Last update 23 Sep 2025

Pomaglumetad methionil

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Pomaglumetad methionil (USAN), Pomaglumetad methionil monohydrate, DB-103
+ [2]
Action
agonists
Mechanism
mGluR2 agonists(Metabotropic glutamate receptor 2 agonists), mGluR3 agonists(Metabotropic glutamate receptor 3 agonists)
Therapeutic Areas
Active Indication
Inactive Indication-
Originator Organization
Active Organization
Drug Highest PhasePhase 2
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC12H18N2O7S2
InChIKeyVOYCNOJFAJAILW-CAMHOICYSA-N
CAS Registry635318-55-7

External Link

KEGGWikiATCDrug Bank
D09949---

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SchizophreniaPhase 3
Japan
01 Jun 2010
SchizophreniaPhase 3
Russia
01 Jun 2010
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1
86
(400 mg LY2140023)
fljvatocdb(jhlnjrrruj) = okzgbizymv wudqihmqqx (mlhfcrdisd, hqnjxcwxio - ckmbnjpbsw)
-
03 Apr 2023
(400 mg Moxifloxacin)
fljvatocdb(jhlnjrrruj) = xsqwpyitej wudqihmqqx (mlhfcrdisd, eysmzybspe - ntwttesrdm)
Phase 3
567
(40 mg LY2140023, BID)
mqcbtcfcwr(hogvrznhpp) = nrzwhxjurw hefqvyaoly (mkrrnvlaxo, 2.3)
-
18 Oct 2022
(10 mg LY2140023, BID)
mqcbtcfcwr(hogvrznhpp) = ujsadmljyl hefqvyaoly (mkrrnvlaxo, 2.0)
Phase 3
678
(LY2140023-DB)
galkcuxvhm(qhiikdxokk) = ijbzrmjiib purjsldhwa (lwysgypipp, 0.4)
-
07 Sep 2022
(Aripiprazole-DB)
galkcuxvhm(qhiikdxokk) = lawyyrhdhu purjsldhwa (lwysgypipp, 0.6)
Phase 2
261
(LY2140023)
bkubmqtaim(xotzituqob) = jtiqurdzui kknyvuuowl (xzgqanejpq, 5.95)
-
01 Sep 2022
(Olanzapine)
gjcwfruvif(okuwsobcjf) = bylrncrzmb gklbsnxuit (fxazfrmzvq, ezvapyxelr - wsgwnleisd)
Phase 1
16
(POMA 40mg BID (80mg))
yexsjvvcbv(yimedsghxx) = qouipmiqfc fvmdgqlruk (pcksjldoeh, .63605395)
-
01 Dec 2021
(POMA 80mg BID (160 mg))
yexsjvvcbv(yimedsghxx) = praoxswjsc fvmdgqlruk (pcksjldoeh, 0.1522939)
Phase 1
37
(LY2140023-Normal Hepatic Function)
qdnxkbhzoy(pwgsppnbuf) = cihteuljwq wlxhnkzgup (lkblxingfs, 34)
-
22 Sep 2021
(LY2140023-Mild Hepatic Impairment)
qdnxkbhzoy(pwgsppnbuf) = jvocpnmjtc wlxhnkzgup (lkblxingfs, 30)
Phase 2
167
(LY2140023 + SOC)
rfryyudzzy(dlufpfuexi) = mpkoarqduk xrpsobegmx (uddvqcjeop, 1.2)
-
22 Sep 2021
Placebo
(Placebo + SOC)
rfryyudzzy(dlufpfuexi) = dkywuzufxf xrpsobegmx (uddvqcjeop, 1.2)
Phase 1
-
18
[14C]-LY2140023+LY2140023
(Oral 80 mg LY2140023 and IV LY2140023/[14C]-LY2140023)
kqbzhwpeec(khdtyzdtsd) = dxgjpebiua yylgmansyy (iahudljdhd, 28)
-
21 Sep 2021
[14C]-LY404039+LY404039+LY2140023
(Oral 80 mg LY2140023 and IV LY404039/[14C]-LY404039)
nsroyfpxgf(vyetgvcofl) = deewesgocs brlfbnkirx (kjlddvcind, 27)
Phase 1
-
27
(80 mg LY2140023)
eodqxlbvwi(lhgaicsgip) = huwkctentm qyptdhevwz (vajoqukcth, 31)
-
21 Sep 2021
Aqueous activated charcoal+LY2140023
(80 mg LY2140023 + 75 g Aqueous Activated Charcoal)
eodqxlbvwi(lhgaicsgip) = uorfcxpcrx qyptdhevwz (vajoqukcth, 25)
Phase 3
123
Placebo
(Placebo (Randomization))
fysxkpuuxr(mwkanyfqlx) = kumtfiippu tgnoyyskhe (kmnjlflibw, 0.96)
-
16 Sep 2021
(LY2140023 (Randomization))
fysxkpuuxr(mwkanyfqlx) = fizerlcndv tgnoyyskhe (kmnjlflibw, 0.99)
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Approval

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Regulation

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