This study is a prospective, randomized, parallel, phase 1 trial to assess the safety and feasibility of the transplantation of bone marrow derived mesenchymal stem cells (MSCs) in fistulizing Crohn's disease.

Start Date01 Feb 2013

Sponsor / Collaborator

Royan Institute

NCT01115634 / CompletedPhase 2IIT

Autologous Transplantation of Cultured Fibroblast for Facial Contour Deformities

Beautiful skin requires maintenance of proper care. Skin exercise, protections from direct sunlight or harsh wind, and maintaining a healthy diet are some of the ways of having a good and radiant skin. However despite all the care taken passage of time will bring about conditions that will automatically lead to skin aging, which may require certain therapeutic, care. Fibroblasts are cells that synthesize the extracellular matrix and collagen and play a critical role in wound healing and maintenance of healthy skin. Loosing of fibroblast cell is the main problem in aging and wrinkles and non-healed skin wounds. Therefore proliferation of skin fibroblast along with differentiation of stem cells in the skin tissue is the best method for healing.

Start Date01 Sep 2008

Sponsor / Collaborator

Royan Institute

100 Clinical Results associated with Fibroblast(Royan Institute)

100 Translational Medicine associated with Fibroblast(Royan Institute)

100 Patents (Medical) associated with Fibroblast(Royan Institute)

Literatures (Medical) associated with Fibroblast(Royan Institute)

01 Jun 2024·Academic Radiology

68Ga-DOTA.SA.FAPi as a Versatile Diagnostic Probe for Various Epithelial Malignancies: A Head-to-Head Comparison with 18F-FDG

Article

Author: Singh, Harmandeep ; Walia, Rama ; Roesch, Frank ; Kumar, Rajender ; Shukla, Jaya ; Irrinki, Santhosh ; Mathur, Yamini ; Duseja, Ajay ; Chopra, Sejal ; Rana, Nivedita ; Moon, Euy Sung ; Mittal, Bhagwant Rai

RATIONALE AND OBJECTIVESFibroblast Activation Protein (FAP) expressing cancer-associated fibroblasts has been a major breakthrough causing a paradigm shift in targeted theranostics focusing on the tumor microenvironment. In this study, a squaric acid derivative DOTA.SA.FAPi (SA.FAPi) has been evaluated as a potential diagnostic probe in diverse epithelial cancers and compared to the standard-of-care ¹⁸F-FDG.METHODS25 patients enrolled in this prospective study underwent ¹⁸F-FDG and ⁶⁸Ga-SA.FAPi PET scans on two different days. For biodistribution, standardized uptake values (SUV) were computed by delineating region-of-interest on various body organs. For comparative analysis in disease identification, lesion tracer uptake was quantified using SUVs corrected for lean body mass (SUL), SUV_max, tumor-to-background ratio (TBR) with liver and blood pool as the reference, total lesion glycolysis (TLG for ¹⁸F-FDG) and total lesion FAP expression (TLF for ⁶⁸Ga-SA.FAPi).RESULTS25 patients (mean age: 58 ± 8 years) with four types of cancers including hepatocellular carcinoma (HCC, 56% of cohort), gall bladder carcinoma (GB Ca, 12%), adrenocortical carcinoma (ACC, 16%), and breast carcinoma (breast Ca, 16%) were prospectively evaluated. Physiological tracer uptake of ⁶⁸Ga-SA.FAPi was noted in the salivary glands, thyroid, liver, pancreas, muscles and kidneys with variable uptake in the lacrimal glands, extra-ocular muscles, oral mucosa and uterus. Lesion-based comparative analysis between both the radiotracers demonstrated complete concordant findings in detection of all primary lesions and distant metastases in liver, bones, adrenals and peritoneum whereas discordant findings were noted in lung nodules (20%) and lymph nodes (13%). In overall analysis, ⁶⁸Ga-SA.FAPi exhibited significantly higher SUV_max (10.3 vs 8.8, p-0.019), SUL_peak (6.8 vs 4.9, p-0.000) and SUL_avg (5.4 vs 4.1, p-0.019) in comparison to ¹⁸F-FDG whereas TBR was comparable for both the tracers [TBR_Liver: median 1.9 (IQR: 2.6-1.4) vs 1.8 (2.6-1.1), p-0.275; TBR_Bloodpool: 2.1 (3.7-1.4) vs 2.0 (2.7-1.4), p-0.207]. In subcategorical analysis, ⁶⁸Ga-SA.FAPi demonstrated higher SUV_max, SUL_peak and SUL_avg values for primary disease (SUV_max: 14.8 (18.7-9.7) vs (12.9-6.6), p-0.087; SUL_peak: 8.2 (11.2-6.8) vs 6.3 (8.5-4.4), p-0.037; SUL_avg: 6.9 ± 2.5 vs 5.1 ± 2.2, p-0.023] and distant metastases (8.8 vs 7.2, p-0.038); 6.3 (8.8-4.4) vs 3.6 (4.4-2.0), p-0.000; 5.4 vs 3.5, p-0.000] whereas comparable values were noted for both the tracers in nodal metastases [9 (13.5-4.1) vs 8 (12.7-4.7), p-0.726; 4.5 (6.2-1.8) vs 4.3 (5.7-2.2), p-0.727; 4.1 ± 2.3 vs 3.7 ± 1.8, p-0.129]. In primary disease, highest ⁶⁸Ga-SA.FAPi avidity was noted in ACC followed by GB Ca and HCC. In distant metastases, gall bladder, lung and skeletal lesions demonstrated higher ⁶⁸Ga-SA.FAPi avidity. Moreover, ⁶⁸Ga-SA.FAPi identified five additional lung lesions which were missed by ¹⁸F-FDG in one case of ACC.CONCLUSION⁶⁸Ga-SA.FAPi emerged as an effective, versatile diagnostic probe for imaging various epithelial malignancies similar to ¹⁸F-FDG.

