Last update 13 Nov 2024

Clofutriben

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
ASP-3662, ASP3662, SPI-62
Target
Mechanism
11β-HSD1 inhibitors(Corticosteroid 11-beta-dehydrogenase isozyme 1 inhibitors)
Inactive Indication-
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC19H16ClF3N4O2
InChIKeyCMQOKZCYVZFZLZ-UHFFFAOYSA-N
CAS Registry1204178-50-6

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acrocallosal SyndromePhase 2
US
01 Jul 2023
Acrocallosal SyndromePhase 2
RO
01 Jul 2023
Acrocallosal SyndromePhase 2
GB
01 Jul 2023
Acth-Independent Macronodular Adrenal HyperplasiaPhase 2
US
01 Jul 2023
Acth-Independent Macronodular Adrenal HyperplasiaPhase 2
RO
01 Jul 2023
Acth-Independent Macronodular Adrenal HyperplasiaPhase 2
GB
01 Jul 2023
Adrenocortical AdenomaPhase 2
US
01 Jul 2023
Adrenocortical AdenomaPhase 2
RO
01 Jul 2023
Adrenocortical AdenomaPhase 2
GB
01 Jul 2023
Cushing SyndromePhase 2
BG
01 Sep 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
40
bwzqvxomew(giqkdpybku) = A combination of prednisolone 20 mg with clofutriben showed similar efficacy as prednisolone 10 mg with placebo, based on analysis of participants’ symptoms, physical function, and biomarkers of inflammation. hqwhqpqlye (stqnneqmjg )
Positive
19 Sep 2024
SPI-62 + placebo
Phase 2
-
fvpojlumee(bsyujiugyd) = Prednisolone 10mg combined with clofutriben 6mg demonstrated less efficacy compared to prednisolone 10mg administered with placebo, Prednisolone 20mg combined with clofutriben 6mg demonstrated similar efficacy as determined by symptoms, physical function, and systemic inflammation, tikkhuorxk (znffcuqacp )
Positive
15 Jun 2024
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Approval

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Regulation

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