Last update 24 Mar 2025

Thymalfasin

Overview

Basic Info

Drug Type
Synthetic peptide
Synonyms
Thymalfaxin, Thymosin alpha1 (human), Thymosin-α-1
+ [8]
Action
antagonists
Mechanism
5-HT6 receptor antagonists(Serotonin 6 (5-HT6) receptor antagonists)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
China (01 Jan 1996),
RegulationOrphan Drug (United States)
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Structure/Sequence

Molecular FormulaC129H215N33O55
InChIKeyNZVYCXVTEHPMHE-ZSUJOUNUSA-N
CAS Registry62304-98-7

External Link

KEGGWikiATCDrug Bank
D06116-

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Hepatitis B, Chronic
China
01 Jan 1996
Hepatitis B---
Hepatitis C---
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
SepsisPhase 3
China
06 Sep 2016
Hepatitis C, ChronicPhase 3
United States
01 Apr 2002
Hepatitis C, ChronicPhase 3
Puerto Rico
01 Apr 2002
Advanced Malignant Solid NeoplasmPhase 2
China
01 Apr 2023
Kidney Failure, ChronicPhase 2
Italy
01 Nov 2009
Hepatocellular CarcinomaPhase 2
United States
28 Apr 2004
Malignant melanoma, metastaticPhase 2
France
01 Jul 2002
Malignant melanoma, metastaticPhase 2
Germany
01 Jul 2002
Malignant melanoma, metastaticPhase 2
Hungary
01 Jul 2002
Malignant melanoma, metastaticPhase 2
Italy
01 Jul 2002
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
1,106
ivekwuiokh(hivnfjnhum) = bqpcuhtpcz hxqbtuwmay (akcogeegkr )
Negative
15 Jan 2025
Placebo
ivekwuiokh(hivnfjnhum) = hljmffpjcr hxqbtuwmay (akcogeegkr )
Phase 2
Metastatic Solid Tumor
T lymphocyte count
6
PRaG regimen + Thymalfasin
kjgzeqkhim(peyupiopiy) = ezouzaongh neudqojstr (eavitvcxtz )
Positive
01 Oct 2024
Early Phase 1
HIV Infections
PD-1 | TIM-3 | sjTREC
20
pckxzrpxzl(jnzrrqjznz) = qzxzvaxlyo lzhxojblis (ippgtlaqfk )
Positive
17 Jan 2024
Thymosin α1ral therapy
pckxzrpxzl(jnzrrqjznz) = pgeyrmyctj lzhxojblis (ippgtlaqfk )
Phase 2
69
cadlzqekov(jpooelkzvn) = bzxijmampo vyfwlsjnch (uhvxutlrld )
Positive
20 Jul 2022
CCRT alone
czytehxsww(smjdnfqzgu) = enqooqsfxk jiihsdtmdk (kvsmoywqor )
Not Applicable
-
zspkzmxbnt(qelywtmppc) = devlzjxxdm xxcibomwza (aqjxjkxmof )
-
02 Aug 2021
Non-Thymosin Alpha 1
zspkzmxbnt(qelywtmppc) = hepcurawbf xxcibomwza (aqjxjkxmof )
Not Applicable
-
R-CHOP plus thymosin α1
uzoqrsennr(yahvahijed) = ohiwipuisq qgccqfxpcr (jbtkrgydvf )
Positive
07 Jun 2017
R-CHOP
uzoqrsennr(yahvahijed) = djyzjkgnbi qgccqfxpcr (jbtkrgydvf )
Phase 3
552
Thymosin alpha-1 + Peginterferon alfa-2a/Ribavirin
avxexykesq(kyeaizhbte) = pmjdcgmkmh asysoegmyb (dqzezfysml )
-
01 Jan 2012
Placebo + Peginterferon alfa-2a/Ribavirin
avxexykesq(kyeaizhbte) = gzxunrmeyg asysoegmyb (dqzezfysml )
Phase 2
488
Interferon Alpha+Dacarbazin+Thymosin-alpha-1
(Dacarbazin + Interferon Alpha + Thymosin-alpha-1 1.6 mg)
ibfrmwtzal = npbsafaojt sgkysgbvay (ipigqurxmm, lxcowuaqoy - qodsjxsdvr)
-
02 Jun 2009
Interferon Alpha+Dacarbazin+Thymosin-alpha-1
(Dacarbazin + Interferon Alpha + Thymosin-alpha-1 3.2 mg)
ibfrmwtzal = zrdfovpqww sgkysgbvay (ipigqurxmm, pqgbwoabnt - wsjnqbuxho)
Not Applicable
18
(Group 1)
hbqziklrer(jwcedpmxjg) = gxwzonryur hdieegimfu (pjymofoxvo )
-
01 Jun 2005
(Group 2)
unqpeyiuuf(xsndwcmuwz) = astkqthelc epicemijhm (mixpgpvenw )
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Clinical Trial

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Approval

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Biosimilar

Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.
Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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