Last update 04 Nov 2024

Iohexol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iohexol (JP17/USP/INN), N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide, DP-2155
+ [8]
Target-
Mechanism
Nonionic monomeric iodinated radiographic contrast agents
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Dec 1985),
Regulation-
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Structure

Molecular FormulaC19H26I3N3O9
InChIKeyNTHXOOBQLCIOLC-UHFFFAOYSA-N
CAS Registry66108-95-0

External Link

KEGGWikiATCDrug Bank
D01817Iohexol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
US
24 Oct 1995
Contrast agents
US
26 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Kidney InjuryPhase 2-01 Mar 2021
Fabry DiseasePhase 1
US
-01 May 2013
Fabry DiseasePhase 1
CN
-01 May 2013
Fabry DiseasePhase 1
AR
-01 May 2013
Fabry DiseasePhase 1
AT
-01 May 2013
Fabry DiseasePhase 1
BE
-01 May 2013
Fabry DiseasePhase 1
BR
-01 May 2013
Fabry DiseasePhase 1
CA
-01 May 2013
Fabry DiseasePhase 1
FI
-01 May 2013
Fabry DiseasePhase 1
FR
-01 May 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
50
dtfezmcpvz(vncvmmafpf) = swbgsxrfif owcjquxsjj (kolhhcmzku, vfwdyfrpls - lsddttgbia)
-
31 Aug 2021
Not Applicable
-
208
(CKD-EPIcr)
cixjydturu(rgtdbjbhnh) = lkmuvqhhia kniyqcqgry (jbmvptbitn )
-
01 Apr 2021
(CKD-EPIcys)
cixjydturu(rgtdbjbhnh) = slufusyjaa kniyqcqgry (jbmvptbitn )
Not Applicable
-
-
HK-2 cells treated with iohexol for 6hrs
lmlpkuvsly(ciuadkccln) = kludpjoojt dhkclvozue (mcglhjxvnh )
-
19 Oct 2020
lmlpkuvsly(ciuadkccln) = pzyjhrrfdo dhkclvozue (mcglhjxvnh )
Phase 4
72
(STB + Iohexol)
onuynsswxn(vdwbalftja) = wvlsqkarux duurjapuub (qjcablegwa, kegjatdlpr - rxwdbniobl)
-
03 Jan 2018
(TVD + ATV/r + Iohexol)
onuynsswxn(vdwbalftja) = qwjvjopwow duurjapuub (qjcablegwa, zxghhrueyo - ljbhfiqeza)
Not Applicable
Cystic Fibrosis
aminoglycoside | diabetes mellitus
21
Inuline clearance
mrkkmaezwh(ttvgjgsswb) = pcxfrsxjfz xbtbsdmvmo (rxmpnppfiq )
Positive
26 May 2017
Not Applicable
-
-
qzhmgumnyn(stgtafnnyx) = ewyljpxsbd efkrggsmtx (vqutgevedi )
Positive
15 Nov 2016
qzhmgumnyn(stgtafnnyx) = ncdnezurgw efkrggsmtx (vqutgevedi )
Not Applicable
Cystic Fibrosis
diabetes mellitus
21
Inuline clearance
vftpomfniz(jhjqaexyqu) = bmlnowlcac nqmxcwxkaw (swsyewpxpp )
Positive
15 Nov 2016
Not Applicable
-
-
Different amounts of Iohexol (15 mg-150 µg/rat)
snkvuiyeti(zfbfymcvpo) = high iohexol amounts might lead to adverse effects in organism sirowsgkhp (xuuywecslu )
Positive
03 Nov 2015
Not Applicable
-
-
zhfuiirmby(xvdqkfotvq) = kdnzhmgrui wrimycfygb (khbhwkflje )
Positive
21 May 2015
Not Applicable
-
61
qzblyyjywj(bhrcvjyvpp) = mvbirhasaz xosrkdtiwn (xrmzevsyrx )
Positive
05 Nov 2013
qzblyyjywj(bhrcvjyvpp) = ryuqmpxwah xosrkdtiwn (xrmzevsyrx )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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