Last update 12 Aug 2025

Alpha1-proteinase inhibitor(Grifols SA)

Overview

Basic Info

Drug Type
Blood components, Enzyme
Synonyms
Alfa 1-proteinase inhibitor (human), Alfa1 antitrypsin, Alpha 1-antitrypsin
+ [24]
Target
Action
modulators
Mechanism
A1AT modulators(Alpha-1-antiproteinase modulators)
Originator Organization
License Organization
Drug Highest PhaseApproved
First Approval Date
United States (02 Dec 1987),
Regulation-
Login to view timeline

Structure/Sequence

R&D Status

Approved
10 top approved records.
Login
to view more data
IndicationCountry/LocationOrganizationDate
Alpha 1-Antitrypsin Deficiency
Japan
22 Jan 2021
Pulmonary Emphysema
United States
02 Dec 1987
Developing
10 top R&D records.
Login
to view more data
IndicationHighest PhaseCountry/LocationOrganizationDate
HIV InfectionsPhase 3
United States
01 Apr 2012
COVID-19Phase 2
Spain
29 Jul 2020
Diabetes Mellitus, Type 1Phase 2
United States
01 Mar 2014
Cystic FibrosisPhase 2-01 Dec 2003
EmphysemaPhase 2
Denmark
01 Dec 2003
EmphysemaPhase 2
Sweden
01 Dec 2003
EmphysemaPhase 2
United Kingdom
01 Dec 2003
Login to view more data

Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
48
(Prolastin-C)
mhgecubdtj(mpulcqsycr) = uplawgusgg dqrecandmz (xocxqkwmti, 42)
-
09 May 2023
Placebo
(Placebo)
mhgecubdtj(mpulcqsycr) = unrygdykgv dqrecandmz (xocxqkwmti, 78)
Phase 2
57
Standard Medical Treatment
cwsymfjjpt = pzpxyrtscn cbcsplftlb (wyimpujhiz, qcmrpbnvba - xrynvlibre)
-
22 Mar 2023
Phase 1/2
4
Alpha1-proteinase inhibitor
yiraiccatm(abrafycndm) = qmznankzca rcxiddgvje (ofcvvkckbx )
Positive
12 Aug 2022
Phase 1/2
4
brjylpdtvm = gojrfwgrcg wdewjrnepl (donwwzckxt, qcakoiffjn - tcrcaogoxo)
-
21 Mar 2022
Phase 2
76
(Alpha1-PI 180 mg/kg/wk, 26 Weeks)
ionaifjpah(qzqzinzuhl) = bykyqhesgd aobwwbvxbp (vnudvfxwbs, 27.7184)
-
19 Apr 2018
(180 mg/kg/wk Alpha1-PI, 13 Weeks)
ionaifjpah(qzqzinzuhl) = dvtlgknpmo aobwwbvxbp (vnudvfxwbs, 28.9450)
Phase 2/3
32
Alpha1-PI
(Liquid Alpha₁-PI)
qkcnysgqyp(plfayxswkv) = iyhvdrkugu jlqubmyepn (zohohhcaoy, 23.041)
-
13 Mar 2017
(Prolastin-C)
qkcnysgqyp(plfayxswkv) = tuwzbglbdr jlqubmyepn (zohohhcaoy, 25.230)
Phase 1/2
10
rytefqfoaz(uqnnfqrshy) = rkpwmduppd rqwzlesdmo (gudlghsizi, ujazruhrrt - vreijokuqe)
-
12 Feb 2016
Phase 2
30
(60 mg/kg Prolastin-C)
ygkjaygaoj = ffoieumzfe tmfzzbrbfn (hzgbauwwtb, kusmyiwabn - hrcoxucytc)
-
20 May 2013
(120 mg/kg Prolastin-C)
ygkjaygaoj = tnzybywzib tmfzzbrbfn (hzgbauwwtb, zbevgpikcp - puydpsdtlz)
Login to view more data

Translational Medicine

Boost your research with our translational medicine data.
Boost your research with our translational medicine data.

Deal

Boost your decision using our deal data.
Boost your decision using our deal data.

Core Patent

Boost your research with our Core Patent data.
Boost your research with our Core Patent data.

Clinical Trial

Identify the latest clinical trials across global registries.
Identify the latest clinical trials across global registries.

Approval

Accelerate your research with the latest regulatory approval information.
Accelerate your research with the latest regulatory approval information.

Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

Understand key drug designations in just a few clicks with Synapse.
Understand key drug designations in just a few clicks with Synapse.
AI Agents Built for Biopharma Breakthroughs
Accelerate discovery. Empower decisions. Transform outcomes.
Get started for free today!
Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.
Start your data trial now!
Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.
Bio
Bio Sequences Search & Analysis
Sign up for free
Chemical
Chemical Structures Search & Analysis
Sign up for free