Efficacy of Sage Extract or Chlorohexidine Mouthwashes on Streptococcus Mutans Pathogenicity by Real-time Polymerase Chain Reaction (PCR) in High Caries Risk Patients : A Randomized Clinical Trial

In patients with high caries risk, will the use of sage extract or chlorohexidine based mouthwashes have an effect on the percentage recovery of Streptococcus Mutans (SM) and its pathogenicity detected by Real-Time Polymerase Chain Reaction (PCR) over one month follow up

Start Date06 Jul 2021

Sponsor / Collaborator

Cairo University

NCT02032862 / TerminatedPhase 4

Multicentric, Randomized, Double Blind Study for Assessment of Efficacy and Tolerability of Sage Tablets Compared to Placebo in Menopausal Patients With Hot Flushes and Sweating

Sage tablets ( 3400 mg extract from fresh sage leaves, DER 1:17) in a once daily application over 12 treatment weeks are compared against placebo in 200 menopausal patients with ≥ 5 hot flushes daily and a Hyperhidrosis Scale score ≥ 2

Start Date01 Dec 2013

Sponsor / Collaborator

A. Vogel AG

100 Clinical Results associated with Salvia officinalis Extract

100 Translational Medicine associated with Salvia officinalis Extract

100 Patents (Medical) associated with Salvia officinalis Extract

Literatures (Medical) associated with Salvia officinalis Extract

30 Jun 2024·Anatomy & Cell Biology

Sage (Salvia officinalis) alleviates trazadone induced rat cardiotoxicity mediated via modulation of autophagy and oxidative stress

Article

Author: Safwat, Marwa Mohamed ; Al-Gholam, Marwa Abdel-Samad ; Essawy, Asmaa Saeed ; Hathout, Heba Moustafa Rasheed

The antidepressant drug trazodone (TRZ) is commonly used for treating depression, anxiety, and insomnia, however, it causes cardiotoxicity, which is one of its limitations. The objective of this work was to investigate the impact of sage (Salvia officinalis) in rats against cardiotoxicity induced by TRZ and to investigate the mechanisms involved in its cardio-protective properties through autophagy and oxidative stress. Fifty male albino rats were split randomly into five experimental groups: control group, sage oil group (100 mg/kg), TRZ group (20 mg/kg), protective group, and curative group. Cardiac function biomarkers (aspartate aminotransferase [AST], creatine kinase-MB [CK-MB], and cardiac troponin T [cTnI]) were assessed in serum. Oxidative stress and inflammatory biomarkers in cardiac tissue (total antioxidant capacity, malondialdehyde, and tumor necrosis factor-α) were evaluated. Heart tissues were subjected to histological, immunohistochemical, and ultrastructural evaluations. DNA damage also evaluated. Significant rise in the levels of AST, CK-MB, and cTnI were observed with enhanced autophagy along with marked histopathological changes in the form of interrupted muscle fibers with wide interstitial spaces with areas of hemorrhage and extravasated blood and interstitial mononuclear cellular infiltration in TRZ group. DNA damage was also significantly increased in TRZ group. However, administration of sage in both protective and curative groups show marked improvement of the cardiac alterations. In conclusion, sage ameliorated the alterations in the heart induced by trazadone through modulation of autophagy and oxidative stress.

19 Apr 2024·Cureus

Clinical Effectiveness of Salvia officinalis in Periodontitis: A Split-Mouth Randomized Controlled Trial

Article

Author: Mahmood, Maha S ; Aljuboori, Ismael W ; Al-Rihaymee, Sarah A

Background Periodontitis is a chronic inflammatory condition that destroys the tissues supporting the teeth. Conventional nonsurgical treatments, such as mechanical scaling and root surface debridement (RSD), often require adjunct therapies to enhance outcomes due to their limited efficacy in completely eradicating pathogenic microorganisms. Given the adverse effects of standard adjunctive therapies, including antibiotics and nonsteroidal anti-inflammatory drugs, Salvia officinalis (sage) presents a promising herbal alternative due to its anti-inflammatory and antimicrobial properties. This study aims to assess the local application of Salvia officinalis gel as an adjunctive to scaling and RSD to manage periodontitis. Methods We conducted a randomized, controlled split-mouth clinical trial involving 14 systemically healthy periodontitis patients. We included patients with at least 20 natural teeth, a probing pocket depth (PPD) ≥5 mm, and attachment loss ≥4 mm at a minimum of five sites. Primary outcomes measured were bleeding on probing (BOP), PPD, and relative attachment level (RAL). The Salvia officinalis gel was applied to designated test sites post-RSD, while control sites received no adjunctive treatment. Clinical parameters were recorded at baseline and a one-month follow-up visit. Results The cohort consisted of 10 men and four women, with a mean age of 37.1 ± 5.46 years. At the follow-up visit, the test group demonstrated a significant reduction in mean BOP (P = 0.0004), whereas the control group showed no significant change (P ≥ 0.05). Both groups experienced significant decreases in mean PPD and RAL from baseline to follow-up, with the test group showing greater improvements. Conclusions Salvia officinalis gel, used as an adjunct to scaling and RSD, significantly improves clinical periodontal parameters in patients with periodontitis. Its anti-inflammatory properties likely underpin the observed benefits, offering an effective and safe alternative to traditional chemical pharmaceuticals. Further research is needed to explore the long-term effects and mechanisms underlying the therapeutic benefits of Salvia officinalis in periodontal treatment.

01 Apr 2024·Veterinary Research Communications

Effects of sage (Salvia officinalis) essential oil on growth, health and antioxidant capacity of common carp (Cyprinus carpio)

Article

Author: Aslankoc, Rahime ; Metin, Secil ; Yigit, Nalan Ozgur ; Kara, Nimet ; Didinen, Behire Isil ; Ozmen, Ozlem ; Koca, Seval Bahadir

In the study, effects of S. officinalis essential oil on growth performance, health and antioxidant activity in C. carpio were investigated. The fish (13 ± 0.21 g) were fed with diet containing 1 and 3 ml kg^- 1 of sage oil for 60 days. At the end of study, growth performance was not affected in fish fed with sage essential oil (p > 0.05). Superoxide dismutase (SOD) activity in hepatopancreas increased with addition of 1ml kg^- 1 sage oil to the diet. However, Catalase (CAT) activity and malondialdehyde (MDA) values were not significantly altered in common carp. Total protein, albumin, glucose and hepatopancreas enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP)) in blood serum were not affected by sage essential oil supplementation. At the histological examinations, no pathological findings were observed in hepatopancreas and intestine of carp. Goblet cells number and villi length in intestine increased with sage supplementation (p < 0.001). In addition, fertility, granulation and number of follicles increased in common carp fed with sage essential oil. Mortality after challenged with A. hydrophila was not observed in carp fed with 1ml kg^- 1 concentration of sage essential oil. As a result, use of sage oil can be recommended in carp farming to improve gut health, provide disease resistance against A. hydrophila infection, and increase of fertility.

100 Deals associated with Salvia officinalis Extract

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Indication	Highest Phase	Country/Location	Organization	Date
Hyperlipidemias	Phase 3	IR	-	22 Dec 2009

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


MDS2020	Phase 1	Essential Tremor	-	SAGE-324 45mg	(xifhpczekp) = 2/6 [33.3%] in 45 mg group, 2/5 [40.0%] in 60 mg group ggpgzvsobm (kcueojkqba ) View more	-	12 Sep 2020
				SAGE-324 60mg

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