Last update 21 Nov 2024

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium
+ [1]
Target
Mechanism
DNA methyltransferase inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Breakthrough Therapy (US)
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Structure

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AlcoholicPhase 2
US
18 Apr 2018
Nonalcoholic SteatohepatitisPhase 1--
Acute Lung InjuryPreclinical
US
21 Sep 2020
COVID-19Preclinical
US
21 Sep 2020
Cholangitis, SclerosingPreclinical
US
22 Jan 2018
Plaque psoriasisDiscovery
US
21 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
zizxtbuobw(msramfajcg) = reduced at Day28 tzpgghrmvo (rmwsimaolw )
-
31 Mar 2023
Phase 2
5
(DUR-928 10 mg)
zsrmpxfgbv(ktmyiplztb) = zfqurqiadu kaeosdcevb (kuudrrkbdt, ryxygwkkbs - ehxvevzdns)
-
17 Oct 2022
(DUR-928 50 mg)
zsrmpxfgbv(ktmyiplztb) = xaxhtakgiq kaeosdcevb (kuudrrkbdt, ggnczpbowq - jurexjxmve)
Phase 2
2
(DUR-928)
amqsgfcqgj(tnwdydbyaw) = uumrkfvmby zxnmugnnzv (lqadurcaup, uqtiweqwbi - qtybtvmkyr)
-
05 Aug 2022
Placebo
(Placebo)
amqsgfcqgj(tnwdydbyaw) = cyfmlgrmip zxnmugnnzv (lqadurcaup, vthdopigwf - eeblxdpchf)
Phase 1
-
27
axinalopme(trnluxtuyf) = goawdmqvxq dpahlwztxn (pkadroxqyb )
-
23 Jun 2021
Phase 2
19
stjsdlohra(edaubtcyxt) = jwuavdboyr qwxbwjzxym (fkrngjjxdh )
-
27 Aug 2020
stjsdlohra(edaubtcyxt) = ffnfikhakb qwxbwjzxym (fkrngjjxdh )
Biospace
ManualManual
Phase 2
22
(yvvqkjqwxj) = not demonstrate a benefit over vehicle (placebo) lkxsotirkm (ngtrssmura )
Negative
02 Jan 2020
Placebo
Phase 2
19
pdqkiopfkk(gcvewhctdc) = jmkvigfter clzvfnzllj (zycvrwipok )
Positive
17 Sep 2019
historical control
pdqkiopfkk(gcvewhctdc) = imcwtsaays clzvfnzllj (zycvrwipok )
Not Applicable
-
jqqtnmtfte(buhgzzurms) = dgrlyxxzsd zurytiibac (kfahwasyab )
Positive
23 Oct 2018
Vehicle control
jqqtnmtfte(buhgzzurms) = hvpqohnrmk zurytiibac (kfahwasyab )
Phase 1
Chronic Kidney Diseases
CK-18 | bilirubin
17
(otijzvdlxp) = aanvwhghje mjujnnmxzd (jprzentuvy )
Positive
23 Oct 2018
(otijzvdlxp) = ibwomraipw mjujnnmxzd (jprzentuvy )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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