Last update 01 Nov 2024

MZRW

Last update 01 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Herbal medicine

Synonyms

Fructus Cannabis (HuoMaRen), Radix et Rhizoma Rhei (DaHuang), Radix Paeoniae Alba (BaiShao), Semen Armeniacae Amarum (KuXingRen), Fructus Aurantii Immaturus (ZhiShi) and Cortex Magnoliae Officinalis (HouPo).

Target-

Mechanism-

Therapeutic Areas

Digestive System DisordersOther Diseases

Active Indication-

Inactive Indication

Constipation - functionalGastrointestinal Diseases

Originator Organization

Hong Kong Baptist University

Active Organization-

Inactive Organization

Hong Kong Baptist University

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

Clinical Trials associated with MZRW

NCT02359396 / CompletedPhase 1IIT

Effects of Oral Administration of a Chinese Proprietary Medicine, MZRW on Tolerability, Exposure and Pharmacokinetics in Healthy Subjects

This is a randomized open-label, three-arm, phase 1 clinical study. The investigators aim to investigate a Chinese Proprietary Medicine, MZRW on its tolerability, system exposure and pharmacokinetics profile.

Start Date01 Nov 2014

Sponsor / Collaborator

Hong Kong Baptist University

100 Clinical Results associated with MZRW

100 Translational Medicine associated with MZRW

100 Patents (Medical) associated with MZRW

Literatures (Medical) associated with MZRW

01 Dec 2022·Chinese Medicine

A pilot randomized placebo-controlled study on modified MaZiRenWan: a formulated Chinese medicine to relieve constipation for palliative cancer patients

Article

Author: Zhong, Linda L D ; Ng, Bacon F L ; Bian, Zhao-Xiang ; Kang, Yu-Chen ; Cheng, Chung-Wah ; Lam, Pui-Yan ; Chan, Jasmine T M ; Tse, Doris M W ; Mok, Hoi-Fung ; Yau, Cora W S ; Zhao, Chen ; Kwok, Annie O L

AbstractBackgroundConstipation is a common problem among advanced cancer patients; however, many of them find limited effective from current therapies. Thus, we aimed to test the effect of a traditional Chinese herbal formula, modified MaZiRenWan (MZRW), by comparing with placebo among palliative cancer patients with constipation.MethodsThis is a randomized, double-blind, placebo-controlled trial. Participants aged over 18 were recruited and randomized to MZRW or placebo group in addition to current prescriptions (including ongoing laxatives treatment) for two weeks. Exclusion criteria included cognitive impairment, presence of a colostomy or gastrointestinal obstruction and estimated life expectancy of less than one month. Individualized modification of MZRW was allowed according to the traditional Chinese medicine (TCM) pattern of patient. The primary outcome was the global assessment of improvement, which reflected whether the constipation had improved, remained the same or worsened.ResultsSixty patients, with mean age 75.2 years (range 47–95 years), were randomized to MZRW or placebo group. Among the MZRW group, 59.3% (16/27) had improvement in the global assessment score, as compared with 28.6% (8/28) of the placebo group (p-value = 0.022). Besides, the MZRW group had significant increase in stool frequency, and reduction in constipation severity and straining of defecation (p-value < 0.05). No serious adverse event was reported due to the research medication.ConclusionThis pilot trial suggests modified MZRW is well-tolerated and effective for relief of constipation in patients with advance cancer. It could be considered as a potential treatment option for constipation in palliative care.Trial registration: The trial had been registered in ClinicalTrials.gov with identifier number NCT02795390 [https://clinicaltrials.gov/ct2/show/NCT02795390] on June 10, 2016.

01 Jun 2019·Clinical Gastroenterology and HepatologyQ1 · MEDICINE

Efficacy of MaZiRenWan, a Chinese Herbal Medicine, in Patients With Functional Constipation in a Randomized Controlled Trial

Q1 · MEDICINE

Article

Author: Lu, Ai-Ping ; Hu, Dong-Dong ; Xiao, Hai-Tao ; Wu, Justin C Y ; Li, Min ; Zhao, Ling ; Dai, Liang ; Bian, Zhao-Xiang ; Chan, King-Hong ; Ning, Zi-Wan ; Wong, Chi-Tak ; Cheng, Chung-Wah ; Tian, Ke ; Lin, Cheng-Yuan ; Zhong, Linda L D ; Huang, Tao ; Chen, Xiao-Rui ; Lam, Ting-Wa ; Kun, Wai

