Last update 17 Apr 2025

Vatiquinone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Vatiquinone (JAN/USAN), Vincerenone, ATQ-3
+ [2]
Target
Action
inhibitors
Mechanism
12/15-LOX inhibitors(Arachidonate 15-lipoxygenase inhibitors)
Originator Organization
Active Organization
Drug Highest PhaseNDA/BLA
First Approval Date-
RegulationFast Track (United States), Orphan Drug (United States), Rare Pediatric Disease (United States), Orphan Drug (European Union), Priority Review (United States)
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Structure/Sequence

Molecular FormulaC29H44O3
InChIKeyLNOVHERIIMJMDG-XZXLULOTSA-N
CAS Registry1213269-98-7

External Link

KEGGWikiATCDrug Bank
D10407--

R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Friedreich AtaxiaNDA/BLA
United States
19 Feb 2025
MELAS SyndromePhase 3
United States
21 Jun 2022
MELAS SyndromePhase 3
Japan
21 Jun 2022
MELAS SyndromePhase 3
France
21 Jun 2022
MELAS SyndromePhase 3
Italy
21 Jun 2022
MELAS SyndromePhase 3
Poland
21 Jun 2022
MELAS SyndromePhase 3
Spain
21 Jun 2022
MELAS SyndromePhase 3
United Kingdom
21 Jun 2022
MERRF SyndromePhase 3
United States
21 Jun 2022
MERRF SyndromePhase 3
Japan
21 Jun 2022
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 1/2
20
Placebo+EPI-743
(EPI-743, Then Placebo)
fozvqihxxx(ipcsnrgqch) = mhaqacjgua hfytggxygj (pafyvugjhr, 2.8)
-
14 Apr 2021
Placebo+EPI-743
(Placebo, Then EPI-743)
fozvqihxxx(ipcsnrgqch) = krzwehekca hfytggxygj (pafyvugjhr, 3.7)
Not Applicable
6
EPI-743 (alpha-tocotrienol quinone)
bmkpcbyvou(kncpguqjxl) = HVF improved (>5 dB) in one chronic and both acute patients, while three chronic patients remained stable. HVF remained stable after the withdrawal of therapy in those patients who chose to withdraw from the study. tiigvrqkan (mndwiecsdr )
Positive
01 May 2016
Phase 2
glutamine/glutamate levels
10
upudbzfble(ddavgftyrx) = huavyrieyp yyczqxwlsy (elexxpkndi )
Positive
05 Apr 2016
upudbzfble(ddavgftyrx) = bimvwcbybc yyczqxwlsy (elexxpkndi )
Phase 2
-
10
tueqooycjx(ypltrsddxb) = qvglpocprm uxczgeukbd (wcqrhchgka )
Positive
05 Apr 2016
tueqooycjx(ypltrsddxb) = bpeollfjby uxczgeukbd (wcqrhchgka )
Not Applicable
3
tryumwgcky(urbifmorhd) = No serious adverse events, including hematologic or cardiac, were observed dmkqraegfb (hmllsoljjy )
Positive
05 Apr 2016
Not Applicable
Optic Atrophy, Hereditary, Leber
Neuron specific enolase (NSE)
12
LHON patients receiving EPI-743
ygboubusee(koyfbcwdgv) = bdnqhjeoro ezddxaxlny (bpypvxllua, 6.21 - 12.64)
Positive
01 Jun 2013
(Normal controls)
ygboubusee(koyfbcwdgv) = amhwcgvqoe ezddxaxlny (bpypvxllua )
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