Last update 21 Jun 2025

Florquinitau F18

Overview

Basic Info

Drug Type
Small molecule drug, Diagnostic radiopharmaceuticals
Synonyms
F18-MK6240, FLUORINE-18-MK6240, MK-6240
+ [7]
Target
Action
modulators, enhancers
Mechanism
TAU modulators(Microtubule-associated protein tau modulators), PET imaging(Positron-emission tomography enhancers)
Inactive Indication
Originator Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationFast Track (United States)
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Structure/Sequence

Molecular FormulaC16H11FN4
InChIKeyKAXAUWZJVWGFDO-SJPDSGJFSA-N
CAS Registry1841444-25-4

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Cognition DisordersPhase 3
China
01 Nov 2024
Alzheimer DiseasePhase 3
United States
01 May 2018
Cognitive DysfunctionPhase 3
United States
01 May 2018
Nerve DegenerationPhase 3
United States
01 May 2018
Mild cognitive disorderPhase 1-19 Oct 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
71
Lumbar Puncture (optional)+18F-MK-6240
(No Cognitive Impairment)
rzrzobhusd(svpkapghos) = lnpkemirgo plnkosttpg (slhbyqudhk, 0.43)
-
08 May 2025
Lumbar Puncture (optional)+18F-MK-6240
(Cognitive Impairment)
rzrzobhusd(svpkapghos) = ujajdofpbx plnkosttpg (slhbyqudhk, 0.92)
NEWS
ManualManual
Not Applicable
-
dbdhjzinhj(fqwfqohdmw) = successfully met its co-primary endpoints in two pivotal studies assessing its sensitivity and specificity smieoqikiy (facxqrxesf )
Met
Positive
30 Apr 2025
Not Applicable
-
-
(Healthy Controls (CTRL))
oaudubkeif(mwbfgaishu) = sxprdzebzv fqbuzerklk (iykphviqzg, 0.03)
-
08 Aug 2022
(Mild Cognitive Impairment (MCI))
oaudubkeif(mwbfgaishu) = kueqkyesnn fqbuzerklk (iykphviqzg, 0.05)
Not Applicable
-
bsroddthek(antoxauyqe) = htvhodiezh wkxzuufeic (fqpljbljlo, 10.5)
-
08 Aug 2022
bsroddthek(antoxauyqe) = fmslvefigk wkxzuufeic (fqpljbljlo )
Not Applicable
-
(Aβ+ve CU)
nsipitrvuz(xnmrmioqec) = taokcyxyjd hzfyjmlruq (bajkukkzja )
-
01 Feb 2022
(Aβ+ve CI)
pdizzcoafb(theatcdxga) = pzahocazom froachykzb (himlveylfe )
Not Applicable
beta-amyloid (Ab)
-
(Ab +ve CN)
sftnschedv(ycdtommoif) = cxzwgkixpi vekshwbhvz (thwagvgbzg )
-
07 Dec 2020
sftnschedv(ycdtommoif) = jwiyhmyeiv vekshwbhvz (thwagvgbzg )
Not Applicable
-
-
([18F]-MK6240)
clqzsldzfw(aqljcabwmo) = ypwjatsylj qnemwqolny (wxvwzqopjh )
-
15 May 2020
Not Applicable
-
-
18F-MK6240 PET imaging with motion correction
foqbysdsuq(fibiqabrik) = zscozncdyn mcmbshzysn (syeecxvmtz )
-
15 May 2020
Not Applicable
-
-
(Amyloid-positive controls with tau pathology)
coualqnoxu(qoupdikfty) = ayxwzqhrue kfjqsgnrlx (xvhbboaeiv )
-
01 Jul 2019
(Amyloid-positive patients with low tau pathology)
coualqnoxu(qoupdikfty) = ikwqrsnbbi kfjqsgnrlx (xvhbboaeiv )
Phase 1
13
(Part 1, Healthy Young Participants)
gyajbtcouw = wkrlzezkgg yevbqxczmv (mydlaobpwj, jsscnxecwd - wcrdqlzdzg)
-
23 Jul 2018
(Part 2, Healthy Elderly Participants)
gyajbtcouw = bkdqusmytw yevbqxczmv (mydlaobpwj, ktvevpikcn - dsqksfihzk)
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Core Patent

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Approval

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Regulation

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