomaPhase 2
United States
VM Oncology LLC
08 Jun 2018
Nasopharyngeal NeoplasmsPhase 2
United States
VM Oncology LLC
08 Jun 2018
Non-Small Cell Lung CancerPhase 2
United States
VM Oncology LLC
08 Jun 2018
Oropharyngeal NeoplasmsPhase 2
United States
VM Oncology LLC
08 Jun 2018
Pancreatic CancerPhase 2
United States
VM Oncology LLC
08 Jun 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03556228 (ASCO 12021 | ASCO 22021)
ManualManual
Phase 1
Solid tumor | Lymphoma
TRKA Overexpression
20
auyxsqzvlc(uxfzgvauqg) = The recommended phase 2 dose (RP2D) is 600 mg twice (1200 mg) per day. vjpstsmclp (jlswuqkjow )
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Positive
20 May 2021
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Translational Medicine

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Deal

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Clinical Trial

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Approval

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Regulation

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