10 adult patients who have undergone nasal reconstructive surgery and had skin from their forehead used to cover this wound will be asked to participate. Treatment will be of the scar on their forehead, using a silicone ointment, on half of the scar, and CBD oil + silicone ointment, on the second half. Pictures will be taken during the treatment of the scar and questionnaires will be completed. Also, doctors will look at the pictures taken during the healing process and grade the healing of the scar areas.

Start Date01 Sep 2024

Sponsor / Collaborator

University of Oklahoma

NCT05894109 / WithdrawnNot ApplicableIIT

Efficacy of Zinc Supplementation on Botox Treated Forehead Rhytids

The current literature suggests that zinc supplementation may increase the duration of botulinum toxin; however, each study had their limitations. Further, no one has studied the effect of zinc supplementation for botulinum toxin treatment of the forehead. The purpose of this study is to evaluate the effect of zinc supplementation on frontalis muscle denervation by objectively assessing the degree of forehead rhytids and movement of the eyebrows.

Start Date01 Aug 2024

Sponsor / Collaborator

The University of New Mexico

[+1]

CTIS2024-511047-26-01 / Not yet recruitingIIT

DIFFUSION CHARACTERISTICS OF LETIBOTULINUMTOXIN A IN COMPARISON TO ONA AND ABO-BONTA - 20231129

Start Date07 Jun 2024

Sponsor / Collaborator

Hamburg University of Applied Sciences

[+1]

100 Clinical Results associated with Forehead lines

100 Translational Medicine associated with Forehead lines

0 Patents (Medical) associated with Forehead lines

128

Literatures (Medical) associated with Forehead lines

01 Jul 2024·Aesthetic Plastic Surgery

Clinical Outcomes of Utilizing a "W"-shaped Incision in the Management of Forehead Skin Thickening Induced by Hypertrophic Osteoarthropathy

Article

Author: Guan, Yuanyuan ; Deng, Huiling ; Wang, Jiecong ; Dong, Quping

BACKGROUNDHypertrophic osteoarthropathy (HOA) is a rare and intricate hereditary disease. The appearance and functional deformity of the forehead caused by thickened folds are the main clinical manifestations of patients with hypertrophic osteoarthropathy. The cause of this disease is still unknown. Currently, surgical treatment has become one of the best strategies, mainly for improving the appearance of the forehead. There has been no literature report on the use of "W"-shaped skin flap resection for thickened forehead skin in patients with hypertrophic osteoarthropathy.METHODSAll cases of hypertrophic osteoarthropathy in our department in the last 7 years, and previous literature on hypertrophic osteoarthropathy, were reviewed.RESULTSA total of 5 cases of hypertrophic osteoarthropathy in our department (mean age 21 years, all male patients) were reviewed. All patients underwent open surgery to remove the thickened skin on the forehead or the wrinkles and gyrus-shaped scalp. The jagged skin tissue was removed (8-9) cm × (1-2.5) cm × 0.5 cm. The folds and thickness of the frontal skin of the patients were greatly improved after the operation. Patient satisfaction with the treatment outcomes was unanimous. However, one case experienced a postoperative wound infection during follow-up. The utilization of the "W"-shaped excision technique allowed for the maximal removal of excessively diseased tissue, thereby facilitating a smoother resolution of the depression.CONCLUSIONSA total of 5 cases of hypertrophic osteoarthropathy were treated in our department, and all of them underwent frontal skin "W"-shaped excision, which was safe, feasible, and practical, and the postoperative results were satisfactory.LEVEL OF EVIDENCE IVThis journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

01 Jun 2024·Journal of Maxillofacial and Oral Surgery

Comparison of Wrinkle Patterns Generated by Intradermal and Intramuscular Botulinum Toxin Injections by Clinical Evaluation

Article

Author: Mitra, Rituparna ; Panneerselvam, Elavenil ; Raja, V B Krishna Kumar

PurposeBotulinum toxin has played a remarkable role in management of forehead wrinkles. Most used is intramuscular technique due to its deposition into the muscles, however, with adverse effects like brow ptosis. This study has been designed for the evaluation of efficacy for intradermal v/s intramuscular route of botulinum toxin injections for forehead wrinkles using clinical correlation.MethodsThis study included a clinical trial of 32 facial halves divided equally into intradermal and intramuscular injection technique groups, receiving total dose of 8 U. Results were assessed by clinical examination upto 2 weeks and 4 weeks with parameters; objective wrinkle rate, eyebrow height, eyebrow movement, pain, and satisfaction after treatment.ResultResults showed least mean for objective wrinkle rate in intramuscular group, showing statistically significant improvement. Overall improvement in eyebrow height and eyebrow movement were slightly more for intramuscular group. Pain was lesser for intradermal group, whereas satisfaction of patient of patient post treatment is similar for both the groups.ConclusionAmong intradermal and intramuscular botulinum toxin injection technique, the effect and potency were better for intramuscular technique, whereas the patient comfort and compliance were better for intradermal technique.

01 Apr 2024·Skin Research and Technology

The efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines in Asians – A clinical, prospective, interventional, split‐face study

Article

Author: Kim, Soo-Bin ; Wan, Jovian ; Sy, Jessica Jane ; Wu, Raymond ; Yi, Kyu-Ho

AbstractBackground:Botulinum toxin injections are widely sought after in the field of medical aesthetics, offering consumers a variety of brand choices. Two commonly available botulinum toxin products, onabotulinumtoxinA and neubotulinumtoxinA, are featured in numerous clinics, leading many to question whether there are discernible differences in results, given their varying price ranges.ObjectiveTo evaluate the efficacy and safety of neubotulinumtoxinA for the treatment of forehead horizontal lines.MethodsA 12‐week prospective, single‐centre, interventional split‐face study was conducted, including 30 subjects. These enrolled subjects received a single treatment session, with neubotulinumtoxinA applied to the left side of the forehead and onabotulinumtoxinA to the right side. A superficial injection was performed in all individuals, where the product was injected subdermally in the frontalis muscle. Evaluation was conducted at baseline, 7 days, 14, days and 4, 8, and 12 weeks after treatment, both when the eyebrows were at maximum lift and in a resting position. Treatment efficacy was assessed by two physicians and self‐assessed by the patients, using the Fitzpatrick Wrinkle Classification system. Adverse events were documented to evaluate safety.ResultsThe study found no statistically significant difference in the efficacy of neubotulinum and onabotulinum for treating forehead wrinkles, as indicated by p‐values above 0.05 for both static and dynamic conditions. No safety and adverse events were observed in both formulations.ConclusionThis study has demonstrated that neither formulation is inferior to each other in the treatment of forehead horizontal lines.

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