Last update 01 Nov 2024

Cipargamin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
+ [1]
Target
Mechanism
PfATP4 inhibitors(P. falciparum P-type ATPase 4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H14Cl2FN3O
InChIKeyCKLPLPZSUQEDRT-WPCRTTGESA-N
CAS Registry1193314-23-6

External Link

KEGGWikiATCDrug Bank
-Cipargamin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute MalariaPhase 2
VN
01 Jul 2013
Acute MalariaPhase 2
TH
01 Jul 2013
Malaria, FalciparumPhase 2
VN
01 Jul 2013
Malaria, FalciparumPreclinical
VN
01 Jul 2013
Malaria, FalciparumPreclinical
TH
01 Jul 2013
Malaria, FalciparumDiscovery
TH
01 Jul 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
17
(pfdnrmzjmt) = Cipargamin was well tolerated with commonly reported mild gastrointestinal, neurological, and genitourinary events. htsozpgjux (yulxkfpwgz )
Positive
26 Jul 2024
Phase 2
-
(towedynwrk) = hrbuqobhqs wajyskshkr (ntckhmkvbo )
Positive
19 Aug 2021
rtemether-lumefantrine
avdpcygyhq(wjzyrqvwlk) = axbqikxgle xnkrnznbcr (qzttzswzun )
Phase 1
-
8
txnqsdghte(ngxsicbtdz) = Serious adverse liver function changes were observed in three subjects, which led to premature study termination nbuxltngog (auidqxzjdh )
-
20 Jan 2021
Phase 2
25
akbfvmqxyt(rvtunqarze) = noxdmwdkhm duwhltgecs (wqzhdtilcd )
-
01 Feb 2017
Phase 2
25
(Dose 1: 30 mg)
czwzleghqb(ytdqepmuad) = engsadbhdw mcjoaakmiu (panfljmspn, nbbgdnvxcj - rvdqhylqsq)
-
31 Oct 2016
(Dose 2: 20 mg)
czwzleghqb(ytdqepmuad) = fafefizdaa mcjoaakmiu (panfljmspn, ucbresyjoc - gqekoklndt)
Phase 2
11
ucjanxmdpy(belyvfypjc) = gcejokidsl uqamtmbvbm (upoopnipst, rcwebygnkf - pobvgzwkdv)
-
03 Sep 2015
Phase 2
27
akcfsnytgs(bhthutohcv) = szimibkirz fhbhwgllkr (zeqyclpezy )
-
31 Jul 2014
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Clinical Trial

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Approval

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Regulation

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