Prospective Open-label Single-arm Single-center Clinical Trial Study on Wuji Baifeng Tablets in the Monotherapy of Ovarian Reserve Dysfunction of Qi and Blood Deficiency Type

Start Date01 May 2025

Sponsor / Collaborator-

ITMCTR2025000711

/ SuspendedNot ApplicableIIT

The Regulatory Effect of Cai's Gynecological Kidney-Nourishing Method on Diminished Ovarian Reserve

Start Date15 Apr 2025

Sponsor / Collaborator-

ITMCTR2025000576

/ SuspendedNot ApplicableIIT

Study on the central mechanism of acupuncture in DOR based on functional magnetic resonance imaging

Start Date07 Apr 2025

Sponsor / Collaborator-

100 Clinical Results associated with Diminished ovarian reserve

100 Translational Medicine associated with Diminished ovarian reserve

0 Patents (Medical) associated with Diminished ovarian reserve

233

Literatures (Medical) associated with Diminished ovarian reserve

01 Aug 2025·Reproductive Toxicology

Exposure to disinfection by-products and risk of diminished ovarian reserve: Case-control evidence and cellular metabolomic insights

Article

Author: Fang, Ying ; Zhao, Xuehan ; Tian, Yichang ; Wang, Zelin ; Wu, Jiaqi ; Wang, Cong ; Wang, Qin ; Zhang, Jing ; Yang, Xiaokui ; Yang, Yi

Disinfection of drinking water is a critical measure for ensuring water safety and controlling waterborne infectious diseases. However, during the disinfection process, a variety of disinfection by-products (DBPs), some of which exhibit reproductive toxicity, are generated. This study aimed to assess whether DBP exposure contributes to the risk of diminished ovarian reserve (DOR) and explored the underlying metabolic mechanisms. A total of 182 participants, including 91 healthy women and 91 women with DOR, were recruited for a case-control study conducted between October 2023 and February 2024. Serum concentrations of DBPs, including dibromoacetic acid (DBAA), monochloroacetic acid (MCAA), dichloroacetic acid (DCAA), trichloroacetic acid (TCAA), chlorate, and perchlorate, were measured to evaluate DBP exposure. Key indicators for evaluating DOR included antral follicle count (AFC), anti-Mullerian hormone (AMH), and follicle-stimulating hormone (FSH). All six DBPs were higher in DOR patients (all p < 0.05). After controlling for covariates, all DBPs showed negative correlations with AMH and AFC, positive correlations with basal FSH, and a significant association with the risk of DOR (all p < 0.05). To further investigate the underlying mechanisms, we conducted an in vitro study using human ovarian granulosa cell line (KGN). KGN cells were exposed to DBAA and perchlorate for 48 hours, and metabolomic analysis was performed to identify altered metabolic pathways. Metabolomics data suggested that DBAA and perchlorate might have contributed to DOR by disrupting arginine biosynthesis and purine metabolism, respectively. In conclusion, DBPs exposure might have contributed to DOR risk by disrupting granulosa cell (GC) metabolism.

01 May 2025·eBioMedicine

CKAP5 deficiency induces premature ovarian insufficiency

Article

Author: Xiao, Hongmei ; Quan, Ruping ; Gao, Jingping ; Chen, Jianlin ; Long, Panpan ; Jiang, Jixuan ; Hu, Zihao ; Zhang, Jing ; Huang, Fei ; Huang, Hualin

BACKGROUNDPremature ovarian insufficiency (POI) is characterized by ovarian dysfunction that develops from diminished ovarian reserve (DOR). The exact aetiology of POI remains poorly understood. This study aims to elucidate the role of CKAP5 in the regulation of ovarian function and fertility.METHODSBulk RNA sequencing of granulosa cells was conducted in the control group and in the patients with DOR to screen for candidate genes, which were further validated by gene burden analysis in a next-generation sequencing cohort of POI and control individuals. Additionally, ovarian reserve was evaluated in heterozygous Ckap5 knockout mice, alongside the ovarian and oocyte single-cell transcriptome analysis. The regulatory mechanism of CKAP5 was studied through in vivo and in vitro experiments.FINDINGSCKAP5 was identified as a key hub gene associated with ovarian ageing. Heterozygous Ckap5 knockout mice exhibited a POI-like phenotype, characterized by a reduced primordial follicle pool and accelerated follicular atresia. CKAP5 promotes autophagy via ATG7 and simultaneously supports DNA damage repair through the ATM. Finally, a variant in CKAP5 (NM_0001008938.4, c.630 + 7_630 + 11delCAAAA) was identified in patients with POI, resulting in protein truncation and loss of function.INTERPRETATIONCKAP5 deficiency induces premature ovarian insufficiency in both humans and mice.FUNDINGThe National Key R&D Program of China (2017YFC1001100), the National Natural Science Foundation of China (81501248, 81471453 and 81801295), the Health Research Project of Hunan Provincial Health Commission (W20243018), the Science and Technology Innovation Program of Hunan Province (2021RC3031), the National Natural Science Foundation of Hunan Province (2022JJ30066), the Scientific Research Program of Hunan Provincial Health Commission (202205033471 and 21B0058), the Open Research Fund of Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects Prevention and Control (HPKL2023013).

01 Apr 2025·Reproductive Sciences

The Mechanistic Study of Mitochondrial Autophagy and Ferroptosis in the Progression of Decreased Ovarian Reserve

Article

Author: Ma, Qianwen ; Wang, Jiajia ; Ni, Binfei ; Song, Shiyan ; Wu, Lifei ; Wu, Jianfei

OBJECTIVETo investigate the mechanism in the progression of decreased ovarian reserve (DOR).METHODSThree-month-old female SD rats were employed and randomly divided into the model group and the normal group. The model group was intraperitoneally injected with 4-vinylcyclohexene diepoxide (VCD). Thereafter, blood sample from the abdominal aorta was taken, and rats were sacrificed, and ovarian tissues were obtained by laparotomy.RESULTSHE staining results revealed that the model group exhibited significantly reduced ovarian volume, increased follicular atresia, and decreased quantities of growing follicles and corpus luteum, thereby indicating degraded reserve function of ovarian. TEM images revealed that prominent autophagic vacuoles could be observed in the model group, accompanied by the mitochondria shrinkage and generation of the autophagosome. The expression of Pink1, Parkin, BNIP3L and LC3II genes in ovaries of the model group was significantly higher than those of the normal group (P < 0.05). In addition, the protein expression of Pink1, Parkin, BNIP3L and LC3II in ovaries of the model group were higher than those of the normal group (P < 0.05). The expression of Fe²⁺ and GSH in oocytes of the model group was higher than those of the normal group (P < 0.05). The expression of FTH1 and GPX4 in oocytes of the model group was significantly higher than those of the normal group (P < 0.05).CONCLUSIONSMitochondrial autophagy and ferroptosis may participate in the progression of decreased ovarian reserve (DOR).

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