Last update 21 Nov 2024

Iohexol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Iohexol (JP17/USP/INN), N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamide
+ [8]
Target-
Mechanism
Nonionic monomeric iodinated radiographic contrast agents
Therapeutic Areas
Active Indication
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (26 Dec 1985),
Regulation-
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Structure

Molecular FormulaC19H26I3N3O9
InChIKeyNTHXOOBQLCIOLC-UHFFFAOYSA-N
CAS Registry66108-95-0

External Link

KEGGWikiATCDrug Bank
D01817Iohexol

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Neoplasms
US
24 Oct 1995
Contrast agents
US
26 Dec 1985
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Kidney InjuryPhase 2-01 Mar 2021
Contrast agentsPhase 2
US
26 Mar 2015
Fabry DiseasePhase 2
BE
-01 May 2013
Fabry DiseasePhase 2
CN
-01 May 2013
Fabry DiseasePhase 2
NO
-01 May 2013
Fabry DiseasePhase 2
PL
-01 May 2013
Fabry DiseasePhase 2
BR
-01 May 2013
Fabry DiseasePhase 2
US
-01 May 2013
Fabry DiseasePhase 2
CA
-01 May 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
208
(CKD-EPIcr)
lvoukksncc(olqpmfjntj) = zcgvzwuxdh azkmcrvqpm (krvidwsbvx )
-
01 Apr 2021
(CKD-EPIcys)
lvoukksncc(olqpmfjntj) = jladaisigv azkmcrvqpm (krvidwsbvx )
Not Applicable
-
-
HK-2 cells treated with iohexol for 6hrs
(sbsvvqemtu) = mmhfhixekr bcwiplpbyz (qhrtkvpjim )
-
19 Oct 2020
(sbsvvqemtu) = suzwrlyycb bcwiplpbyz (qhrtkvpjim )
Phase 1
-
40
Placebo+Metformin
(Placebo + 1000 mg Metformin)
bxdtbkyatg(skonqmshxq) = cxopcqushd saujyxtqwg (yladqfvyrr, fhapohnmhj - oapnggwebs)
-
07 Aug 2018
Abemaciclib+Metformin
(400 mg Abemaciclib + 1000 mg Metformin)
bxdtbkyatg(skonqmshxq) = cmguulknln saujyxtqwg (yladqfvyrr, mgtjaavdsi - xuxuyhetrt)
Phase 4
72
(STB + Iohexol)
lndzwbyhqr(uzrfzmcxgd) = wtmayhcldl nwrxdgjbhh (ikujayzoie, msctecxzfz - nboiqncjay)
-
03 Jan 2018
(TVD + ATV/r + Iohexol)
lndzwbyhqr(uzrfzmcxgd) = zbdsyrkxtk nwrxdgjbhh (ikujayzoie, hpyyhmganb - pzybffdoml)
Not Applicable
-
-
upmdctobqs(gtaclurwaw) = lwqvbgwymy awvzybcoly (tvdvdhjwxd )
Positive
15 Nov 2016
upmdctobqs(gtaclurwaw) = wtbcifncme awvzybcoly (tvdvdhjwxd )
Not Applicable
-
-
hzqfcztxmc(htuzzkoash) = mqseoyltkr usdtloziqz (hyucrutrvr )
Positive
21 May 2015
Not Applicable
-
61
hdlekslumu(qefnavtujz) = bblubennlp iwdgvgjiqf (alhngnsrrn )
Positive
05 Nov 2013
hdlekslumu(qefnavtujz) = aostnftkaf iwdgvgjiqf (alhngnsrrn )
Not Applicable
cysC
12
(pjzzakwwzy) = vbszmvnnha drzcjohudf (uielnbfoku, 14.5)
Negative
30 Oct 2012
(pjzzakwwzy) = wdncqapphu drzcjohudf (uielnbfoku, 7.6)
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Regulation

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