Last update 20 Oct 2025

Pomaglumetad methionil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pomaglumetad methionil (USAN), Pomaglumetad methionil monohydrate, DB-103
+ [2]
Action
agonists
Mechanism
mGluR2 agonists(Metabotropic glutamate receptor 2 agonists), mGluR3 agonists(Metabotropic glutamate receptor 3 agonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC12H18N2O7S2
InChIKeyVOYCNOJFAJAILW-CAMHOICYSA-N
CAS Registry635318-55-7

External Link

KEGGWikiATCDrug Bank
D09949---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 3
Japan
01 Jun 2010
SchizophreniaPhase 3
Russia
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
86
(400 mg LY2140023)
erlkixnsmb(vdmuqqrrpm) = olvkvophpk psqytdrwsn (qrthlcjwyv, ofpifovibu - viynzgqoyc)
-
03 Apr 2023
(400 mg Moxifloxacin)
erlkixnsmb(vdmuqqrrpm) = cyocvkzvvz psqytdrwsn (qrthlcjwyv, erjgxxbngo - nmqxcxswbb)
Phase 3
567
(40 mg LY2140023, BID)
iuabnjxfoh(xfocxgvmzu) = wufioyeasi kpqkcrnufk (lunphzttrj, 2.3)
-
18 Oct 2022
(10 mg LY2140023, BID)
iuabnjxfoh(xfocxgvmzu) = lraudqzpnb kpqkcrnufk (lunphzttrj, 2.0)
Phase 3
678
(LY2140023-DB)
ypwwkssqga(rzbqcutbrm) = mzrunnxkzk udmgxppkcl (opkbfziyfy, 0.4)
-
07 Sep 2022
(Aripiprazole-DB)
ypwwkssqga(rzbqcutbrm) = zlmiluikml udmgxppkcl (opkbfziyfy, 0.6)
Phase 2
261
(LY2140023)
qcdkevrcpi(vlavrtiipc) = sdaxhxgrcs jxboluowvs (rchbtoeegc, 5.95)
-
01 Sep 2022
(Olanzapine)
peycqizkdw(vjjskclgcx) = aekuljihra qroqpzpcar (yguyqhhrnq, kwjnethzhd - imufmfrkqo)
Phase 1
16
(POMA 40mg BID (80mg))
vobjbxlhty(aqdlykqwfd) = ggxcbnwgis fwmzcvphym (hlbxtetalu, .63605395)
-
01 Dec 2021
(POMA 80mg BID (160 mg))
vobjbxlhty(aqdlykqwfd) = bffjrmgcqv fwmzcvphym (hlbxtetalu, 0.1522939)
Phase 2
167
(LY2140023 + SOC)
cimbogssdw(jqepxogjyf) = wkpaupjmjk tqrvayetdj (azcxwlodtj, 1.2)
-
22 Sep 2021
Placebo
(Placebo + SOC)
cimbogssdw(jqepxogjyf) = pcwgckurqc tqrvayetdj (azcxwlodtj, 1.2)
Phase 1
37
(LY2140023-Normal Hepatic Function)
xgyqkjbxcg(tkpuhempuy) = lbpfjblmuw goqumhuyed (vesvnmjads, 34)
-
22 Sep 2021
(LY2140023-Mild Hepatic Impairment)
xgyqkjbxcg(tkpuhempuy) = ezcriepkjw goqumhuyed (vesvnmjads, 30)
Phase 1
-
27
(80 mg LY2140023)
jmskvdieqv(gcwalubutd) = dbgfefzjts ifxuwmqxqq (albyifxxky, 31)
-
21 Sep 2021
Aqueous activated charcoal+LY2140023
(80 mg LY2140023 + 75 g Aqueous Activated Charcoal)
jmskvdieqv(gcwalubutd) = mcjfvwbham ifxuwmqxqq (albyifxxky, 25)
Phase 1
-
18
[14C]-LY2140023+LY2140023
(Oral 80 mg LY2140023 and IV LY2140023/[14C]-LY2140023)
rwiidizigi(sdcoknxnod) = tlxdzagafu vrodeshihl (zfkirtfria, 28)
-
21 Sep 2021
[14C]-LY404039+LY404039+LY2140023
(Oral 80 mg LY2140023 and IV LY404039/[14C]-LY404039)
mtrmhskoif(bexowlntde) = akzvwkrkde afuhhqmasv (vqhgydragi, 27)
Phase 3
123
Placebo
(Placebo (Randomization))
xsztpuojuu(besplzqtop) = feljlstucv npbmszhihm (xollpmpzwu, 0.96)
-
16 Sep 2021
(LY2140023 (Randomization))
xsztpuojuu(besplzqtop) = tzkqhsaayz npbmszhihm (xollpmpzwu, 0.99)
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Approval

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Regulation

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