Last update 30 Jun 2024

VMD-928

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
VMD 928
Target
TrkA
Mechanism
TrkA antagonists(Nerve growth factor receptor Trk-A antagonists)
Therapeutic Areas
NeoplasmsImmune System DiseasesDigestive System Disorders+ [6]
Active Indication
Adenoid Cystic CarcinomaAdvanced Head and Neck CarcinomaBladder Cancer+ [10]
Inactive Indication-
Originator Organization
VM Oncology LLC
Active Organization
VM Oncology LLC
Inactive Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-

Related

1
Clinical Trials associated with VMD-928
NCT03556228 / RecruitingPhase 1
An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 in Subjects With Solid Tumors or Lymphoma
100 Clinical Results associated with VMD-928
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100 Translational Medicine associated with VMD-928
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100 Patents (Medical) associated with VMD-928
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100 Deals associated with VMD-928
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Adenoid Cystic CarcinomaPhase 1
US
VM Oncology LLC
08 Jun 2018
Adenoid Cystic CarcinomaPhase 1
PR
VM Oncology LLC
08 Jun 2018
Advanced Head and Neck CarcinomaPhase 1
US
VM Oncology LLC
08 Jun 2018
Advanced Head and Neck CarcinomaPhase 1
PR
VM Oncology LLC
08 Jun 2018
Bladder CancerPhase 1
US
VM Oncology LLC
08 Jun 2018
Bladder CancerPhase 1
PR
VM Oncology LLC
08 Jun 2018
Breast CancerPhase 1
US
VM Oncology LLC
08 Jun 2018
Breast CancerPhase 1
PR
VM Oncology LLC
08 Jun 2018
Esophageal CarcinomaPhase 1
US
VM Oncology LLC
08 Jun 2018
Esophageal CarcinomaPhase 1
PR
VM Oncology LLC
08 Jun 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
NCT03556228 (ASCO2021)
ManualManual
Phase 1
Solid tumor | Lymphoma
TRKA Overexpression
20
xlmvyaswei(hsdykoahhk) = The recommended phase 2 dose (RP2D) is 600 mg twice (1200 mg) per day. zzdqdbhjhr (xequkrpket )
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Positive
20 May 2021
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Translational Medicine

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Clinical Trial

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Approval

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Regulation

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