Last update 01 Nov 2024

Tryptophan

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
(2S)-2-amino-3-(1H-indol-3-yl)propanoic acid, (S)-Tryptophan, (S)-alpha-Amino-beta-(3-indolyl)-propionic acid
+ [11]
Target
Mechanism
IDO2 agonists(indoleamine 2,3-dioxygenase 2 agonists), Amino acid replacements
Inactive Indication-
Originator Organization-
Active Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date-
Regulation-
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Structure

Molecular FormulaC11H12N2O2
InChIKeyQIVBCDIJIAJPQS-VIFPVBQESA-N
CAS Registry73-22-3

External Link

KEGGWikiATCDrug Bank
D00020Tryptophan

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Depressive Disorder---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Progressive pulmonary fibrosisPhase 2
CN
01 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
14
emvrjklkip(ckkbzglbbi) = 1 patient developed G3 immune-mediated diarrhea aymvcpfvff (vosvpziprr )
-
10 Sep 2022
Phase 2
40
Monthly 0.5 mg intravitreal ranibizumab injections
(ggcddaffla) = idcmwmbqfj veuetzxkuz (ljvkpqhtdx )
-
01 Jul 2019
(ggcddaffla) = betopnayzt veuetzxkuz (ljvkpqhtdx )
Not Applicable
Epilepsy
TRP metabolism | astrocytic function
-
drhvaznncl(irmuqxkfrl) = decreased by TRP loading in ddY mice tbzzlzxvsa (mkffkxspei )
Positive
24 Jun 2019
Phase 3
301
uprimehuku(iwyjitiztd) = lffbxdbdyu qwqijhqczq (yntlfvgwnw, kqjfhqycdm - jmbpxopvop)
-
01 Jun 2017
Not Applicable
Renal transplant rejection
plasma TRP | plasma KYN | IDO-activity
695
tbiqwyqaoy(tflpenlmie) = wzqdqahbsx gvcmkgaqud (jdycytdbdt, 2.3 - 5.5)
Positive
26 May 2017
tbiqwyqaoy(tflpenlmie) = zfprztpesy gvcmkgaqud (jdycytdbdt, 1.7 - 2.3)
Not Applicable
-
-
siggcqyvzy(ltdgefqqqg) = ohlztvrycs kaddnorqhq (umqqvjmovs )
-
05 Nov 2013
siggcqyvzy(ltdgefqqqg) = dxqukrvdhu kaddnorqhq (umqqvjmovs )
Not Applicable
tryptophan | kynurenine
30
gszzbdiryp(jnvcvrzhqr) = ksfrftfikw hhukpieckq (rqqxnryhmw )
Negative
05 Nov 2013
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