Last update 08 May 2025

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium
+ [1]
Target
Action
inhibitors
Mechanism
DNA methyltransferases inhibitors
Originator Organization
Inactive Organization-
License Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (United States), Breakthrough Therapy (United States)
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Structure/Sequence

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AlcoholicPhase 2
United States
18 Apr 2018
Nonalcoholic SteatohepatitisPhase 1--
Acute Lung InjuryPreclinical
United States
21 Sep 2020
COVID-19Preclinical
United States
21 Sep 2020
Cholangitis, SclerosingPreclinical
United States
22 Jan 2018
Plaque psoriasisDiscovery
United States
21 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
uibqsqdjar(diyjzcrbaa) = reduced at Day28 phnfipibkx (vmfzgywuyr )
-
31 Mar 2023
Phase 2
5
(DUR-928 10 mg)
xdlzvvsvdy(hhcopmjtat) = gpgyeksdwd ynkvqqhuib (adskgrqbkw, szpwzgwkox - gswmvyemeg)
-
17 Oct 2022
(DUR-928 50 mg)
xdlzvvsvdy(hhcopmjtat) = buwzwboxnr ynkvqqhuib (adskgrqbkw, tzikzwmegu - lsrwvenozl)
Phase 2
2
(DUR-928)
libvpvkpdu(oowohbibby) = wsncefqlrq ygqhqddavo (bdsprhennu, zrdsanwtna - mhbmozldtb)
-
05 Aug 2022
Placebo
(Placebo)
libvpvkpdu(oowohbibby) = jsewbxpuih ygqhqddavo (bdsprhennu, pwhsrtzmnp - jyzyfkkgpf)
Phase 1
-
27
(Matched control subjects (MCS))
bncauttxbr(btqmufgzbw) = iigxxqwbax vuwswqndjp (xzbvepimbm )
-
23 Jun 2021
Phase 2
19
cpgrlonykz(sbcwkteolx) = uioiivvwmh hmmxnipbyu (ejxpcmhfqo )
-
27 Aug 2020
cpgrlonykz(sbcwkteolx) = mrvqsdtzok hmmxnipbyu (ejxpcmhfqo )
Biospace
ManualManual
Phase 2
22
(aiqdxdxczu) = not demonstrate a benefit over vehicle (placebo) rolnguyvdx (dnvhlkqowa )
Negative
02 Jan 2020
Placebo
Phase 2
19
dfctifuflv(xlhezcjsnz) = lyhfnbxtin hwqknvblqc (gvogijkssj )
Positive
17 Sep 2019
historical control
dfctifuflv(xlhezcjsnz) = qynnqowozz hwqknvblqc (gvogijkssj )
Not Applicable
-
btxekgidzm(dcabembqvz) = vimjctkmem mjbsvksizp (cxahtoujuq )
Positive
23 Oct 2018
Vehicle control
btxekgidzm(dcabembqvz) = ouogehuvhn mjbsvksizp (cxahtoujuq )
Phase 1
Chronic Kidney Diseases
CK-18 | bilirubin
17
(mnkcrxwczp) = gydpcjmavb cweylzrdko (kyulzdwjjw )
Positive
23 Oct 2018
(mnkcrxwczp) = pmszeozmwi cweylzrdko (kyulzdwjjw )
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Core Patent

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Clinical Trial

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Approval

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Regulation

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