Delving into the Latest Updates on Lactitol with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Lactitol (NF/INN), Lactitol Hydrate

+ [9]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System DisordersOther Diseases

Active Indication

Chronic idiopathic constipationDecompensated cirrhosis of liverHyperammonemia+ [2]

Inactive Indication-

Originator Organization-

Active Organization

Braintree Laboratories, Inc.

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date

(01 Jan 1985),

ConstipationLiver Diseases

Regulation-

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Structure/Sequence

Molecular FormulaC12H24O11

InChIKeyVQHSOMBJVWLPSR-JVCRWLNRSA-N

CAS Registry585-86-4

Pomegranate seeds, a by-product of pomegranate processing, are gaining attention in food industries due to their high antioxidant activity. However, the lack of quality markers reflecting activity and spatial characteristics limits their utilization and product stability. In this research, a selective and sensitive method integrating ultra performance liquid chromatography-quadrupole time-of-flight mass spectrometry with feature-based molecular networking, and desorption electrospray ionization-mass spectrometry imaging developed to identify components and locate in-situ images of quality markers via spatial metabolomics analysis. Additionally, molecular docking analyses and 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assays validated the antioxidant quality markers and elucidated correlations between these markers, regions, and activity. A total of 227 components were identified, and six were selected as quality markers for pomegranate seeds, reflecting their antioxidant activity and spatial characteristics. Consequently, this research provides an efficient method for screening food quality markers based on activity and spatial characteristics, providing insights into food quality evaluation.

07 Feb 2025·ACS Catalysis

Photothermal Conversion of Biopolyols and Sugars into Syngas over Pd–PdO/TiO₂

Author: Zhou, Hongru ; Luo, Jincheng ; Yang, Jingxuan ; Wang, Min

Photocatalysis is promising for reforming biopolyols and sugars into syngas (CO+H₂), while the carbon is easily overoxidized to CO₂ due to the hydroxyl radical (•OH) under aqueous conditions.Targeting this problem, a temperature-controlled photo-reforming strategy is proposed and the Pd-PdO/TiO₂ is used as the catalyst.The photocatalytic reforming process effectively breaks the C-H and C-C bonds of biomass to produce radicals.The increased reaction temperature not only increases the photocatalytic reaction rate but also thermodynamically fine-tunes the radical reaction process, facilitating the decarbonylation of acyl radical intermediates and prohibiting its overoxidn. to CO₂.With the reaction temperature increased from 40 to 180 °C, the CO selectivity from glycerol reforming over Pd-PdO/TiO₂ catalyst under aqueous conditions improves significantly from 1.6% to 66%.The unique Pd-PdO/TiO₂ structure plays an important role in syngas productionOn one hand, the decorated Pd species significantly promote light adsorption and the separation of photogenerated charge carriers.On the other hand, the PdO nanoparticles effectively facilitate the adsorption and decarbonylation process of acyl radical intermediates.A CO yield of over 60% for glycerol reforming under photothermal conditions can be obtained over Pd-PdO/TiO₂, which is 3 times that of pristine TiO₂ (20%).A wide range of biopolyols and sugars can also be converted into syngas through this photothermal system with a CO yield of 20-66%, along with 0.17-2.13 mmol·g^-1·h^-1 H₂ evolution.

01 Jan 2025·Applied Biochemistry and Biotechnology

Application and Cytotoxicity Evaluation of Fe-MIL-101 Nanozyme in Milk

Article

Author: Tu, Jia ; Cheng, Yunhui ; Xu, Liguang ; Chen, Wei ; Xing, Keyu ; Tang, Ruicong ; Xu, Zhou ; Wang, Xufeng

In this study, we used Fe-MIL-101 nanozyme to convert lactose into lactitol, and it was proved that Fe-MIL-101 nanozyme has lactase-like activity. Due to the potential health effects of nanomaterials, we evaluated the cytotoxicity of Fe-MIL-101 nanozyme. To reduce the potential toxicity of the nanozyme, we applied centrifugation and membrane filtration. When the membrane aperture size was 100 nm, the residual content of Fe-MIL-101 nanozyme was 14.09 μg/mL. The residual content of Fe-MIL-101 nanozyme was reduced by optimizing time, temperature, and Fe-MIL-101 nanozyme-to-substrate ratio. It was showed that the concentration of Fe was 38.47 mg/kg and the concentration of H₂BDC was 0 mg/kg under optimized conditions (110℃, 2 h of reaction and the ratio of Fe-MIL-101 nanozyme to substrate is 1:20). The result met the national standard of China. Experiments measuring cytotoxicity, oxidative stress, and cell membrane damage revealed that less than 20 μg/mL Fe-MIL-101 nanozyme had no significant cytotoxicity. Our study findings showed that Fe-MIL-101 nanozyme reduced lactose content in milk.

1

News (Medical) associated with Lactitol

24 Jan 2018

·www.bioportfolio.com

Global and Chinese Lactitol Industry, 2018 Market Research Report [Report Updated: 22012018] Prices from USD $3000

The 'Global and Chinese Lactitol Industry, 20132023 Market Research Report' is a professional and indepth study on the current state of the global Lactitol industry with a focus on the Chinese market. The report provides key statistics on the market status of the Lactitol manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail. In this part, the report presents the company profile, product specifications, capacity, production value, and 20132018 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Lactitol industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates 20182023 market development trends of Lactitol industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out. In the end, the report makes some important proposals for a new project of Lactitol Industry before evaluating its feasibility. Overall, the report provides an indepth insight of 20132023 global and Chinese Lactitol industry covering all important parameters. Any special requirements about this report, please let us know and we can provide custom report.

100 Deals associated with Lactitol

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External Link

KEGG	Wiki	ATC	Drug Bank
D08266	Lactitol	A06AD12	DB12942

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Chronic idiopathic constipation	United States	Braintree Laboratories, Inc.	12 Feb 2020
Decompensated cirrhosis of liver	Japan	Braintree Laboratories, Inc.	30 Sep 1998
Hyperammonemia	Japan	Braintree Laboratories, Inc.	30 Sep 1998
Constipation	-	-	01 Jan 1985
Liver Diseases	-	-	01 Jan 1985