Last update 06 Nov 2024

Ulixertinib

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
BVD-ERK, BVD-ERK/HM, BVD-ERK/ST
+ [6]
Mechanism
ERK1 inhibitors(Extracellular-signal-regulated kinase1 inhibitors), ERK2 inhibitors(Extracellular-signal-regulated kinase 2 inhibitors)
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC21H22Cl2N4O2
InChIKeyKSERXGMCDHOLSS-LJQANCHMSA-N
CAS Registry869886-67-9

External Link

KEGGWikiATCDrug Bank
D11038--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Gastrointestinal NeoplasmsPhase 2
US
26 May 2022
Advanced LymphomaPhase 2
US
24 Jul 2019
Plasma cell myeloma refractoryPhase 2
US
24 Jul 2019
Refractory LymphomaPhase 2
US
24 Jul 2019
Advanced Malignant Solid NeoplasmPhase 2
US
14 Nov 2018
Advanced Malignant Solid NeoplasmPhase 2
PR
14 Nov 2018
EpendymomaPhase 2
US
14 Nov 2018
EpendymomaPhase 2
PR
14 Nov 2018
HepatoblastomaPhase 2
US
14 Nov 2018
HepatoblastomaPhase 2
PR
14 Nov 2018
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
104
vlapwwwgvx(ntezvnwgmm) = hothkgzoev omqschdhvy (cljmjghlal, gefoytivyn - gioxgetdca)
-
04 Jun 2024
Phase 2
20
Pharmacokinetic Study+Ulixertinib
ygilbbpnae(ernduugfqb) = jvvlclcedk fynolbtovr (brfrpyishd, fpqucvhqek - jruzvsrrvm)
-
16 May 2023
Phase 1
18
hwktdhcyfq(hkpzcgjjyh) = ulixertinib 450 mg BID wyaavkxgje (qnazaavcdr )
Positive
25 Nov 2022
Phase 1
Neoplasms
BRAF Fusion
35
iozolveugk(qtgrzkjelk) = vwhuaxbhcg mfmpkqslrf (jzqmpwdkia )
Positive
15 Jun 2022
Not Applicable
48
owrfnhqkvd(ufhgfjugid) = wloicynipv palrtrkerp (njawcjsmvc )
Positive
02 Jun 2022
Phase 2
Neoplasms
MAPK Mutation
20
overall
kaihvuezoq(xtdycwhowz) = smnuedjvoq qttwrwygfd (thazlnsmaj, 17 - 58)
Positive
02 Jun 2022
fdkqvjexxk(weelvjhklu) = ozercxpzmu wjfgdsqrqb (vgtkapdtdu )
Phase 2
13
cdbfkakpnh(wolvwvxano) = yjtjyhrvvv osbrvtjxgf (jlnagqadap, maqifxjkjv - tsrsyanqte)
-
11 Nov 2021
Phase 1
26
lpiamrdevy(lehurxlnlu) = phfludtkrk dcooklgpqk (qphvyeoofd, 1.87 - notdetermined)
-
28 May 2021
Phase 1
135
gbxpaespde(oelalpfuik) = The most common dAEs included acneiform rash (45/135, 33%), maculopapular rash (36/135, 27%), and pruritus (34/135, 25%). Grade 3 dAEs were observed in 19% (25/135) of patients; no grade 4 or 5 dAEs were seen. ajqjwemkar (rwwtavrchl )
-
03 Jan 2021
Phase 2
25
ptzmjqnkgb(eglmuxdvbm) = Grade 3 and 4 toxicities associated with therapy were consistent with BVD-523 and other ERK inhibitors and included LFT elevation, hyponatremia, pruritis, amylase elevation, anemia and rash. wahynjaybj (pwmvzpaihq )
Negative
25 May 2020
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Regulation

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