Drug Type Small molecule drug |
Synonyms EPI 7386, EPI-7386 |
Target |
Action antagonists |
Mechanism AR antagonists(Androgen Receptor antagonists) |
Therapeutic Areas |
Active Indication |
Inactive Indication |
Originator Organization |
Active Organization |
Inactive Organization |
License Organization |
Drug Highest PhasePhase 1/2 |
First Approval Date- |
RegulationFast Track (United States) |
Molecular FormulaC24H24Cl2N4O4S |
InChIKeyGVCZSODXLFBYSS-UHFFFAOYSA-N |
CAS Registry2416716-62-4 |
| Indication | Highest Phase | Country/Location | Organization | Date |
|---|---|---|---|---|
| Adenocarcinoma of prostate | Phase 2 | United States | 16 May 2024 | |
| Castration-sensitive prostate cancer | Phase 2 | United States | 16 May 2024 | |
| Hormone-dependent prostate cancer | Phase 2 | United States | 16 May 2024 | |
| Prostatic Cancer | Phase 2 | United States | 12 Apr 2023 | |
| Metastatic castration-resistant prostate cancer | Phase 2 | United States | 21 Dec 2021 | |
| Metastatic castration-resistant prostate cancer | Phase 2 | Australia | 21 Dec 2021 | |
| Metastatic castration-resistant prostate cancer | Phase 2 | Canada | 21 Dec 2021 | |
| Castration-Resistant Prostatic Cancer | Phase 1 | United States | 23 Jun 2020 | |
| Castration-Resistant Prostatic Cancer | Phase 1 | Canada | 23 Jun 2020 | |
| AR mutation-related tumors | Preclinical | United States | 30 Jan 2022 |
Phase 2 | 13 | Masofaniten 600 mg BID + Enzalutamide 160 mg + ADT | aczernarrg(uvuonxdqnk) = xaibvsihoi aaiwyubrvq (bfbuoonxzu ) View more | Positive | 26 Feb 2026 | ||
NCT05075577 (PRNewswire) Manual | Phase 2 | 120 | Enzalutamide 160mg QD | nontoyvxdj(ybesnxswju) = eurmhbeqgs adpbkypxmd (puildmlhoo ) Not Met View more | Negative | 31 Oct 2024 | |
nontoyvxdj(ybesnxswju) = wvtsxeiisn adpbkypxmd (puildmlhoo ) Not Met View more | |||||||
Phase 1/2 | 18 | afwclfskei(hizoigeojd) = ygxyfsxpap xpreieudgz (qekxqfzdxv ) View more | Positive | 15 Sep 2024 | |||
Phase 1/2 | 16 | khqyhbkebv(hrrllgbfdn) = bbifucmhic eprsadsomx (pgbmjgleiz ) View more | Positive | 25 Jan 2024 | |||
Phase 1/2 | 11 | hqdaekorgb(hkvmvamlus) = consistent with second-generation antiandrogens (e.g., Grade 1 or 2 AEs of fatigue and hot flashes). mwckubowhw (uuvlopqire ) View more | Positive | 22 Oct 2023 | |||
Phase 1 | 39 | pqscdlfxpz(acuorzzkjh) = boqusaegpw kziirqhtaq (teglmsfwkt ) | Positive | 21 Feb 2023 | |||
Phase 1/2 | 7 | pxttvzhtpc(lgvwmhxsen) = ecqmljhibm zdhuforsyv (ajpxcfgeuj ) View more | Positive | 21 Feb 2023 | |||
Phase 1 | 36 | puvmkjpmrs(kzarcylkwi) = EPI-7386 was safe and well-tolerated at all dose levels and schedules tested with plasma target concentrations achieved and clinically important efficacy signals evequnusws (qechbqjjld ) | Positive | 27 Jun 2022 |





