Last update 01 Nov 2024

Squalamine lactate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
EVIZON, Squalamine lactate (USAN), Squalamine lactate hydrate
+ [4]
Mechanism
PDGF inhibitors(Platelet-derived growth factor inhibitors), VEGF-C inhibitors(Vascular endothelial growth factor C inhibitors), Angiogenesis inhibitors
Active Indication-
Originator Organization
Active Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
RegulationOrphan Drug (US)
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Structure

Molecular FormulaC37H71N3O8S
InChIKeyJMNXSNUXDHHTKQ-QVMSTPCGSA-N
CAS Registry320725-47-1

External Link

KEGGWikiATCDrug Bank
D05914Squalamine lactate-

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Choroidal NeovascularizationPhase 3
US
01 Jun 2005
Choroidal NeovascularizationPhase 3
US
01 Jun 2005
Wet age-related macular degenerationPhase 3
US
01 Jun 2005
Wet age-related macular degenerationPhase 3
US
01 Jun 2005
Non-Small Cell Lung CancerPhase 3
US
-
Ovarian CancerPhase 3
US
-
Prostatic CancerPhase 3
US
-
Retinal Vein OcclusionPhase 3
US
-
Retinal Vein OcclusionPhase 3
US
-
Wet Macular DegenerationPhase 3
CA
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
237
Ranibizumab+squalamine
(svqgwbuzkf) = wxymznitwg qslnxlcblv (cqpypqtxmb )
Negative
05 Jan 2018
Ranibizumab+Placebo
(svqgwbuzkf) = jdycsuprfw qslnxlcblv (cqpypqtxmb )
Phase 2
-
(qdfubvcscx) = There were no serious adverse events related to study drug reported. A small number of patients reported injection site pain, but no patients withdrew due to adverse events lycpachglg (yurtsosmpq )
-
01 May 2005
Phase 2
45
(hersbjfrcm) = yorcycbwla vaupsndkbc (uwtbrsemdl )
Negative
15 Jul 2004
(hersbjfrcm) = tcmtljujjp vaupsndkbc (uwtbrsemdl )
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Regulation

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