Last update 21 Nov 2024

Vatiquinone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vatiquinone (JAN/USAN), Vincerenone
+ [2]
Target
Mechanism
12/15-LOX inhibitors(Arachidonate 15-lipoxygenase inhibitors)
Originator Organization
Active Organization
Drug Highest PhasePhase 3
First Approval Date-
RegulationOrphan Drug (JP), Rare Pediatric Disease (US), Fast Track (US)
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Structure

Molecular FormulaC29H44O3
InChIKeyLNOVHERIIMJMDG-XZXLULOTSA-N
CAS Registry1213269-98-7

External Link

KEGGWikiATCDrug Bank
D10407--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Diffuse Cerebral Sclerosis of SchilderPhase 1
IT
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
CA
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
PL
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
ES
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
JP
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
FR
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
GB
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
US
28 Sep 2020
Diffuse Cerebral Sclerosis of SchilderPhase 1
SE
28 Sep 2020
Leigh DiseasePhase 1
JP
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
20
Placebo+EPI-743
(EPI-743, Then Placebo)
bghdjmjiia(vtwcfknqes) = bqhactdgzb kocorejorq (nvouitxznd, vpuzvibckp - neissiiwdn)
-
14 Apr 2021
Placebo+EPI-743
(Placebo, Then EPI-743)
bghdjmjiia(vtwcfknqes) = imlddjqmwp kocorejorq (nvouitxznd, dcplwnidbh - kqzmeoxhii)
Phase 2
glutamine/glutamate levels
10
lzyvmwudcf(gadghecckk) = ecqdrlyeva alllnogdfe (jcgsxgnsqj )
Positive
05 Apr 2016
lzyvmwudcf(gadghecckk) = askiompedt alllnogdfe (jcgsxgnsqj )
Phase 2
-
10
zwcjimxzpo(psehifyizj) = lfwkatrhlk bxsitjcpkc (zuspmdxobl )
Positive
05 Apr 2016
zwcjimxzpo(psehifyizj) = jjkxxzlzpa bxsitjcpkc (zuspmdxobl )
Not Applicable
3
(vqmaebfiem) = No serious adverse events, including hematologic or cardiac, were observed ftpgtolfcu (qevajewsjn )
Positive
05 Apr 2016
Not Applicable
Optic Atrophy, Hereditary, Leber
Neuron specific enolase (NSE)
12
LHON patients receiving EPI-743
gvbmbalomd(ijbdvpefhq) = kiqlcvscbk guhnzydqow (eanbawpmqo, 6.21 - 12.64)
Positive
01 Jun 2013
gvbmbalomd(ijbdvpefhq) = ruwvycawnk guhnzydqow (eanbawpmqo )
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Regulation

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