mRNA-based technology has been evaluated in clinical trials for rapid control and prevention of emergencies and diseases. HC009, a mRNA vaccine encoding the full-length SARS-CoV-2 spike protein delivered via the QTsome platform, was tested in rats for immunogenicity, toxicity, and biodistribution. For immunogenicity and toxicity, rats received three intramuscular injections of HC009 at 3-week intervals followed by a 4-week observation period. In the biodistribution study, rats received a single intramuscular injection, with mRNA levels measured in organs at various time points. Results showed that HC009 elicited effective, long-lasting humoral immunity and Th1-biased cellular responses. The mRNA primarily localized to the injection site and spleen, with no observed vaccine-related toxicological reactions. These findings support HC009's potential for inducing an effective immune response with a favorable safety profile, warranting further clinical investigation.

01 Feb 2008·Journal of the American Chemical SocietyQ1 · CHEMISTRY

Aligned Inclusion of Dipolar Dyes into Zeolite Channels by Inclusion in the Excited State

Q1 · CHEMISTRY

Article

Author: Kim, Hyun Sung ; Pham, Tung Thanh ; Yoon, Kyung Byung

Unlike octadecyl-tethering hemicyanine (HC-18), nonyl-tethering hemicyanine (HC-9) entered the hydrophobic channels of silicalite-1 with a very small preference to the inclusion with the alkyl part first.Accordingly, while the degree of uniform orientation (DUO) of HC-18 in the channels was 0.67, that of HC-9 was only 0.08.This phenomenon was ascribed to the fact that HC-9 has a hydrophilic part at the center and two hydrophobic parts on both sides with almost equal hydrophobicities.Upon irradiation of the HC-9 dyes oriented parallel to the channel direction of silicalite-1 on the surface of the silicalite-1 film at 5 °C with a laser beam derived from an Ar⁺-ion laser (488 nm, 1.6 W), the DUO of the included HC-9 increased to 0.27.This phenomenon was attributed to the inclusion of HC-9 into the silicalite-1 channels in the excited-state in accordance with the phenomenon that the hydrophilic center shifts to the very end of the mol. (di-Me amino group) in the excited state, giving rise to lengthening of the relatively hydrophobic region.

100 Deals associated with HC009( Beijing Houcheng)

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Indication	Highest Phase	Country/Location	Organization	Date
Diminished ovarian reserve	IND Approval	China	Beijing Houcheng Medical Technology Co., Ltd.	21 Jan 2025

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