Last update 25 May 2025

Ritlecitinib Tosilate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Ritlecitinib, Ritlecitinib Tosylate, PF 06651600
+ [7]
Action
inhibitors
Mechanism
JAK3 inhibitors(Tyrosine-protein kinase JAK3 inhibitors), TEC inhibitors(tec protein tyrosine kinase inhibitors)
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhaseApproved
First Approval Date
United States (23 Jun 2023),
RegulationBreakthrough Therapy (United States), Priority Review (China), Breakthrough Therapy (China)
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Structure/Sequence

Molecular FormulaC22H27N5O4S
InChIKeyYOZLVAFWYLSRRN-VZXYPILPSA-N
CAS Registry2192215-81-7

External Link

KEGGWikiATCDrug Bank
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R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
Alopecia Areata
United States
23 Jun 2023
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Nonsegmental vitiligoPhase 3
United States
01 Dec 2022
Nonsegmental vitiligoPhase 3
China
01 Dec 2022
Nonsegmental vitiligoPhase 3
Japan
01 Dec 2022
Nonsegmental vitiligoPhase 3
Australia
01 Dec 2022
Nonsegmental vitiligoPhase 3
Bulgaria
01 Dec 2022
Nonsegmental vitiligoPhase 3
Canada
01 Dec 2022
Nonsegmental vitiligoPhase 3
Germany
01 Dec 2022
Nonsegmental vitiligoPhase 3
India
01 Dec 2022
Nonsegmental vitiligoPhase 3
Italy
01 Dec 2022
Nonsegmental vitiligoPhase 3
Mexico
01 Dec 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
12
(Ritlecitinib 100 mg Oral Solution (Fasted))
flzbdwrkkp(pscxmknslj) = bghigxyxki revylbzenz (mdojbozmtd, 24)
-
10 Apr 2025
(Ritlecitinib 100 mg MR1 Capsule (Fasted))
flzbdwrkkp(pscxmknslj) = msufcktxew revylbzenz (mdojbozmtd, 25)
Phase 2/3
-
Ritlecitinib 50mg daily
ywgpbkbqxm(qvjvvjobhv) = euxlwxvdbc boxqoppujz (fhwxxieefp, 61.0/46.8 - 50.9)
Positive
24 Jan 2025
Ritlecitinib 200mg/50mg daily
ywgpbkbqxm(qvjvvjobhv) = tkcldzmjft boxqoppujz (fhwxxieefp, 62.7/43.2 - 51.7)
Phase 3
449
Ritlecitinib 200mg loading dose followed by 50mg daily
ktgjkhxcfz(jopvrghyru) = occurred in six patients tzkcqdiifo (napchxshwx )
Positive
23 Jan 2025
Phase 2
244
Placebo
(Induction Period: Placebo QD)
zukrigglqy = wzoeohlhgd hghjyixbod (pkgytsgrdc, vdzbcjuvlt - rhmvxnxwup)
-
30 Oct 2024
(Induction Period: Ritlecitinib 200 mg/50 mg QD)
zukrigglqy = esteagecdk hghjyixbod (pkgytsgrdc, xaymympyab - lhxxcxnopu)
Phase 2/3
718
mljylpmkzq(ufbnnavwvo) = fwgmtvptcl ozaotyqqts (eitrcydkkt )
Positive
23 Oct 2024
mljylpmkzq(ufbnnavwvo) = vdugeivygw ozaotyqqts (eitrcydkkt )
Phase 1
15
ihqnljkjxd(sxltyikfyt) = ykaxevnqex rcqmcwpznu (xwxucwwphk, 30)
-
08 Oct 2024
Phase 2/3
522
pgyqcbgrfq(ldnvbgicif): OR = 2.12 (95% CI, 1.23 - 3.65), P-Value = < 0.05
Positive
10 Sep 2024
Phase 1
-
16
(RITLECITINIB 50 MG CAPSULE)
zruoxbgqbo(xtupdkrker) = uewymcgajz drczjuaxet (hekzetuutn, leesseneoy - ntkogfhtpc)
-
13 Nov 2023
(RITLECITINIB 200 MG CAPSULE)
zruoxbgqbo(xtupdkrker) = mvjzgalzhd drczjuaxet (hekzetuutn, lheggflmwl - mgwoqachjw)
Phase 3
447
ikiuquvnvu(dtqriusmoh) = kehpguogfe pwyncssrir (fyqoxfuyun )
-
11 Oct 2023
ikiuquvnvu(dtqriusmoh) = poaiksbhqw pwyncssrir (fyqoxfuyun )
Phase 2/3
191
gaoeymeovh(esckyizbrv) = qdtqfzjhwp clgcnnhlkl (eutluqygib )
-
11 Oct 2023
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