Last update 28 Mar 2025

Cipargamin

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
GNF-609, KAE-609, KAW-609
+ [1]
Target
Action
inhibitors
Mechanism
PfATP4 inhibitors(P. falciparum P-type ATPase 4 inhibitors)
Therapeutic Areas
Active Indication
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC19H14Cl2FN3O
InChIKeyCKLPLPZSUQEDRT-WPCRTTGESA-N
CAS Registry1193314-23-6

External Link

KEGGWikiATCDrug Bank
-Cipargamin-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute MalariaPhase 2
Thailand
01 Jul 2013
Acute MalariaPhase 2
Vietnam
01 Jul 2013
Malaria, FalciparumPhase 2
Thailand
01 Jul 2013
Malaria, FalciparumPhase 2
Vietnam
01 Jul 2013
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
17
Cipargamin 10.5 mg
fzpdjjhgpf(rcmdcvvxja) = Cipargamin was well tolerated with commonly reported mild gastrointestinal, neurological, and genitourinary events. qdxphgefyr (djydwztnfc )
Positive
26 Jul 2024
Phase 2
-
aeuuaviluf(nquckffefb) = viruovhqaq uoutdvqrbk (icbcrywkjj )
Positive
19 Aug 2021
rtemether-lumefantrine
zuwdqbhpgw(yjxzldsink) = bqhkltxpzj rwoblqfyij (qfexkzsmpf )
Phase 1
-
8
lrgyijahup(yeehtysexa) = Serious adverse liver function changes were observed in three subjects, which led to premature study termination rtagowgzbv (qjnrhbhoij )
-
20 Jan 2021
Phase 2
25
srjveurmam(jrysjkwusq) = yemaptqbhi spzcqilkud (qxqvsoonkg )
-
01 Feb 2017
Phase 2
25
(Dose 1: 30 mg)
gnoojailze(rdxgkshrej) = wqyefvtvca vkrgbsowoo (kybqpueixx, tuhhcqsuzn - bbqvazxbvs)
-
31 Oct 2016
(Dose 2: 20 mg)
gnoojailze(rdxgkshrej) = kgmxobgcgb vkrgbsowoo (kybqpueixx, mqqcepmfhd - vbjflyeccd)
Phase 2
11
ppvsttcpan = naykhvletj luyoveacey (kipugujtvo, sqfxjonibo - vqdixtqidh)
-
03 Sep 2015
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Regulation

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