BACKGROUND & AIMSThe Chinese herbal medicine, MaZiRenWan (MZRW), has been used for more than 2000 years to treat constipation, but it has not been tested in a randomized controlled trial. We performed a trial to evaluate the efficacy and safety of MZRW, compared with the stimulant laxative senna or placebo, for patients with functional constipation (FC).METHODSWe performed a double-blind, double-dummy, trial of 291 patients with FC based on Rome III criteria, seen at 8 clinics in Hong Kong from June 2013 through August 2015. Patients were observed for 2 weeks and then assigned randomly (1:1:1) to groups given MZRW (7.5 g, twice daily), senna (15 mg daily), or placebo for 8 weeks. Patients were then followed for 8 weeks and evaluated at baseline and weeks 4, 8 (end of treatment), and 16 (end of follow up). Participants recorded information on stool form and frequency, feeling of complete evacuation, and research medication taken. Data on individual bowel symptoms, global symptom improvement, and adverse events were collected. A complete response was defined as an increase ≥1 complete spontaneous bowel movement (CSBM)/week from baseline (the primary outcome). Secondary outcomes included response during the follow-up period, colonic transit, individual and global symptom assessments, quality of life measured with 36-item short form Chinese version, and adverse events.RESULTSAlthough there was no statistically significant difference in proportions of patients with a complete response to MZRW (68%) vs. senna (57.7%) (P = .14) at week 8, there was a statistically significant difference vs. placebo (33.0%) (P < .005). At the 16-week timepoint (after the 8-week follow-up period), 47.4% of patients had a complete response to MZRW, 20.6% had a complete response to senna, and 17.5% had a complete response to placebo (P < .005 for MZRW vs. placebo). The group that received MZRW group also had significant increases in colonic transit and reduced severity of constipation, straining, incomplete evacuation, and global constipation symptoms compared with the groups that received placebo or senna in (P < .05 for all comparisons).CONCLUSIONSIn a randomized controlled trial of 291 patients with FC, we found MZRW to be well-tolerated and effective in increasing CSBM/week. MZRW did not appear to be more effective than senna and might be considered as an alternative to this drug. ClincialTrials.gov no: NCT01695850.

01 Dec 2018·Chinese MedicineQ3 · MEDICINE

Approaches in studying the pharmacology of Chinese Medicine formulas: bottom-up, top-down—and meeting in the middle

Q3 · MEDICINE

ReviewOA

Author: Ning, Zi-Wan ; Huang, Tao ; Hu, Dong-Dong ; Bian, Zhao-Xiang ; Zhao, Ling ; Tian, Ke ; Zhang, Man ; Lin, Chen-Yuan ; Zhong, Linda L D ; Cheng, Chung-Wah

Investigating the pharmacology is key to the modernization of Chinese Medicine (CM) formulas. However, identifying which are the active compound(s) of CM formulas, which biological entities they target, and through which signaling pathway(s) they act to modify disease symptoms, are still difficult tasks for researchers, even when equipped with an arsenal of advanced modern technologies. Multiple approaches, including network pharmacology, pharmaco-genomics, -proteomics, and -metabolomics, have been developed to study the pharmacology of CM formulas. They fall into two general categories in terms of how they tackle a problem: bottom-up and top-down. In this article, we compared these two different approaches in several dimensions by using the case of MaZiRenWan (MZRW, also known as Hemp Seed Pill), a CM herbal formula for functional constipation. Multiple hypotheses are easy to be proposed in the bottom-up approach (e.g. network pharmacology); but these hypotheses are usually false positives and hard to be tested. In contrast, it is hard to suggest hypotheses in the top-down approach (e.g. pharmacometabolomics); however, once a hypothesis is proposed, it is much easier to be tested. Merging of these two approaches could results in a powerful approach, which could be the new paradigm for the pharmacological study of CM formulas.

100 Deals associated with MZRW

R&D Status

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Indication	Highest Phase	Country/Location	Organization	Date
Constipation - functional	Phase 1	CN	Hong Kong Baptist University	01 Nov 2014
Gastrointestinal Diseases	Phase 1	CN	Hong Kong Baptist University	01 Nov 2014

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MZRW

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