12 Dec 2023·Cureus

Fibroblast Viability Through Mechanical and Chemical Root Surface Modifications in Periodontal Healing: An In Vitro Comparative Study

Article

Author: Felemban, Baher

BACKGROUNDThe wound-healing process incorporates a spectrum of periodontal therapeutic interventions that strive to restore the health and function of the periodontium. Fibroblasts play pivotal roles in tissue repair and regeneration. Extensive research has been focused on mechanical and chemical root surface modifications to enhance fibroblast adhesion, which is crucial for successful wound healing.PURPOSEThis study aimed to assess the combined efficacy of mechanical and chemical root surface modifications in promoting fibroblast viability to root surfaces affected by periodontitis in comparison to chemical modifications alone.MATERIALS AND METHODSRoot samples were collected from healthy individuals and those with advanced periodontitis. The specimens were prepared, and the experimental groups were categorized based on the type of surface modification with mechanical and/or chemical materials, including hyaluronic acid (HA), ethylenediaminetetraacetic acid (EDTA), enamel matrix derivatives (EMD), and EDTA/EMD. Fibroblasts were seeded onto previously treated root samples. Cell adhesion was assessed using a viability assay.RESULTSFibroblast viability was significantly higher on root surfaces treated with chemical agents than on those treated with mechanical and chemical modifications. Long-duration EDTA and short-duration EMD treatments were significantly effective in enhancing cell viability. EDTA/EMD surface treatments resulted in significantly higher cell viability in all groups compared to the periodontitis root surfaces.CONCLUSIONEDTA, EMD, and their combined application can potentially ameliorate periodontitis-induced surface structural impairments. Mechanical surface debridement can significantly affect the effectiveness of EDTA and EMD root conditioning agents.

01 Sep 2011·Molecular ImmunologyQ3 · MEDICINE

A novel mutation in the C3 gene and recurrent invasive pneumococcal infection: A clue for vaccine development

Q3 · MEDICINE

Article

Author: Véronique Fremeaux-Bacchi ; Zvi Fishelson ; Penina Koch ; Michael Goldberg ; Yitzhak Katz

BACKGROUNDWe identified a 4 year-old boy born to a consanguineous marriage with C3 deficiency after three episodes of invasive pneumococcal disease. The efficacy of anti-pneumococcal vaccination in C3 deficient patients is not clear.OBJECTIVESOur objective was to identify the genetic defect resulting in his C3 deficiency and measure his ability to mount an adaptive immune response.METHODSFibroblast cell lines were generated from the patient and parents. DNA was isolated and the C3 gene sequenced. Quantitation of C3 expression was performed by immunoprecipitation of (35)S-methionine labeled protein. Isotype specific anti-pneumococcal antibodies present in the patients sera was quantitated after administration of Prevnar-7 and Pneumovax vaccines.RESULTSPneumococcal types 14, 10B and 29 were identified from the blood on three separate occasions over a period of 20 months. C3 levels in the blood was <10, 71, and 66 for the patient, mother and father, respectively (90-180mg/dl, normal). Sequencing revealed a homozygous deletion of one nucleotide located in exon 31 (delA in position 3997 of cDNA) which resulted in a transcriptional stop signal thirteen codons later. The parents were heterozygous for the mutation. No detectable C3 was noted by immunoprecipitation. The patient mounted adequate antibody responses to the protein-conjugated Prevnar and tetanus vaccines but not to the polysaccharide antigen based Pneumovax vaccine. Major immunoglobulin class levels were normal.CONCLUSIONC3 deficiency results in the selective impairment to mount a response against polysaccharide-based antigens. Protein-conjugated vaccines are likely to be efficacious in immunizing against encapsulated organisms in these patients.

100 Deals associated with Fibroblast(Royan Institute)

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Indication	Highest Phase	Country/Location	Organization	Date
Acne Scar	Phase 2	IR	Royan Institute	01 Sep 2008
Congenital Abnormalities	Phase 2	IR	Royan Institute	01 Sep 2008
Forehead lines	Phase 2	IR	Royan Institute	01 Sep 2008
Glabellar frown lines	Phase 2	IR	Royan Institute	01 Sep 2008
Nasolabial fold wrinkles	Phase 2	IR	Royan Institute	01 Sep 2008

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