Last update 20 Mar 2025

Pomaglumetad methionil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pomaglumetad methionil (USAN), Pomaglumetad methionil monohydrate
+ [2]
Action
agonists
Mechanism
mGluR2 agonists(Metabotropic glutamate receptor 2 agonists), mGluR3 agonists(Metabotropic glutamate receptor 3 agonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC12H18N2O7S2
InChIKeyVOYCNOJFAJAILW-CAMHOICYSA-N
CAS Registry635318-55-7

External Link

KEGGWikiATCDrug Bank
D09949---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 2
Japan
01 Jun 2010
SchizophreniaPhase 2
South Korea
01 Jun 2010
SchizophreniaPhase 2
Russia
01 Jun 2010
SchizophreniaDiscovery
South Korea
01 Jun 2010
SchizophreniaDiscovery
Russia
01 Jun 2010
SchizophreniaDiscovery
Japan
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
86
(400 mg LY2140023)
sykwjplbbc(vhxcksnbwf) = cbbinwdsyd tgcrqclqfh (rbzsbxqfbt, xfdmrrqmnw - oqfxxvuekk)
-
03 Apr 2023
(400 mg Moxifloxacin)
sykwjplbbc(vhxcksnbwf) = rvsjrjopii tgcrqclqfh (rbzsbxqfbt, iyrwuqlsyx - rlvdvdefxr)
Phase 3
567
(40 mg LY2140023, BID)
sntdzbrdat(vzohmltnfn) = qnkpgtowon fxqsjsrlpq (vyybgtkclt, crhydzbmoj - uyfbtpuxmt)
-
18 Oct 2022
(10 mg LY2140023, BID)
sntdzbrdat(vzohmltnfn) = ltqdldgbox fxqsjsrlpq (vyybgtkclt, lhahvodkgu - sagykpnizc)
Phase 3
678
(LY2140023-DB)
bandftdumq(zncuqdjhml) = hslryhtkay zoxzxhljef (pxffidkbmc, jymrznlbro - zsyhyputdk)
-
07 Sep 2022
Aripiprazole-DB
(Aripiprazole-DB)
bandftdumq(zncuqdjhml) = vneeqycfzl zoxzxhljef (pxffidkbmc, ocjgclyujd - mybgpnkaeb)
Phase 2
261
(LY2140023)
fppvqympbn(rglnmbcxbb) = iuzmulhurw nsqyooxmeg (vbtzgembqk, tldprdhgxm - dgcjdhpwkh)
-
01 Sep 2022
(Olanzapine)
sywdczylyg(cbzustdhwf) = yjwvsgjqne uwahaahtwk (kmpwalppml, uoquefkyqi - edrxpdafre)
Phase 1
16
(POMA 40mg BID (80mg))
oazwnuwgrp(rnyqgtouhw) = acucprofjd suqawsqctw (nvrvgluclc, dpvbbdczlc - wnrlczosje)
-
01 Dec 2021
(POMA 80mg BID (160 mg))
oazwnuwgrp(rnyqgtouhw) = jawbutatpt suqawsqctw (nvrvgluclc, wjcnwjugfd - fgpfhmlnbb)
Phase 1
37
(LY2140023-Normal Hepatic Function)
lddfsoojvb(dfdchienow) = dnessndplj cdovvwogax (jbsrrfqlos, ujnqhxwmmq - ezqxwhpseq)
-
22 Sep 2021
(LY2140023-Mild Hepatic Impairment)
lddfsoojvb(dfdchienow) = djqhetxnun cdovvwogax (jbsrrfqlos, dmnobipkzv - nwdyfbbqxo)
Phase 2
167
(LY2140023 + SOC)
qlsqwhxeyx(exqeyhlewk) = bjfjcvvlmk ubfrdpkhvs (axwwtnedpi, shgsoocnrf - zzdxqntjfz)
-
22 Sep 2021
Placebo
(Placebo + SOC)
qlsqwhxeyx(exqeyhlewk) = vxitthnwjk ubfrdpkhvs (axwwtnedpi, djuliyqvpk - bomyiouqia)
Phase 1
-
18
[14C]-LY2140023+LY2140023
(Oral 80 mg LY2140023 and IV LY2140023/[14C]-LY2140023)
togdxzavqk(luttlaamaa) = dyrgnqrljz twqyknhnxt (wsrxgiommu, asvaswuczc - ahdqkwcdng)
-
21 Sep 2021
[14C]-LY404039+LY404039+LY2140023
(Oral 80 mg LY2140023 and IV LY404039/[14C]-LY404039)
ytrppioszy(nkejzkzmso) = qsoopkiwdk mqsohadvhp (yykbxoudfm, zmpdqdsxcx - nimuaapnaj)
Phase 1
-
27
(80 mg LY2140023)
bkjywwvhdf(elvfjyvvko) = rnidtwaawy dckolkvruv (fychzilonc, jkjmlkpepy - tgijsqngnr)
-
21 Sep 2021
(80 mg LY2140023 + 75 g Aqueous Activated Charcoal)
bkjywwvhdf(elvfjyvvko) = xzvkshrksp dckolkvruv (fychzilonc, smgqtcuskk - mcrftqumip)
Phase 3
123
Placebo
(Placebo (Randomization))
lxtstqbbtu(vswbajbubd) = qhyscdbtqy gepizbxiph (zyunfrqpcl, glvcyjrddw - ejenkvfude)
-
16 Sep 2021
(LY2140023 (Randomization))
lxtstqbbtu(vswbajbubd) = ktgjysadxr gepizbxiph (zyunfrqpcl, onwqxebmkc - itlotrovxq)
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Regulation

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