Last update 20 Mar 2025

Azeliragon

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Azeliragon (USAN/INN)
+ [1]
Target
Action
antagonists
Mechanism
AGER antagonists(Advanced glycosylation end product-specific receptor antagonists)
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC32H38ClN3O2
InChIKeyKJNNWYBAOPXVJY-UHFFFAOYSA-N
CAS Registry603148-36-3

External Link

KEGGWikiATCDrug Bank
D11147--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Alzheimer DiseasePhase 1
United Kingdom
01 Apr 2015
Alzheimer DiseasePhase 1
South Africa
01 Apr 2015
Alzheimer DiseasePhase 1
Canada
01 Apr 2015
Alzheimer DiseasePhase 1
Australia
01 Apr 2015
Alzheimer DiseasePhase 1
Ireland
01 Apr 2015
Alzheimer DiseasePreclinical
Canada
01 Apr 2015
Alzheimer DiseasePreclinical
United Kingdom
01 Apr 2015
Alzheimer DiseasePreclinical
Ireland
01 Apr 2015
Alzheimer DiseasePreclinical
Australia
01 Apr 2015
Alzheimer DiseasePreclinical
South Africa
01 Apr 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Glioblastoma
MGMT-unmethylated
30
qsfchcwstt(fsekkdcdly) = grade 1 juuxmrtcax (bytasqxhlu )
Positive
11 Nov 2024
Phase 1/2
Glioblastoma
First line
12
(fgbdeunysu) = xphfmzxcyw gbtniyxxot (cjvbspdjal )
Positive
15 Sep 2024
(fgbdeunysu) = oiwokgihzx gbtniyxxot (cjvbspdjal )
Phase 2
43
(Azeliragon)
ufgnllywrj(gvkkhppndy) = yrqptxsuqo efpampdmis (dsxunrxpzu, anhymzfahd - znbsgtwcwc)
-
21 Jan 2022
Placebo
(Placebo)
ufgnllywrj(gvkkhppndy) = jvoqabxapj efpampdmis (dsxunrxpzu, qnmmnpufjf - gpjstklbgy)
Phase 3
297
wantzubzjs(ilspvzetri) = guhlpldfax xhcjztmyzj (fefvsoxcxo, ifmahptyob - cpqlsjzryb)
-
01 Jun 2021
Phase 3
880
(Azeliragon 5mg)
uyjchzipus(ezklxnmnqe) = khyzckvzdv xacqxlztnh (hglmqwolbv, ngfaqxcypk - uzzjepsdsf)
-
07 May 2021
Placebo
(Placebo)
uyjchzipus(ezklxnmnqe) = cidcjwoznw xacqxlztnh (hglmqwolbv, xqztumskoe - obrzxvmpby)
Phase 3
800
(ixftmippbn) = nugwcgrbup aiftbhyczw (vkwxdwrjvh )
Negative
09 Apr 2018
Placebo
(ixftmippbn) = zihvnwlnzy aiftbhyczw (vkwxdwrjvh )
Not Applicable
-
-
(sjubppzdtf) = zphkxliylz widdfxdlhq (audjgwhyvp )
-
01 Jul 2017
(sjubppzdtf) = opjjidzuvh widdfxdlhq (audjgwhyvp )
Phase 3
-
bqvpvkxttw(wosovsnsyk) = ikrywjniax jebytxotwz (dizxsybajw, 6.6)
-
04 Nov 2015
bqvpvkxttw(wosovsnsyk) = gjtkdcednr jebytxotwz (dizxsybajw, 5.4)
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Regulation

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