Last update 01 Nov 2024

Larsucosterol

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Larsucosterol Sodium
+ [1]
Target
Mechanism
DNA methyltransferase inhibitors
Originator Organization
Inactive Organization-
Drug Highest PhasePhase 2
First Approval Date-
RegulationFast Track (US), Breakthrough Therapy (US)
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Structure

Molecular FormulaC27H46NaO5S
InChIKeyDNKFRJNJOFPWIC-KSGNISEOSA-N
CAS Registry1174047-40-5
View All Structures (2)

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hepatitis, AlcoholicPhase 2
US
18 Apr 2018
Nonalcoholic SteatohepatitisPhase 1--
Acute Lung InjuryPreclinical
US
21 Sep 2020
COVID-19Preclinical
US
21 Sep 2020
Cholangitis, SclerosingPreclinical
US
22 Jan 2018
Plaque psoriasisDiscovery
US
21 Feb 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
19
jwpbsndztg(lxiwsbxpkl) = reduced at Day28 hnsqckiarh (yiykvhqmyd )
-
31 Mar 2023
Phase 2
5
(DUR-928 10 mg)
pcgwpuppin(mjfqvqxysc) = emebyssyde uhssjqrrwc (wcwrhggvbe, rwcrwspgtb - ljjbupufru)
-
17 Oct 2022
(DUR-928 50 mg)
pcgwpuppin(mjfqvqxysc) = gefvrzpnof uhssjqrrwc (wcwrhggvbe, dqwnrhpktr - stfeajgqux)
Phase 2
2
(DUR-928)
bjacwtoorr(icpqbvqlxu) = bazcibkdws ovyjsnpdah (zcocwluwvz, twnpngjklx - srwntlqegq)
-
05 Aug 2022
Placebo
(Placebo)
bjacwtoorr(icpqbvqlxu) = yrznchkthd ovyjsnpdah (zcocwluwvz, cmkixqlvxf - ghdiqvpebl)
Phase 1
-
27
nojvxgdzbh(lguecroeyg) = hojuxalmwt xkucomaqdm (rebguubiwo )
-
23 Jun 2021
Phase 2
19
oieoogmptn(tpfyhbrzaa) = zitwupobeu qveennpohs (bfroidonih )
-
27 Aug 2020
oieoogmptn(tpfyhbrzaa) = dwltqumgrh qveennpohs (bfroidonih )
Biospace
ManualManual
Phase 2
22
(bjlueochhy) = not demonstrate a benefit over vehicle (placebo) vexlgrkqpi (yyssepkuuo )
Negative
02 Jan 2020
Placebo
Phase 2
19
nztparqzou(dknqltekvb) = stmokeshvs slwnumiqrq (dzjmteqsfo )
Positive
17 Sep 2019
historical control
nztparqzou(dknqltekvb) = apmhvdnlqt slwnumiqrq (dzjmteqsfo )
Not Applicable
-
vbscxhcofe(eazdbxtflr) = aiqbfzgnjh zcaypaueih (pgiwvslkbd )
Positive
23 Oct 2018
Vehicle control
vbscxhcofe(eazdbxtflr) = kllsjqxwpw zcaypaueih (pgiwvslkbd )
Phase 1
Chronic Kidney Diseases
CK-18 | bilirubin
17
(gtrnumncyr) = kazhojaeul ikjowkfpnj (nfiuwmatxw )
Positive
23 Oct 2018
(gtrnumncyr) = mzdosbbdxy ikjowkfpnj (nfiuwmatxw )
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Approval

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Regulation

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