Drug Type Small molecule drug |
Synonyms Ritlecitinib, PF 06651600, PF 6651600 + [5] |
Target |
Mechanism JAK3 inhibitors(Tyrosine-protein kinase JAK3 inhibitors), TEC inhibitors(tec protein tyrosine kinase inhibitors) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization- |
Drug Highest PhaseApproved |
First Approval Date US (23 Jun 2023), |
RegulationBreakthrough Therapy (US), Priority Review (CN), Breakthrough Therapy (CN) |
Molecular FormulaC15H19N5O |
InChIKeyCBRJPFGIXUFMTM-WDEREUQCSA-N |
CAS Registry1792180-81-4 |
KEGG | Wiki | ATC | Drug Bank |
---|---|---|---|
- | - | - |
Indication | Country/Location | Organization | Date |
---|---|---|---|
Alopecia Areata | US | 23 Jun 2023 |
Indication | Highest Phase | Country/Location | Organization | Date |
---|---|---|---|---|
Nonsegmental vitiligo | Phase 3 | US | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | CN | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | JP | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | AU | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | BG | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | CA | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | DE | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | IN | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | IT | 01 Dec 2022 | |
Nonsegmental vitiligo | Phase 3 | MX | 01 Dec 2022 |
Phase 2/3 | 191 | Ritlecitinib 50mg QD | ltwawgybbk(tbasntmwkr) = lhpkwlpngz wfvbykzdzu (qyhrsjkpwa ) View more | - | 11 Oct 2023 | ||
Phase 3 | 447 | Ritlecitinib 200 mg | untgnvsdxc(nmwrgxrugn) = szxqnwcqok jxcdkqjzgd (xqvqutwkai ) View more | - | 11 Oct 2023 | ||
Ritlecitinib 50 mg | untgnvsdxc(nmwrgxrugn) = hldxulvevz jxcdkqjzgd (xqvqutwkai ) View more | ||||||
Phase 1 | - | 12 | (Treatment A: Ritlecitinib 30 mg Intact Adult Capsule) | lwmkjlddta(fujrcyalhw) = sougreyhki khhzfenqge (tvrmvtvydc, xpwzulvfjt - wwdfrppzui) View more | - | 21 Aug 2023 | |
(Treatment B: Ritlecitinib 3*10 mg Pediatric Capsules) | lwmkjlddta(fujrcyalhw) = mitlxcwuwf khhzfenqge (tvrmvtvydc, mpgewdrlbv - evgennjdgu) View more | ||||||
Phase 2/3 | 718 | skbhvvxekh(dazesmzbwh) = alpeiowcfa ukfswelivg (naclcemhyl ) View more | Positive | 06 Jul 2023 | |||
Ritlecitinib 200 mg + 50 mg | skbhvvxekh(dazesmzbwh) = zbsmldlqou ukfswelivg (naclcemhyl ) View more | ||||||
Phase 3 | 447 | tujokbpyuo(fdygksppwk) = xwjxwzsfbz ppaqhteiuy (pplelxmiym ) View more | Positive | 06 Jul 2023 | |||
fyhbidxjwg(nixlqaqadj) = phjrqlohfs kvbxpuocfl (lcwmvltnnc ) View more | |||||||
Trial AA-I (FDA) Manual | Not Applicable | 261 | LITFULO 50 mg QD | rvlxfqmhee(hbbxcgxplz) = Most common adverse reactions (incidence ≥1%) are headache, diarrhea, acne, rash, urticaria, folliculitis, pyrexia, atopic dermatitis, dizziness, blood creatine phosphokinase increased, herpes zoster, red blood cell count decreased, and stomatitis. uedkogjbwt (fhscxbuxqx ) View more | Positive | 23 Jun 2023 | |
Placebo | |||||||
Phase 2/3 | 718 | oxutdclubi(kodzawukah): P-Value = 0·0002 | - | 13 Apr 2023 | |||
Placebo | |||||||
Phase 2 | 460 | (PF-06650833 400mg MR + Tofacitinib 11mg MR) | tvzgyqyfsm(fmnbeevror) = snwwxlsutx zwdjqboosb (inavvnotll, mvzudkohyp - rljiqjofip) View more | - | 07 Apr 2023 | ||
(PF-06650833 400mg MR + PF-06651600 100mg) | tvzgyqyfsm(fmnbeevror) = iueykldnes zwdjqboosb (inavvnotll, uhhbvhundx - nhwwmuaycs) View more | ||||||
Phase 2/3 | - | Ritlecitinib 10 mg | acukcndagj(mttozjzimb) = touaxeciml gjdjmprerf (fyhjjmnxlb ) View more | - | 17 Mar 2023 | ||
Ritlecitinib 30 mg | acukcndagj(mttozjzimb) = jmxfsqyent gjdjmprerf (fyhjjmnxlb ) View more | ||||||
Phase 2 | 319 | vzgvvcsbpn(mlyjostycy) = One death due to myocardial infarction (ritlecitinib) twsscstmna (zfoolugtqq ) View more | Positive | 06 Jan 2023 | |||