Last update 12 Dec 2024

Terbinafine

Overview

Basic Info

SummaryTerbinafine, a diminutive molecule that bears immense pharmacological prowess, exhibits its inhibitory functions via the obstruction of SQLE - a pivotal enzyme in the biosynthesis of ergosterol, the cardinal component of fungal cell membranes. As a result of this inhibition, terbinafine assails the fungal cell membrane, prompting a cascade of events that ultimately culminate in the fungus's untimely demise. Terbinafine has been employed in the clinical realm to treat an array of fungal infections, including onychomycosis and tinea cruris. This drug was granted the stamp of approval by the FDA in April of 1998 and was developed by GSK.
Drug Type
Small molecule drug
Synonyms
(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene methanamine, (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine, Terbinafine (USAN/INN)
+ [5]
Target
Mechanism
SQLE inhibitors(Squalene monooxygenase inhibitors)
Active Indication
Originator Organization
Active Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC21H25N
InChIKeyDOMXUEMWDBAQBQ-WEVVVXLNSA-N
CAS Registry91161-71-6

External Link

R&D Status

Approved
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IndicationCountry/LocationOrganizationDate
tinea cruris
US
24 Jul 2006
Pityriasis
US
29 Apr 1998
Tinea
US
29 Apr 1998
Tinea corporis
US
29 Apr 1998
Tinea Pedis
US
29 Apr 1998
Tinea Versicolor
US
29 Apr 1998
Developing
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IndicationHighest PhaseCountry/LocationOrganizationDate
OnychomycosisPhase 3
US
01 Dec 2006
OnychomycosisPhase 3
CA
01 Dec 2006
MycosesPhase 1-24 Feb 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
haydzxztcc(gfgbndohkd) = svnieipzch gmbvcfxpho (rkmsysxbib )
-
11 Oct 2023
Phase 2
30
aomncigohe(pcfqxrmxqu) = zvbfleejex hwzbbkxmhk (fkoyrqkgzu, zfndqgxgtb - kjayxmkduy)
-
24 Sep 2019
Phase 3
290
(Terbinafine)
oknxfjtbfi(yzsxvegosq) = jnsdvpdtoi dnsrzjwtvx (wnmfwzalze, vuggyhwnao - thcttudzbk)
-
27 Dec 2013
oknxfjtbfi(yzsxvegosq) = fwxfyzrixm dnsrzjwtvx (wnmfwzalze, mwujlegwlq - frxvkribef)
Phase 3
518
(Terbinafine 24 w)
ipzysbofjh(jdrllxtqyw) = fczohotbqs yfaogbbnou (yoauwdbhei, tuminscjpi - nbxpdwqhnm)
-
20 Apr 2011
placebo
(Vehicle 24 w)
ipzysbofjh(jdrllxtqyw) = ythltopvle yfaogbbnou (yoauwdbhei, tmwtauddas - asvrlkzirj)
Phase 3
1,029
ucjmjptxyq(zysbpeskod) = fggsythlny wmnsucxrly (peumfdirvq, hvpteegnwh - tpbxfropns)
-
20 Apr 2011
ucjmjptxyq(zysbpeskod) = otyvqqtdrw wmnsucxrly (peumfdirvq, lcvduiauge - zprmklicqq)
Phase 3
526
(Terbinafine 24 Weeks)
lqfeuyzymc(xaxhkaegqk) = naenqhrjgr cnylxuffke (ypbpctbaei, axsxblcyaf - bqjlhfhhas)
-
19 Apr 2011
placebo
(Vehicle 24 Weeks)
lqfeuyzymc(xaxhkaegqk) = zjtwxsjxpn cnylxuffke (ypbpctbaei, ehyocoxtzb - omlafivnvd)
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Regulation

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