A Randomized, Double-Blind, Active-Controlled, 4-week Parallel GroupStudy to Evaluate the Efficacy and Safety of Lactitol and Probiotic Bacillus Coagulans SC208 in patients with Chronic Idiopathic Constipation. - Lactiliq-TM Syrup

Start Date31 Oct 2022

Sponsor / Collaborator

Synergia Life Sciences Pvt Ltd.

[+1]

CTRI/2015/02/005580 / RecruitingPhase 3

A Prospective, Randomised, Double-Blind, Placebo-Controlled, 4 week Parallel Group Study to Evaluate the Efficacy and Safety of Lactitol and Psyllium Alone and in Combination in Treatment of Constipation

Start Date16 Mar 2015

Sponsor / Collaborator

Danisco Sweeteners Oy

NCT02307383 / Unknown statusPhase 2IIT

Pilot Study of the Effectiveness of Probiotics and Lactitol for the Intestinal Decolonization of People Carriers of Klebsiella Pneumoniae Producers of Carbapenemase OXA-48-type: DesProbiOXA Study

The combination of Lactitol and Probiotics (Lactobacillus acidophilus and Lactobacillus Biphidus) administered orally is an effective strategy of intestinal decolonization of Enterobacter produced OXA-48-type carbapenemase.
The purpose of this study is to determine the effectiveness of Lactitol and Probiotics for the intestinal decolonization of people who carried Klebsiella pneumoniae produced OXA-48-type Carbapenemase.

Start Date01 Oct 2014

Sponsor / Collaborator-

100 Clinical Results associated with Lactitol

100 Translational Medicine associated with Lactitol

100 Patents (Medical) associated with Lactitol

265

Literatures (Medical) associated with Lactitol

30 Aug 2024·Journal of the science of food and agriculture

In vitro and in vivo digestibility of prebiotic galactooligosacharides synthesized by β‐galactosidase from Lactobacillus delbruecki subsp. bulgaricusCRL450

Article

Author: Hernández Hernández, Oswaldo ; Zárate, Gabriela ; Palacios, Jorge ; Fara, Agustina ; Montilla, Antonia

Abstract:

BACKGROUND:

The general assumption that prebiotics reach the colon without any alterations has been challenged. Some in vitro and in vivo studies have demonstrated that ‘non‐digestible’ oligosaccharides are digested to different degrees depending on their structural composition. In the present study, we compared different methods aiming to assess the digestibility of oligosaccharides synthesized by β‐galactosidase (β‐gal) of Lactobacillus delbruecki subsp. bulgaricus CRL450 (CRL450‐β‐gal) from lactose, lactulose and lactitol.

RESULTS:

In the simulated gastrointestinal fluid method, no changes were observed. However, the oligosaccharides synthesized by CRL450‐β‐gal were partially hydrolyzed in vitro, depending on their structure and composition, with rat small intestinal extract (RSIE) and small intestinal brush‐border membrane vesicles (BBMV) from pig. Digestion of some oligosaccharides increased when mixtures were fed to C57BL/6 mice used as in vivo model; however, lactulose‐oligosaccharides were the most resistant to the physiological conditions of mice. In general β (1→6) linked products showed higher resistance compared to β (1→3) oligosaccharides.

CONCLUSION:

In vitro digestion methods, without disaccharidases, may underestimate the importance of carbohydrates hydrolysis in the small intestine. Although BVMM and RSIE digestion assays are appropriate in vitro methods for these studies, in vivo studies remain the most reliable for understanding what actually happens in the digestion of oligosaccharides. © 2024 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

