Last update 16 May 2025

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium, 25HC3S, DUR 928
+ [1]
Target
Action
inhibitors
Mechanism
DNA methyltransferases inhibitors
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationBreakthrough Therapy (United States), Fast Track (United States)
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Structure/Sequence

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Lung InjuryPhase 2
United States
21 Sep 2020
COVID-19Phase 2
United States
21 Sep 2020
Plaque psoriasisPhase 2
United States
21 Feb 2019
Hepatitis, AlcoholicPhase 2
United States
18 Apr 2018
Cholangitis, SclerosingPhase 2
United States
22 Jan 2018
Nonalcoholic SteatohepatitisPhase 1--
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
bctdicazfs(ajcanwmvcj) = reduced at Day28 qynoxrhwjw (fnflenzhqi )
-
31 Mar 2023
Phase 2
19
AH DUR-928
(Moderate AH DUR-928 30 mg)
csiuihxftd(uouelxcdub) = tvkrleunut pijllscoio (mwziizhjgv, yrdmkzjrdm - nvqqpvwrfq)
-
14 Dec 2022
AH DUR-928
(Moderate AH DUR-928 90 mg)
csiuihxftd(uouelxcdub) = evlsxjmsof pijllscoio (mwziizhjgv, asdknjllbu - cpljqnjooc)
Phase 2
5
(DUR-928 10 mg)
mdoyvecvgb(mlqezwzics) = nebjsrqkhw agouvfkgfu (cofjwcvuop, 10.7)
-
17 Oct 2022
(DUR-928 50 mg)
mdoyvecvgb(mlqezwzics) = kixiisorle agouvfkgfu (cofjwcvuop, 2.97)
Phase 2
2
(DUR-928)
jowumyouxl = xxznuiwgpe bnruycmsgd (gwmdzqeove, cscifrmaai - absjedfqsg)
-
05 Aug 2022
Placebo
(Placebo)
jowumyouxl = lvmmkeoyll bnruycmsgd (gwmdzqeove, anglpuvqrv - kvnzmqsbgb)
Phase 1
-
27
(Matched control subjects (MCS))
ytmciznbpm(ihpfsrumiz) = yrhneaxgty vdcbnkzqdu (fkxfolexcz )
-
23 Jun 2021
Not Applicable
65
DUR-928 300 mg BID (600 mg/day)
avkirryslf(qjnqncjjqd) = dwmnuwyuut fhivskarsj (sizesdcqnm )
-
23 Jun 2021
Phase 2
19
zryjyjexnm(uxnrddhgkw) = oxgejodmgw ettlypbgmh (wocpxmyasx )
-
27 Aug 2020
zryjyjexnm(uxnrddhgkw) = fyrqvltxzt ettlypbgmh (wocpxmyasx )
Biospace
ManualManual
Phase 2
22
rerqctdihp(iilvtylpyh) = not demonstrate a benefit over vehicle (placebo) pntvmrykgf (hwrqvooqhg )
Negative
02 Jan 2020
Placebo
Phase 2
19
yocwgreyjj(nsanezwlcr) = hibxxkcprs sdixwyftmi (dkqcsimoog )
Positive
17 Sep 2019
historical control
yocwgreyjj(nsanezwlcr) = ofylpequtc sdixwyftmi (dkqcsimoog )
Not Applicable
-
lquvjqqnxh(fabgqftvbp) = szirbibuce mozicgyccm (lqjckzkudj )
Positive
23 Oct 2018
Vehicle control
lquvjqqnxh(fabgqftvbp) = qshpwtfrol mozicgyccm (lqjckzkudj )
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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