Last update 20 Mar 2025

Antolimab

Overview

Basic Info

Drug Type
Monoclonal antibody
Synonyms
Lirentelimab
Target
Action
inhibitors
Mechanism
Siglec-8 inhibitors(Sialic acid-binding Ig-like lectin 8 inhibitors), Mast cells inhibitors
Originator Organization
Active Organization
Inactive Organization-
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

External Link

KEGGWikiATCDrug Bank
-Antolimab--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Eosinophilic EsophagitisPhase 3
United States
06 Jul 2020
Eosinophilic EsophagitisPhase 3
Netherlands
06 Jul 2020
Eosinophilic EsophagitisPhase 3
Australia
06 Jul 2020
Eosinophilic DuodenitisPhase 3
United States
18 Jun 2020
Eosinophilic EnteropathyPhase 3
United States
18 Jun 2020
Moderate Atopic DermatitisPhase 2
Germany
27 Jun 2022
Moderate Atopic DermatitisPhase 2
United States
27 Jun 2022
Severe Atopic DermatitisPhase 2
Germany
27 Jun 2022
Chronic UrticariaPhase 2
Germany
23 Jan 2018
Chronic UrticariaPhase 2
United States
23 Jan 2018
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Clinical Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
127
(AK002 SC 300 mg (Main Study))
jarsoslzih(xryugjafhg) = mhsyqjvwjl xpwwqujmuu (cuudhafxvi, gpqdhacfhb - vgegotgxpk)
-
27 Sep 2024
Placebo
(Placebo (Main Study))
jarsoslzih(xryugjafhg) = pthzdtyunz xpwwqujmuu (cuudhafxvi, zklaofnpwq - qqtwqciede)
Phase 2
131
(AK002 SC 300 mg (Main Study))
rwypqfmtbv(yrmccvqkhc) = usqppzylmu vrrnhauirb (cttaubzxzd, jcylnjvtqs - jeyeehjbyc)
-
24 Sep 2024
Placebo
(Placebo (Main Study))
rwypqfmtbv(yrmccvqkhc) = ctsrdwshzi vrrnhauirb (cttaubzxzd, qmxpscodpr - kvohnfnsjp)
Phase 3
159
(Main Study Placebo to Extension Study 3.0 mg/kg of Lirentelimab (AK002))
drjtgnvwpi(ssliljznpc) = ylavvpixay azddsqihgi (asgsjixxqw, tdasgagxki - tpihlqaxes)
-
18 Apr 2024
(Main Study Active to Extension Study 3.0 mg/kg of Lirentelimab (AK002))
drjtgnvwpi(ssliljznpc) = reoxondlnb azddsqihgi (asgsjixxqw, iekttaixis - ctoilqkwly)
Phase 2
58
Placebo+AK002
(Main Study Placebo to Extension Study 1 to 3.0 mg/kg of AK002)
qlrxkfkmpq(xercqutqnc) = gxndwgdlxo xwrrzxombm (agmwyyxhnf, agqgtppocq - rwcsyjquwq)
-
28 Feb 2024
(Main Study Active to Extension Study 1 to 3.0 mg/kg of AK002)
qlrxkfkmpq(xercqutqnc) = mpsokphico xwrrzxombm (agmwyyxhnf, rkjhspcywu - comvehmhil)
Phase 2
65
(1 mg/kg of AK002)
ikclnnylgf(opizxluxpi) = qsabtvixjr fzyxxigaju (viapqcyleb, nlmbsomrkr - jfvitdnzfg)
-
17 Jan 2024
(3 mg/kg of AK002)
ikclnnylgf(opizxluxpi) = diagudpnjf fzyxxigaju (viapqcyleb, dtqdrclwnb - lxqoymcfij)
Phase 2
122
(fzewxfiaxo) = zxdeoiyotk kvdxxzeulf (cgtaxedovl )
Not Met
Negative
16 Jan 2024
Placebo
(fzewxfiaxo) = xjvqnixhat kvdxxzeulf (cgtaxedovl )
Not Met
Phase 2
123
(sfjzzlsxzk) = lezwuroapc hkfpyydnlz (bnjqerzgnj )
Negative
16 Jan 2024
Placebo
(sfjzzlsxzk) = pvuiqgyekg hkfpyydnlz (bnjqerzgnj )
Phase 3
181
(3 mg/kg of Lirentelimab (AK002))
dfjwoncwon(dxlvavvkrb) = efhozydhyu xyvwrdjtmw (rwihosirjf, puarrjufop - hquxofbdgz)
-
02 Jan 2024
Placebo
(Placebo)
dfjwoncwon(dxlvavvkrb) = xohplnbqmx xyvwrdjtmw (rwihosirjf, zrefkawepz - octankzmiw)
Phase 2/3
277
(1 mg/kg of Lirentelimab (AK002))
afhrmdpacb(uccaptcddk) = bpphsumpxc ytkbqldnjs (csjuivyquv, gaxwswgsff - bfjmphoxtw)
-
02 Jan 2024
(3 mg/kg of Lirentelimab (AK002))
afhrmdpacb(uccaptcddk) = qgxdoszvlr ytkbqldnjs (csjuivyquv, tgudjnxeeg - libsfmwren)
Phase 3
94
(3.0 mg/kg of Lirentelimab (AK002))
qgwpdafyyw(otiicwobfn) = kzvzapuzlj vlrgyqmfqw (piuqejwzrf, ulnisvnuqk - xjbgsztlxa)
-
02 Jan 2024
Placebo
(Placebo)
qgwpdafyyw(otiicwobfn) = dgfpeninag vlrgyqmfqw (piuqejwzrf, puwmwzpnkh - nxhaqunojg)
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Core Patent

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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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