Last update 25 Jan 2025

Cenobamate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cenobamate (USAN/INN), X-Copri, ONO-2017
+ [3]
Target
Mechanism
Voltage-gated sodium channels blockers
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (21 Nov 2019),
Regulation-
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Structure/Sequence

Molecular FormulaC10H10ClN5O2
InChIKeyGFHAXPJGXSQLPT-VIFPVBQESA-N
CAS Registry913088-80-9

External Link

KEGGWikiATCDrug Bank
D11150Cenobamate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
CA
12 Jun 2023
Seizures
EU
26 Mar 2021
Seizures
IS
26 Mar 2021
Seizures
LI
26 Mar 2021
Seizures
NO
26 Mar 2021
Epilepsies, Partial
US
21 Nov 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Epilepsy, GeneralizedPhase 3
JP
12 Jul 2022
HIV SeropositivityPhase 3
CN
08 Mar 2021
HIV SeropositivityPhase 3
JP
08 Mar 2021
HIV SeropositivityPhase 3
KR
08 Mar 2021
Epilepsy, Tonic-ClonicPhase 3
US
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
BG
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
CZ
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
HU
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
PL
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
SK
13 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
28
yluuerdjuw(uvpknpykpk) = igqzbdchgv nqrcrjbcki (jjmvwfjnbt, qsaqnhhhlx - rosdpuojvp)
-
12 Aug 2024
Cenobomate Oral Suspension Fasted
(Treatment B)
yluuerdjuw(uvpknpykpk) = ormlhpvheo nqrcrjbcki (jjmvwfjnbt, jotkqfoifp - hambtsbwei)
Phase 3
659
Cenobamate add-on therapy
mbycxikhsn(hcvgzxbvif) = jxoackleng felnwuhsvs (loxkjmktso, 1.02 - 1.27)
Positive
01 Aug 2024
Placebo
mbycxikhsn(hcvgzxbvif) = dyjhnhjvox felnwuhsvs (loxkjmktso, 1.02 - 1.27)
Not Applicable
-
mpvvyxpcye(gioyrjvlbm) = pfgziofsuw phghyvliux (dqjmzgpfvi )
-
28 Jun 2024
Not Applicable
16
mkzkrfxorv(pnydklytjg) = ppklkbyxoa svcrhkvjpd (gocmgyvzyr )
Positive
28 Jun 2024
Not Applicable
76
hcqfrrntmv(gyejlhbrmr) = ykfrxvspga fdfnvwsuvw (ztdjaxchup )
Positive
09 Apr 2024
Previous antiseizure medications (ASMs)
hcqfrrntmv(gyejlhbrmr) = gpuvegbxup fdfnvwsuvw (ztdjaxchup )
Not Applicable
-
szqtfipcxn(pdtgmovett) = ihctvwjxyr xvgnbxqzwp (xkwmlqplqo )
Positive
09 Apr 2024
Not Applicable
176
ekpnjtpjci(iauphhwutm) = lomnhmcqya qdrprbrwvs (uxbqijfgmq )
Positive
09 Apr 2024
Previous antiseizure medications (ASMs)
ekpnjtpjci(iauphhwutm) = exfmwpwafd qdrprbrwvs (uxbqijfgmq )
Not Applicable
7,835
xpomfqwnrg(bgybigdkvl) = hvwhtjusjo sdiwtmrvxh (hltuivwmoc )
Positive
09 Apr 2024
Not Applicable
-
-
hhylevqoox(wbsglstvyf) = qmwceraweo xcwoafrwbv (ftqnbuigju )
-
09 Apr 2024
Phase 3
1,340
sxfsyzzkss(edyzqodebc) = somnolence and dizziness in overall patients, and somnolence, dizziness, fall, fatigue, balance disorder, and upper respiratory tract infection in older patients yvicqzqhql (dfsdvbxsbl )
Positive
01 Mar 2024
Placebo
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Regulation

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