Last update 21 Nov 2024

Pemigatinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pemigatinib (JAN/USAN/INN)
+ [6]
Mechanism
FGFR1 antagonists(Fibroblast growth factor receptor 1 antagonists), FGFR2 antagonists(Fibroblast growth factor receptor 2 antagonists), FGFR3 antagonists(Fibroblast growth factor receptor 3 antagonists)
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
RegulationPriority Review (US), Conditional marketing approval (CN), Orphan Drug (EU), Breakthrough Therapy (US), Accelerated Approval (US)
Login to view timeline

Structure

Molecular FormulaC24H27F2N5O4
InChIKeyHCDMJFOHIXMBOV-UHFFFAOYSA-N
CAS Registry1513857-77-6

External Link

KEGGWikiATCDrug Bank
D11417Pemigatinib

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Advanced Bile Duct Carcinoma
KR
25 Apr 2023
Chromosome 8p11 myeloproliferative syndrome
US
26 Aug 2022
Bile Duct Neoplasms
CA
17 Sep 2021
Locally Advanced Cholangiocarcinoma
EU
26 Mar 2021
Locally Advanced Cholangiocarcinoma
NO
26 Mar 2021
Locally Advanced Cholangiocarcinoma
IS
26 Mar 2021
Locally Advanced Cholangiocarcinoma
LI
26 Mar 2021
Metastatic Cholangiocarcinoma
NO
26 Mar 2021
Metastatic Cholangiocarcinoma
IS
26 Mar 2021
Metastatic Cholangiocarcinoma
EU
26 Mar 2021
Metastatic Cholangiocarcinoma
LI
26 Mar 2021
FGFR2 fusion or rearranged Cholangiocarcinoma
JP
23 Mar 2021
FGFR2 positive Intrahepatic Cholangiocarcinoma
US
17 Apr 2020
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
Unresectable Intrahepatic CholangiocarcinomaPhase 3
NL
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
BE
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
GB
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
JP
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
AT
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
DK
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
DE
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
FI
03 Jun 2019
Unresectable Intrahepatic CholangiocarcinomaPhase 3
ES
03 Jun 2019
FGFR2 fusion or rearranged CholangiocarcinomaDiscovery
CN
12 Jul 2021
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
10
(Pemigatinib 6 mg Monotherapy)
jqexgpetem(bgwjbzqxcn) = rsbcibwias mlmxvlkhty (frumjmwrdo, lexcwnbpba - gbyhjvqxzt)
-
19 Sep 2024
(Pemigatinib 9 mg Monotherapy)
jqexgpetem(bgwjbzqxcn) = eijaucqyfu mlmxvlkhty (frumjmwrdo, cowtzxufpk - mmcnnwjchv)
Phase 2
8
lzojtirjzr(jjjxsetsiy) = ixvkypgyqp oibvhqokuc (wabhbvufvr, pktxytgizp - tevsbcdenq)
-
06 Aug 2024
Phase 2
47
Pemigatinib 13.5 mg
(nmqpxntzxh) = wewlvyrhrq hqzdjokkwk (qkpvhljtnh )
Positive
14 May 2024
Phase 2
Solid tumor
Second line
FGFR1-FGFR3 alterations
107
(fusions/rearrangements)
(qixunovxiw) = ncwtpgfrym uepdbsmgrl (vyarrpmtlz )
Positive
06 May 2024
(activating non-kinase domain mutations)
(qixunovxiw) = fywnjhkfdl uepdbsmgrl (vyarrpmtlz )
Phase 1
8
(Arm A (Ivosidenib, Cisplatin, Gemcitabine))
nkwvwqtbnr(hlxulmxtkc) = vguhkeiopo jpbxpsvmny (mpizdpmarb, esdptvwjga - jjhayubksl)
-
02 May 2024
(Arm B (Pemigatinib, Cisplatin, Gemcitabine))
(zcztfolfaj) = fvkqdwgwei pjsbauqqfy (qaicfymidi, hvcotosgkv - zrdoovmyey)
Phase 2
14
Quality-of-Life Assessment+Pemigatinib
russjcwckf(bmpuxjfrxv) = mntorsgcmk pcqjdyxzzg (agmnyoyklt, xpnaogbghy - gymyznzftl)
-
21 Feb 2024
Phase 2
260
Pemigatinib 13.5 mg once daily continuously
(FGFR3 mutations or fusions/rearrangements)
(djbrtbajcn) = gtjdlfpenv jabzpkouws (bbnbdonscd, 10.9 - 26.7)
Positive
01 Feb 2024
Pemigatinib 13.5 mg once daily intermittently
(FGFR3 mutations or fusions/rearrangements)
(djbrtbajcn) = qzozucyeye jabzpkouws (bbnbdonscd, 15.5 - 32.7)
Not Applicable
120
(xqbgnmxzjt) = zwglczaiko ilxbhzdans (ykvayuuyaw, 6.4 - 8.6)
Positive
18 Jan 2024
Phase 2
107
(drfrbejcbe) = dkbjybnhnx ujlmudumam (mpxehtsybb )
Positive
14 Apr 2023
(drfrbejcbe) = rgcrgozavt ujlmudumam (mpxehtsybb )
Phase 2
30
(hruymkadwy) = eouqeznjrm hivyihevwc (xnklgoxind, 15.2 - NC)
Positive
14 Apr 2023
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
Chat with Hiro
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free