02 Oct 2023·Journal of environmental science and health. Part C, Toxicology and carcinogenesis

Determination of the genotoxic effects of sweeteners, mannitol and lactitol

Article

Author: Avuloglu-Yilmaz, Ece ; Eker-Kartal, Ebru

The changes in dietary habit around the world have led to an increased use of additives in the food. The safety of food additives has been a main focus of research for many years due to the ongoing debate on their potential effects on health. In this study, the in vitro genotoxic effects of mannitol and lactitol, polyols used as sweetener food additives, were evaluated using chromosomal aberrations (CAs) and micronucleus (MN) assays in human peripheral lymphocytes. Additionally, the effects of these sweeteners on the mitotic index (MI) and nuclear division index (NDI) were investigated. Concentrations of 500, 1000, 2000, 4000, and 8000 μg/mL for mannitol and 250, 500, 1000, 2000, and 4000 μg/mL for lactitol were used. The results indicated that both polyols did not affect CA and MN frequency, and did not cause a significant change in NDI at all treatment concentratoins. However, mannitol (except at concentrations of 500 and 1000 μg/mL) and lactitol (except at 250 μg/mL) significantly decreased the MI compared to the control at almost all concentrations and treatment times. In conclusion, it was observed that mannitol and lactitol did not have a significant genotoxic effect at the concentrations used in human lymphocytes in vitro.

22 Sep 2023·Medicine

Primary prevention of hepatic encephalopathy post-TIPS: A systematic review and meta-analysis

Review

Author: Liang, Aileen ; Khan, Mohammad Qasim ; Brar, Sukhman ; Teriaky, Anouar ; Almaghrabi, Majed ; Qumosani, Karim

Background::

Transjugular intrahepatic portosystemic shunt (TIPS) can be an effective treatment for cirrhotic patients who develop variceal bleeding and ascites. However, TIPS placement is associated with an increased risk of developing hepatic encephalopathy (HE). Recently, there have been efforts to use the typical medical therapies prophylactically in patients undergoing TIPS placement to prevent post-TIPS HE.

Methods::

We conducted literature searches in MEDLINE, Embase, CINAHL, Scopus, and Cochrane to examine studies that use prophylactic medical therapy for preventing post-TIPS HE. A narrative synthesis and grading of recommendations assessment assessment were done for all studies. Meta-analysis was performed for eligible studies using the Mantel-Haenszel method random-effects model. Nine hundred twenty-one articles were screened and 5 studies were included in the study after 2 levels of screening. The medications studied were rifaximin, lactulose, lactitol, L-Ornithine-L-aspartate (LOLA), albumin, and combination therapies.

Results::

Narrative results showed that lactulose, lactitol, LOLA and albumin prophylaxis were not associated with reduction in HE occurrence or mortality. A combination of rifaximin and lactulose was found to be associated with lower occurrence of HE, and the results were not different when LOLA was added. Meta-analysis (n = 3) showed that rifaximin treatment was not associated with changes in HE occurrences.

Conclusion::

In conclusion, a vast majority of medications were not found to be effective post-TIPS HE prophylaxis when used alone. A rifaximin and lactulose combination therapy may be beneficial. Overall, there is significant limitation in the current data and more studies are needed to yield more robust meta-analysis results in the future.

News (Medical) associated with Lactitol

24 Jan 2018

·www.bioportfolio.com

Global and Chinese Lactitol Industry, 2018 Market Research Report [Report Updated: 22012018] Prices from USD $3000

The 'Global and Chinese Lactitol Industry, 20132023 Market Research Report' is a professional and indepth study on the current state of the global Lactitol industry with a focus on the Chinese market. The report provides key statistics on the market status of the Lactitol manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 20132018 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Lactitol industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates 20182023 market development trends of Lactitol industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out. In the end, the report makes some important proposals for a new project of Lactitol Industry before evaluating its feasibility. Overall, the report provides an indepth insight of 20132023 global and Chinese Lactitol industry covering all important parameters. Any special requirements about this report, please let us know and we can provide custom report.

100 Deals associated with Lactitol

External Link

KEGG	Wiki	ATC	Drug Bank
D08266	Lactitol	A06AD12	DB12942

R&D Status

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Indication	Country/Location	Organization	Date
Chronic idiopathic constipation	US	Braintree Laboratories, Inc.	12 Feb 2020
Constipation	-	-	01 Jan 1985
Liver Diseases	-	-	01 Jan 1985

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