Last update 06 Sep 2024

Cenobamate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Cenobamate (USAN/INN), X-Copri, ONO-2017
+ [3]
Mechanism
Voltage-gated sodium channels blockers
Inactive Indication
Originator Organization
Inactive Organization-
Drug Highest PhaseApproved
First Approval Date
US (21 Nov 2019),
Regulation-
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Structure

Molecular FormulaC10H10ClN5O2
InChIKeyGFHAXPJGXSQLPT-VIFPVBQESA-N
CAS Registry913088-80-9

External Link

KEGGWikiATCDrug Bank
D11150Cenobamate

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Epilepsy
EU
26 Mar 2021
Epilepsy
IS
26 Mar 2021
Epilepsy
LI
26 Mar 2021
Epilepsy
NO
26 Mar 2021
Seizures
EU
26 Mar 2021
Seizures
IS
26 Mar 2021
Seizures
LI
26 Mar 2021
Seizures
NO
26 Mar 2021
Epilepsies, Partial
US
21 Nov 2019
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Epilepsy, GeneralizedPhase 3
JP
12 Jul 2022
HIV SeropositivityPhase 3
CN
08 Mar 2021
HIV SeropositivityPhase 3
JP
08 Mar 2021
HIV SeropositivityPhase 3
KR
08 Mar 2021
Epilepsy, Tonic-ClonicPhase 3
US
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
BG
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
CZ
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
HU
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
PL
13 Aug 2019
Epilepsy, Tonic-ClonicPhase 3
SK
13 Aug 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
-
28
falcrdrekm(jxsjgydleq) = jmihbvqypq qikbiotuee (fchvnnncgr, firfdqcugz - xkxzflppra)
-
12 Aug 2024
Cenobomate Oral Suspension Fasted
(Treatment B)
falcrdrekm(jxsjgydleq) = dvqzedriwu qikbiotuee (fchvnnncgr, wydsrzdtvd - jveefhfkdv)
Phase 3
659
Cenobamate add-on therapy
vhiqvpjkvx(unyzjsmzqu) = cjmrygsfxp tfaqdsemoo (nwnznjrldf, 1.02 - 1.27)
Positive
01 Aug 2024
Placebo
vhiqvpjkvx(unyzjsmzqu) = msmerqbdgf tfaqdsemoo (nwnznjrldf, 1.02 - 1.27)
Not Applicable
-
354
kznmqunegh(lxtongtfhj) = cexnxtimks rjnhrfydme (khevuyknty )
Positive
04 Sep 2023
Phase 2
206
ytltqvquoz(mcatdgpxja) = xqjovyjanp exjkjhmuma (gmdnswrrhr )
Positive
04 Sep 2023
Placebo
ytltqvquoz(mcatdgpxja) = kegxebepmq exjkjhmuma (gmdnswrrhr )
Not Applicable
Epilepsies, Myoclonic
Add-on
pathogenic variants in the α subunit of the voltage-gated sodium channel gene SCN1A
4
mbdwannfsc(rfsilyfysn) = No severe adverse events occurred baziflavto (prdmmvsvjf )
Positive
04 Sep 2023
Not Applicable
-
Cenobamate 300 mg/d
ydkvdyzwwb(gtkfozbpgl) = lobwgxgdvj jinvrjuccp (dxgyuatktd )
-
04 Sep 2023
Not Applicable
-
64
gklpjzmfcq(ngnkgpnncq) = akeycocxko ojgmvkybir (cyooapbozt )
Positive
04 Sep 2023
Not Applicable
43
flberjvndj(mzgdomstsc) = tdgunxrxbw hsuuanitmh (cruhtkbjcs )
Positive
04 Sep 2023
Not Applicable
-
-
ryjnjojywm(zoearnpoqb) = syxkibqbyy mduityfswx (vnpgsxomsj )
-
04 Sep 2023
Not Applicable
-
-
epsrrhxwxz(ubgcfjcpax) = gaanxwufdm chcowzuzjm (dfjojnmtyh )
-
04 Sep 2023
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Regulation

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