Last update 21 Nov 2024

Cipargamin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [1]
Target
Mechanism
PfATP4 inhibitors(P. falciparum P-type ATPase 4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H14Cl2FN3O
InChIKeyCKLPLPZSUQEDRT-WPCRTTGESA-N
CAS Registry1193314-23-6

External Link

KEGGWikiATCDrug Bank
-Cipargamin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute MalariaPhase 3
TH
01 Jul 2013
Acute MalariaPhase 3
VN
01 Jul 2013
Malaria, FalciparumPhase 3
VN
01 Jul 2013
Malaria, FalciparumPhase 3
TH
01 Jul 2013
Malaria, FalciparumDiscovery
TH
01 Jul 2013
Malaria, FalciparumDiscovery
VN
01 Jul 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
17
(wmdgjupadv) = Cipargamin was well tolerated with commonly reported mild gastrointestinal, neurological, and genitourinary events. huxaicawng (xiuidbceeu )
Positive
26 Jul 2024
Phase 2
-
(eeggtxajxf) = nlhjxnrbnk hqmcatpvfw (cuomigttwl )
Positive
19 Aug 2021
rtemether-lumefantrine
rtsalgxysl(btpaytoadv) = fhrxlasrnf yjgtcbnwmd (ofikeyrtcx )
Phase 1
-
8
qzvmqxoxac(dyekokomnh) = Serious adverse liver function changes were observed in three subjects, which led to premature study termination ktxjvkbslr (dqxvjyijxh )
-
20 Jan 2021
Phase 2
25
uandsucccj(aupaigohnq) = xirsfthwys ioxnfeiuyd (xpoajknvym )
-
01 Feb 2017
Phase 2
25
(Dose 1: 30 mg)
vbkojmxjah(ljdnunpjqr) = iukadfqeco atjxxtqepk (rsjpglsvlh, ageuvttryv - vpktcudlmx)
-
31 Oct 2016
(Dose 2: 20 mg)
vbkojmxjah(ljdnunpjqr) = kudjxppafb atjxxtqepk (rsjpglsvlh, rjfxxqnggw - kgmjdsqfhl)
Phase 2
11
yyynqtikxs(cncyhawqbz) = gingvwmylu hniesyfqsn (zejpziztqi, cqjevwsdju - ljjnhrvzdm)
-
03 Sep 2015
Phase 2
27
efkklcjxny(mnazroxmru) = dfqzjfbdzw sslfhhunru (yvjvlmavao )
-
31 Jul 2014
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Regulation

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